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Protein Overview: gt-PB

General Information:
Name(s) found: gt-PB / FBpp0070444 [FlyBase]
Description(s) found:
Found 25 descriptions.
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  • The gene giant is referred to in FlyBase by the symbol Dmel\gt (CG7952, FBgn0001150). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:2321140..2322996. It has the cytological map location 3A3. Based on sequence similarity, it is predicted to have molecular function</span>: specific RNA polymerase II transcription factor activity; protein homodimerization activity; protein heterodimerization activity. There is experimental evidence that it is involved in the biological process</span>: torso signaling pathway; terminal region determination; ring gland development; phagocytosis, engulfment. 84 alleles are reported. The phenotypes of these alleles are annotated with 30 unique terms, many of which group under: organ system; abdominal segment 7; abdominal ventral denticle belt; embryonic segment; embryonic abdomen; peripheral nervous system; larval abdominal segment; thoracic segment; cephalopharyngeal skeleton; external compound sense organ. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 448 amino acids

    Gene Ontology:
    Cellular Component: nucleus [ISS][NAS]
    Biological Process: negative regulation of transcription from RNA polymerase II promoter [NAS][TAS]
    torso signaling pathway [IGI]
    specification of segmental identity, labial segment [IMP]
    negative regulation of multicellular organism growth [IMP]
    posterior head segmentation [TAS]
    phagocytosis, engulfment [IMP]
    terminal region determination [IGI]
    ring gland development [IMP]
    regulation of transcription, DNA-dependent [IEA]
    salivary gland development [TAS]
    zygotic determination of anterior/posterior axis, embryo [NAS][TAS]
    Molecular Function: DNA binding [NAS]
    transcription factor activity [IEA]
    protein homodimerization activity [ISS]
    protein heterodimerization activity [ISS]
    specific RNA polymerase II transcription factor activity [ISS]
    protein dimerization activity [IEA]
    sequence-specific DNA binding [IEA]
    specific transcriptional repressor activity [NAS][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLMHEKLMAG QFFDLKTDRK PLMHHHQYQH HQQQPLHHLP HSQLPVQGSL GLPKMDLYTA  60
   61 YAYQQQLLGA ALSQQQQQQQ QQQQHQQLQQ QHTSSAEVLD LSRRCDSVET PRKTPSPYQT 120
  121 SYSYGSGSPS ASPTSNLLYA AQMQQQQHQQ QQQQQQQQQQ LASLYPAFYY SNIKQEQATP 180
  181 TAAPPKVTPT ANLLQTFAAA SAAAAAAAAA SSTNSPRPAS NASTMQIDVL ENPLSPAVEA 240
  241 TTPTTSSSGE AGKNTRPFKA FPRDPLVIAA NFAATDVLLD NPRVERYTEY RKRVLEQIRS 300
  301 SNGGSRTVTN PKMRRTNSRS GSVNEGSSSN NNSESEDRAA AEESSDCDSQ AGNFESKSAT 360
  361 SSSSNLANAT AANSGISSGS QVKDAAYYER RRKNNAAAKK SRDRRRIKED EIAIRAAYLE 420
  421 RQNIELLCQI DALKVQLAAF TSAKVTTA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..131] FFAS03 0.971 No description for 2q2fA was found.
    2 View Details [132..320] MSA 4.213985 View MSA. No confident structure predictions are available.
    3 View Details [321..379] deduced N/A No confident structure predictions are available.
    4 View Details [380..448] PSI-BLAST 20.0 Structure Of The DNA Binding Domains Of IRF3, ATF-2 and Jun Bound To DNA


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.84

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle