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Protein Overview: VhaAC39-PA

General Information:
Name(s) found: VhaAC39-PA / FBpp0070584 [FlyBase]
Description(s) found:
Found 24 descriptions.
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  • The gene Vacuolar H<sup>+</sup>-ATPase C39 subunit is referred to in FlyBase by the symbol Dmel\VhaAC39 (CG2934, FBgn0028665). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:3774773..3777004. It has the cytological map location 3F4. Based on sequence similarity, it is predicted to have molecular function</span>: hydrogen-exporting ATPase activity, phosphorylative mechanism. There is experimental evidence that it is involved in the biological process</span>: regulation of Notch signaling pathway; vacuolar acidification. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 350 amino acids

    Gene Ontology:
    Cellular Component: vacuolar proton-transporting V-type ATPase, V0 domain [ISS][NAS]
    Biological Process: proton transport [NAS]
    regulation of Notch signaling pathway [IMP]
    vacuolar acidification [IMP]
    ATP synthesis coupled proton transport [IEA]
    Molecular Function: hydrogen-exporting ATPase activity, phosphorylative mechanism [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNSSGFMFNI DNGYLEGLCR GFKCGILKQA DYLNLVQCET LEDLKLHLQG TDYGSFLANE  60
   61 PSPLSVSVID DKLREKLVIE FQHMRNHAVE PLSNFLDFIT YGYMIDNIIL LITGTLHQRP 120
  121 ISELIPKCHP LGSFEQMEAI HVASTPAELY NAVLVDTPLA PFFVDCISEQ DLDEMNIEII 180
  181 RNTLYKAYLE AFYNFCKNMG GATADVMCEI LAFEADRRAI IITINSFGTE LSKDDRAKLY 240
  241 PNCGKMYPDG LAALARADDY EQVKTVAEYY AEYAALFDGS GNNPGDKTLE DKFFEHEVKL 300
  301 DVYAFLQQFH FGVFYAYLKL KEQECRNIVW IAECVAQKHR AKIDNYIPIF

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..350] PSI-BLAST 48.69897 Crystal Structure of Subunit C of V-ATPase


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.91

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle