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Protein Overview: DAAM-PC

General Information:
Name(s) found: DAAM-PC / FBpp0070230 [FlyBase]
Description(s) found:
Found 12 descriptions.
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  • The gene Dishevelled Associated Activator of Morphogenesis is referred to in FlyBase by the symbol Dmel\DAAM (CG14622, FBgn0025641). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:1183740..1216389. It has the cytological map location 1F2-1F3. Based on sequence similarity, it is predicted to have molecular function</span>: actin binding. There is experimental evidence that it is involved in the biological process</span>: actin filament bundle formation; regulation of tube architecture, open tracheal system; open tracheal system development. 18 alleles are reported. The phenotypes of these alleles are annotated with: taenidial fold; filamentous actin; larval trachea; larval cuticle; larval tracheal system. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1455 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: regulation of tube architecture, open tracheal system [IMP]
    actin cytoskeleton organization [NAS]
    cuticle pattern formation [NAS]
    actin filament bundle assembly [IMP]
    open tracheal system development [IMP]
    Molecular Function: actin binding [IEA][ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSWACCDCTL QSCPIVCINE PDTHSANTEI LQTSPESTLE KPKAAPSGGA STSVTSLNGS  60
   61 CIAINGGIGE GATATASAAT STAAGVTKIT ITSDNGNGNA STSTKAPTTG SSIDGYKNSS 120
  121 LVSITSLNSC SDLSQGSTAT LPISSNSCSG NNVSRHPLSN NNSGSDTSSN NFQERFDFEH 180
  181 WKGLLSDYNC FHGLYRYWTQ CSGRSSSAND NGGGSDQQQS QSNHENGLGS EAGSFYTHNI 240
  241 LGYTFGYPFG LKEDLDGSGN CNSNCNGSSN TNGLGLRKWL SGNTSSNETP LQKHYRHQQK 300
  301 KKMPGFRGRR VWCGCFKDDE PPEICVVEGA FTLQTLTPTQ PMPSVDELDT KFAELVEELD 360
  361 LTAPNKEAML SLPAQKKWQI YCSRKLPLDA ADGPDAAAVT QPPTAEHYIE RLKELVVHIS 420
  421 LSPEDSPSHE LGNRLDGHAA FVDALKTALR TSTHSFVLRF VELDGLPALL DLLLQLDIRV 480
  481 ANSPLHTSLI GCIKALMNNS MGRAHVLAHP TAIDTIARSL AADNIRTKIA ALEILGAVCL 540
  541 VPGGHRKVLQ AMLHFQVFAT ERTRFQSIVN DLDRSTYAYR DNVNLKTALM SFVNAVLNYG 600
  601 PGQENLEFRL HLRYEFLMLG IQPVIDKLRT HENETLDRHL DFFEMVRAED EKEFARRFKE 660
  661 EHVDTKSAGS MFELLRRKLS HSPAYPHMLS LLQHMLLLPY TGHCTEHWLL IDRVVQQIVL 720
  721 QVEQRPNSDL IVDPDDPEKQ LKLAAESPVH DPDVAPLQID VAKLVRLLVK EEQLTQARKR 780
  781 ADELERENFD VQSRLAKKEQ ELDLRMQEKE DLETGLARMR ERLEKESAQH SQAVQRAQTA 840
  841 EMRAEDLQHR LISEQQERAR LERLVTEGSI PDDQKVAGLT GCNGAVSPPP APPMLKAIPP 900
  901 PPPPMAPSMM PPPPPPCPGA PPPPPSMAQT MAPAPPKVDL PKKNVPQPTN PLKSFNWSKL 960
  961 PDAKLQGTVW SELDESKLYN NMELESIDKL FSAYQKNGVS ATDGSYEDLR VTGKAAKQKV1020
 1021 LSVIDGRRAQ NCTILLSKLK MSDMEISKAI LSMDSNEQLQ LDMVEQLLKF TPSAEERALL1080
 1081 DEHSEDIESL ARADRFLYEI SKIPHYEQRL KSLHYKKRFM LTINDLVPRI TSVMEASREV1140
 1141 ARSRRLRKLL ELVLALGNYM NRGARGNASG FRLASLNRLA DTKSSAAKGT TLLHYLVQVI1200
 1201 ERKFKDLLKL EDDIPHVREA SKVSLGEMDK DIQMLRTGLA DVAREIEFHR SSGPAQQGDR1260
 1261 FLPVMREFHA QASVRFAELE DKFQDMKTRF DRAVRLFGED GSVLQPDEFF GIFDSFLAAF1320
 1321 AEARHDNESF RRRQEEEEKR AKQEAELKKR TIERKNKTGL MTSVARNLGL KSGSSNGDPD1380
 1381 SPAKGGDNKG EFDDLISALR TGDVFGEDMA KFKRSRKARV LNGGGSSTGH TSPPRHGSLQ1440
 1441 REESGRERER TVRRQ

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..266] PSI-BLAST 6.154902 Crystal structure of aspartic proteinase from Irpex lacteus
    2 View Details [267..314] PSI-BLAST 3.09691 Endothiapepsin
    3 View Details [315..421] PSI-BLAST 34.154902 Crystal structure of mDIA1 GBD-FH3 in complex with RhoC-GMPPNP
    4 View Details [422..847] PSI-BLAST 28.0 Crystal structure of the dimeric regulatory domain of mouse diaphaneous-related formin (DRF), mDia1
    5 View Details [848..949] FFAS03 1.03 Crystal Structure of Rat Synapsin I C Domain Complexed to Ca.ATP
    6 View Details [950..1455] PSI-BLAST 44.045757 No description for 2j1dG was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • hydrolase activity
    		•  0.314378603018994 bayes_pls_golite062009
  • peptidase activity
    		•  0.14031542953631 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4
    Term Confidence Notes
  • binding
    		•  1.52869107451293 bayes_pls_golite062009
  • protein binding
    		•  0.91858015757355 bayes_pls_golite062009
    5 No functions predicted.
    6 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.97

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle