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Protein Overview: FBpp0305706

General Information:
Name(s) found: FBpp0305706 [FlyBase]
Description(s) found:
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  • gi|7290318|gb|AAF45778.1| CG14045 [Drosophila melanogaster] [NCBI NR]
  • gi|20128933|ref|NP_570002.1| CG14045 [Drosophila melanogaster] [NCBI NR]
  • type=protein; loc=X:complement(2272163..2273249,2273311..2273488,2273547..2274426,2274792..2275977,2277529..2277636,2278272..2278548,2278886..2279759); ID=FBpp0305706; name=PsGEF-PA; parent=FBgn0264598,FBtr0333526; dbxref=REFSEQ:NP_570002,GB_protein:AAF45778,FlyBase_Annotation_IDs:CG43947-PA,FlyBase:FBpp0305706; MD5=b1976cd22c8bd2d3cef8517a5c96da6a; length=1529; release=r5.56; species=Dmel; [FlyBase]
  • The gene Protostome-specific GEF is referred to in FlyBase by the symbol Dmel\PsGEF (CG14045, FBgn0040387). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:2272151..2281697. It has the cytological map location 3A2. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: Rho guanyl-nucleotide exchange factor activity; protein binding. There is experimental evidence that it is involved in the biological process</span>: mushroom body development. 6 alleles are reported. The phenotype of these alleles is annotated with: mushroom body alpha-lobe. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • >CG14045-PA translation from_gene[CG14045 EG:BACH7M4.1 FBgn0040387] seq_release:3 mol_weight=165990 cds_boundaries:(X:2,134,905..2,142,498[-]) aa_length:1529 transcript_info:[CG14045-RA seq_release:3] gene_info:[gene symbol:EG:BACH7M4.1 FBgn0040387 gen [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9W4Y9) EG:BACH7M4.1 protein (CG14045 protein) [DrosMelano7227.FASTAC.txt]
  • (AE003424) EG:BACH7M4.1 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG14045-PA [Drosophila melanogaster]gi|20128933|ref|NP_570002.1| CG14045-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=X:complement(2272163..2273249,2273311..2273488,2273547..2274426,2274792..2275977,2277529..2277636,2278272..2278548,2278886..2279759); ID=FBpp0070447; name=CG14045-PA; parent=FBgn0040387,FBtr0070463; dbxref=FlyBase:FBpp0070447,FlyBase_Ann [fly-100309-contam.fasta]
  • CG14045-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=X:complement(2272163..2273249,2273311..2273488,2273547..2274426,2274792..2275977,2277529..2277636,2278272..2278548,2278886..2279759); ID=FBpp0070447; name=CG14045-PA; parent=FBgn0040387,FBtr0070463; dbxref=FlyBase:FBpp0070447,FlyBase_Annotation_IDs:CG14045-PA,GB_protein:AAF45778.1,REFSEQ:NP_570002,GB_protein:AAF45778; MD5=b1976cd22c8bd2d3cef8517a5c96da6a; length=1529; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=X:complement(2272163..2273249,2273311..2273488,2273547..2274426,2274792..2275977,2277529..2277636,2278272..2278548,2278886..2279759); ID=FBpp0070447; name=PsGEF-PA; parent=FBgn0040387,FBtr0070463; dbxref=FlyBase:FBpp0070447,FlyBase_Annotation_IDs:CG14045-PA,GB_protein:AAF45778.1,REFSEQ:NP_570002,GB_protein:AAF45778; MD5=b1976cd22c8bd2d3cef8517a5c96da6a; length=1529; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Protostome-specific GEF, isoform A OS=Drosophila melanogaster GN=PsGEF PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=X:complement(2272163..2273249,2273311..2273488,2273547..2274426,2274792..2275977,2277529..2277636,2278272..2278548,2278886..2279759); ID=FBpp0305706; name=PsGEF-PA; parent=FBgn0264598,FBtr0333526; dbxref=FlyBase_Annotation_IDs:CG43947-PA,FlyBase:FBpp0305706; MD5=b1976cd22c8bd2d3cef8517a5c96da6a; length=1529; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=X:complement(join(2384853..2385726,2384239..2384515,2383496..2383603,2380759..2381944,2379514..2380393,2379278..2379455,2378130..2379216)); ID=FBpp0305706; name=PsGEF-PA; parent=FBgn0264598,FBtr0333526; dbxref=REFSEQ:NP_570002,GB_protein:AAF45778,FlyBase_Annotation_IDs:CG43947-PA,FlyBase:FBpp0305706; MD5=b1976cd22c8bd2d3cef8517a5c96da6a; length=1529; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=X:complement(join(2384853..2385726,2384239..2384515,2383496..2383603,2380759..2381944,2379514..2380393,2379278..2379455,2378130..2379216)); ID=FBpp0305706; name=PsGEF-PA; parent=FBgn0264598,FBtr0333526; dbxref=REFSEQ:NP_570002,GB_protein:AAF45778,FlyBase_Annotation_IDs:CG43947-PA,FlyBase:FBpp0305706; MD5=b1976cd22c8bd2d3cef8517a5c96da6a; length=1529; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of Q7KVY9, Protostome-specific GEF, isoform A OS=Drosophila melanogaster GN=PsGEF PE=4 SV=1 [DROME.fasta.20160308]
  • FBpp0305706 type=protein; loc=X:complement(join(2384853..2385726,2384239..2384515,2383496..2383603,2380759..2381944,2379514..2380393,2379278..2379455,2378130..2379216)); ID=FBpp0305706; name=PsGEF-PA; parent=FBgn0264598,FBtr0333526; dbxref=REFSEQ:NP_570002,GB_protein:AAF45778,FlyBase_Annotation_IDs:CG43947-PA,FlyBase:FBpp0305706; MD5=b1976cd22c8bd2d3cef8517a5c96da6a; length=1529; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=X:complement(join(2384853..2385726,2384239..2384515,2383496..2383603,2380759..2381944,2379514..2380393,2379278..2379455,2378130..2379216)); ID=FBpp0305706; name=PsGEF-PA; parent=FBgn0264598,FBtr0333526; dbxref=REFSEQ:NP_570002,GB_protein:AAF45778,FlyBase_Annotation_IDs:CG43947-PA,FlyBase:FBpp0305706,UniProt/TrEMBL:Q9W4Y9; MD5=b1976cd22c8bd2d3cef8517a5c96da6a; length=1529; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 1529 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEA]
    Biological Process: regulation of Rho protein signal transduction [IEA]
    mushroom body development [IMP]
    Molecular Function: protein binding [IEA]
    Rho guanyl-nucleotide exchange factor activity [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPTMTRMHRH SSSSAVVEES RGRRRGVGVP GVGDANKENF GVHFMSSPFG NASLIALQDL  60
   61 SNVHGKSPQR RSFSEGSGPR QATPQLAALR CLPRTTGGAV ALEDSQLSSS RMGDTTLDRM 120
  121 LDAIIESARK EVRCTKTLPG AGATTSTTIL ADNAEWSETS VHEMEVRTPT HLKRQRVVRR 180
  181 KNPHKTTTIN QTQSHQAKKL EPLQLVPSTK RCLSFSSSSA SSDLDEDEQQ VAKRSSLASP 240
  241 TTTPPSHCTT TTSSISSSSS SNGGADMEAS QRGSIDVSIA FDAKEQQLNV HVIRCRDLQR 300
  301 SHGSGNGSIN AYVKVALSGG AQPPGYGGHS SGGSMSSGYQ RTAVHRHSGR PYFDQRFNFQ 360
  361 ISSGEETAGQ YLQLAVWHRD RHLNSVPVTQ SEWQARVKSG TERRTAERLA KLENAGNEAK 420
  421 RSEFLGCSTF PLNELVHPDS GVSAGSYKLH AQACPPPTSR HSQPKANAGQ DQKQETEAAK 480
  481 DQDKQQDDSP AEMAAAVTVT PQKPVATGSG SGSNSAAMAL NDEVISISID SMGKEDPLLP 540
  541 QQPQQPMKLS KKALHQRDAD ENLFLRFLEL DPPADGNANS TTTQAQATGS QSSASKANES 600
  601 NANHLNNGTS GGRRQSTMPN SGGSSVGGAV RQQQGRTPFT MTKRLTRTEE RGFGFSIVWT 660
  661 HPPRVEKIEA GLSADRCGIL PGDYVIFVDK HNVVTMPEAD VLNLIRSQGS SLTLEIFRRS 720
  721 GAGATTITST DLGQNNVHIS TRLGAAVGLG SEEHTLATTA TGTTTVMSLQ RTTSTRIQPL 780
  781 ANSMSRPATA CSGTTSSIEA AKRRLHLPQV TFSKESIVPV TDNRRRFLLQ LISREQNFTA 840
  841 ALHFGVDRFV QPLGERKDLI SPNDHRTLFQ NIDELLRIAE DILEQLCSSD QQDQEPQMNF 900
  901 ASRVYLSKTT AICAAYKKYC NGIKRADCVL VNKSRQTGSE FIAFITEPAV PRKRPDLTMF 960
  961 IHRPLQHFRE ILKLMQLLAG NCHVDTEEHK NFSTVINELQ AAYREITVSS GLMEPLGEGR1020
 1021 PLLTLQDLES RMVFTKCKPF TLAVQGRQWI FGGDLSRVEG RSVKPYWTLL FSDIIVFAKV1080
 1081 SRDRVLFITE EPIPIANVVD SCFHMRKKTT EFRLTVDPNG RLAESPTGYC APDLTRTPKR1140
 1141 GARRKSLILR APSLELKAVW QNLLQRQIFL VNAALGSTPL SSPLDSPDVL NTLVPLSDIG1200
 1201 LTTASMGSMK LPSLDSIHLK QQQKQQVRLF RSKRLDSGDS YENLQRLASA VRHHCASTTT1260
 1261 SSATQTQSHP QPPLCTTSLP SRTNSPARNQ RHPNGQGHVG GSVPNGVGGV SFGGCNTNSS1320
 1321 CLSSSASLTQ TQTQVHTQTL NHSQTHSQTQ TSVLSLSSCK CLTVIPEVTS EPPVNQHASQ1380
 1381 KLLEFSLSSV GRSFIDESGG VVGGQVSLTT PETPTPNISP TTSQPCNSDA FSNDFVATST1440
 1441 TGKGPNIPLA EFGGSWDLLE LDLQLHEVNL DPSYDTDVEE CIFLGDEEDR EGTEGHGHDE1500
 1501 DSDEDDSVVV DDPFGMLPTR PTPPDSLDL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..254] deduced N/A No confident structure predictions are available.
    2 View Details [255..561] PSI-BLAST 39.045757 Synaptogamin I
    3 View Details [562..732] PSI-BLAST 4.522879 solution structure of the split PH-PDZ Supramodule of alpha-Syntrophin
    4 View Details [733..1183] PSI-BLAST 69.0 No description for 2pz1A was found.
    5 View Details [1184..1340] deduced N/A No confident structure predictions are available.
    6 View Details [1341..1529] MSA 1.130996 View MSA. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle