YRC Logo
PROTEIN SEARCH:
Descriptions Names[Advanced Search]

Protein Overview: Appl-PA

General Information:
Name(s) found: Appl-PA / FBpp0070104 [FlyBase]
Description(s) found:
Found 22 descriptions.
SHOW ALL
  • The gene Ã?&#142;Ã?² amyloid protein precursor-like is referred to in FlyBase by the symbol Dmel\Appl (CG7727, FBgn0000108). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:425652..472172. It has the cytological map location 1B9-1B10. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: neuron projection morphogenesis; response to axon injury; peripheral nervous system development; synapse organization. 31 alleles are reported. The phenotypes of these alleles are annotated with 17 unique terms, many of which group under: nervous system; adult segment; peripheral nervous system; adult mesothoracic segment; organ system; cell component; external compound sense organ; adult brain; wing pouch; primordium; anterior scutellar bristle. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 887 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [IEA]
    extracellular region [IDA]
    plasma membrane [IDA][NAS]
    Biological Process: synapse organization [IMP]
    nervous system development [NAS]
    neuron projection morphogenesis [IMP]
    peripheral nervous system development [IMP]
    response to axon injury [IMP]
    Molecular Function: protein binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCAALRRNLL LRSLWVVLAI GTAQVQAASP RWEPQIAVLC EAGQIYQPQY LSEEGRWVTD  60
   61 LSKKTTGPTC LRDKMDLLDY CKKAYPNRDI TNIVESSHYQ KIGGWCRQGA LNAAKCKGSH 120
  121 RWIKPFRCLG PFQSDALLVP EGCLFDHIHN ASRCWPFVRW NQTGAAACQE RGMQMRSFAM 180
  181 LLPCGISVFS GVEFVCCPKH FKTDEIHVKK TDLPVMPAAQ INSANDELVM NDEDDSNDSN 240
  241 YSKDANEDDL DDEDDLMGDD EEDDMVADEA ATAGGSPNTG SSGDSNSGSL DDINAEYDSG 300
  301 EEGDNYEEDG AGSESEAEVE ASWDQSGGAK VVSLKSDSSS PSSAPVAPAP EKAPVKSESV 360
  361 TSTPQLSASA AAFVAANSGN SGTGAGAPPS TAQPTSDPYF THFDPHYEHQ SYKVSQKRLE 420
  421 ESHREKVTRV MKDWSDLEEK YQDMRLADPK AAQSFKQRMT ARFQTSVQAL EEEGNAEKHQ 480
  481 LAAMHQQRVL AHINQRKREA MTCYTQALTE QPPNAHHVEK CLQKLLRALH KDRAHALAHY 540
  541 RHLLNSGGPG GLEAAASERP RTLERLIDID RAVNQSMTML KRYPELSAKI AQLMNDYILA 600
  601 LRSKDDIPGS SLGMSEEAEA GILDKYRVEI ERKVAEKERL RLAEKQRKEQ RAAEREKLRE 660
  661 EKLRLEAKKV DDMLKSQVAE QQSQPTQSST QSQAQQQQQE KSLPGKELGP DAALVTAANP 720
  721 NLETTKSEKD LSDTEYGEAT VSSTKVQTVL PTVDDDAVQR AVEDVAAAVA HQEAEPQVQH 780
  781 FMTHDLGHRE SSFSLRREFA QHAHAAKEGR NVYFTLSFAG IALMAAVFVG VAVAKWRTSR 840
  841 SPHAQGFIEV DQNVTTHHPI VREEKIVPNM QINGYENPTY KYFEVKE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..147] PSI-BLAST 47.39794 N-terminal domain of the amyloid precursor protein
    2 View Details [148..197] PSI-BLAST 27.30103 Amyloid beta a4 protein copper binding domain (domain 2)
    3 View Details [198..306] deduced N/A No confident structure predictions are available.
    4 View Details [307..665] PSI-BLAST 14.39794 Heavy meromyosin subfragment
    5 View Details [666..810] PSI-BLAST 5.522879 Tropomyosin
    6 View Details [811..887] deduced N/A No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle