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Protein Overview: CG4199-PA

General Information:
Name(s) found: CG4199-PA / FBpp0070323 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG4199 (CG4199, FBgn0025628). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:1960468..1967511. It has the cytological map location 2C9-2C10. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: 2 iron, 2 sulfur cluster binding; oxidoreductase activity; FAD binding. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: oxidation reduction; cell redox homeostasis. 4 alleles are reported. No phenotypic data is available. It has 7 annotated transcripts and 7 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 552 amino acids

    Gene Ontology:
    Cellular Component: cytoplasm [IEA]
    Biological Process: cell redox homeostasis [IEA]
    oxidation reduction [IEA]
    Molecular Function: FAD binding [IEA]
    oxidoreductase activity [IEA]
    2 iron, 2 sulfur cluster binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTEESSPDS EYTSAVPVDC RVTDLKENEM KQVDFDEDTR VLLVKQNDRL LAVGAKCTHY  60
   61 GAPLQTGALG LGRVRCPWHG ACFNLENGDI EDFPGLDSLP CYRVEVGNEG QVMLRAKRSD 120
  121 LVNNKRLKNM VRRKPDDQRV FIVVGGGPSG AVAVETIRQE GFTGRLIFVC REDYLPYDRV 180
  181 KISKAMNLEI EQLRFRDEEF YKEYDIELWQ GVAAEKLDTA QKELHCSNGY VVKYDKIYLA 240
  241 TGCSAFRPPI PGVNLENVRT VRELADTKAI LASITPESRV VCLGSSFIAL EAAAGLVSKV 300
  301 QSVTVVGREN VPLKAAFGAE IGQRVLQLFE DNKVVMRMES GIAEIVGNED GKVSEVVLVD 360
  361 DTRLPCDLLI LGTGSKLNTQ FLAKSGVKVN RNGSVDVTDF LESNVPDVYV GGDIANAHIH 420
  421 GLAHDRVNIG HYQLAQYHGR VAAINMCGGV KKLEAVPFFF TLIFGKGIRY AGHGSYKDVI 480
  481 IDGSMEDFKF VAYFINEADT VTAVASCGRD PIVAQFAELI SQGKCLGRGQ IEDPATREDW 540
  541 TKKLGQPLPQ VR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..464] PSI-BLAST 22.221849 Dihydropyrimidine dehydrogenase, N-terminal domain; Dihydropyrimidine dehydrogenase, domain 4; Dihydropyrimidine dehydrogenase, domain 3; Dihydropyrimidine dehydrogenase, domain 2; Dihydropyrimidine dehydrogenase, C-terminal domain
    2 View Details [465..552] PSI-BLAST 64.0 Crystal Structure of Putidaredoxin Reductase from Pseudomonas putida

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • antioxidant activity
    		•  3.37477730756688 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors
    		•  3.17769237742078 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  2.66213649027918 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-CH group of donors
    		•  1.91752931331276 bayes_pls_golite062009
  • binding
    		•  1.75241039340546 bayes_pls_golite062009
  • oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor
    		•  1.6431755180135 bayes_pls_golite062009
  • succinate dehydrogenase (ubiquinone) activity
    		•  1.56913317166386 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor
    		•  1.56913317166386 bayes_pls_golite062009
  • succinate dehydrogenase activity
    		•  1.54010881004951 bayes_pls_golite062009
  • protein binding
    		•  1.40812730845585 bayes_pls_golite062009
  • catalytic activity
    		•  1.13824203225664 bayes_pls_golite062009
  • thioredoxin-disulfide reductase activity
    		•  1.11021120187216 bayes_pls_golite062009
  • NADPH-adrenodoxin reductase activity
    		•  0.684108511779641 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.230666982979064 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  0.150449425695127 bayes_pls_golite062009
  • disulfide oxidoreductase activity
    		•  0.0160065137614933 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.94

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle