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View Structure Prediction Details

Protein: Appl-PA
Organism: Drosophila melanogaster
Length: 887 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Appl-PA.

Description E-value Query
Range
Subject
Range
gi|3929671, gi|3... - gi|3929673|emb|CAA21409.1| EG:65F1.5 [Drosophila melanogaster], gi|3929671|emb|CAA18093.1| EG:65F1.5...
439.0 [0..1] [887..1]

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Predicted Domain #1
Region A:
Residues: [1-147]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MCAALRRNLL LRSLWVVLAI GTAQVQAASP RWEPQIAVLC EAGQIYQPQY LSEEGRWVTD  60
   61 LSKKTTGPTC LRDKMDLLDY CKKAYPNRDI TNIVESSHYQ KIGGWCRQGA LNAAKCKGSH 120
  121 RWIKPFRCLG PFQSDALLVP EGCLFDH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 47.39794
Match: 1mwpA
Description: N-terminal domain of the amyloid precursor protein
Matching Structure (courtesy of the PDB):

Predicted Domain #2
Region A:
Residues: [148-197]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IHNASRCWPF VRWNQTGAAA CQERGMQMRS FAMLLPCGIS VFSGVEFVCC 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 27.30103
Match: 1owtA
Description: Amyloid beta a4 protein copper binding domain (domain 2)
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [198-306]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PKHFKTDEIH VKKTDLPVMP AAQINSANDE LVMNDEDDSN DSNYSKDANE DDLDDEDDLM  60
   61 GDDEEDDMVA DEAATAGGSP NTGSSGDSNS GSLDDINAEY DSGEEGDNY

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [307-665]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EEDGAGSESE AEVEASWDQS GGAKVVSLKS DSSSPSSAPV APAPEKAPVK SESVTSTPQL  60
   61 SASAAAFVAA NSGNSGTGAG APPSTAQPTS DPYFTHFDPH YEHQSYKVSQ KRLEESHREK 120
  121 VTRVMKDWSD LEEKYQDMRL ADPKAAQSFK QRMTARFQTS VQALEEEGNA EKHQLAAMHQ 180
  181 QRVLAHINQR KREAMTCYTQ ALTEQPPNAH HVEKCLQKLL RALHKDRAHA LAHYRHLLNS 240
  241 GGPGGLEAAA SERPRTLERL IDIDRAVNQS MTMLKRYPEL SAKIAQLMND YILALRSKDD 300
  301 IPGSSLGMSE EAEAGILDKY RVEIERKVAE KERLRLAEKQ RKEQRAAERE KLREEKLRL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 14.39794
Match: 1i84S
Description: Heavy meromyosin subfragment
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [666-810]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EAKKVDDMLK SQVAEQQSQP TQSSTQSQAQ QQQQEKSLPG KELGPDAALV TAANPNLETT  60
   61 KSEKDLSDTE YGEATVSSTK VQTVLPTVDD DAVQRAVEDV AAAVAHQEAE PQVQHFMTHD 120
  121 LGHRESSFSL RREFAQHAHA AKEGR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 5.522879
Match: 1c1gA
Description: Tropomyosin
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [811-887]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NVYFTLSFAG IALMAAVFVG VAVAKWRTSR SPHAQGFIEV DQNVTTHHPI VREEKIVPNM  60
   61 QINGYENPTY KYFEVKE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle