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Protein Overview: CG17896-PB

General Information:
Name(s) found: CG17896-PB / FBpp0070087 [FlyBase]
Description(s) found:
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  • gi|74876852|sp|Q7KW39.1|MMSA_DROME RecName: Full=Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; Short=MMSDH; Short=Malonate-semialdehyde dehydrogenase [acylating]; Flags: Precursor [NCBI NR]
  • gi|24638876|ref|NP_569845.2| CG17896, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|22831419|gb|AAF45510.2| CG17896, isoform B [Drosophila melanogaster] [NCBI NR]
  • Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial OS=Drosophila melanogaster GN=CG17896 PE=2 SV=1 [Swiss-Prot]
  • This gene is referred to in FlyBase by the symbol Dmel\CG17896 (CG17896, FBgn0023537). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is X:384820..387527. It has the cytological map location 1B5. Based on sequence similarity, it is predicted to have molecular function</span>: methylmalonate-semialdehyde dehydrogenase (acylating) activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: valine metabolic process; pyrimidine base metabolic process. 5 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • >CG17896-PB translation from_gene[CG17896 EG:171D11.1 FBgn0023537] seq_release:3 mol_weight=55973 cds_boundaries:(X:248,537..250,855[-]) aa_length:520 transcript_info:[CG17896-RB seq_release:3] gene_info:[gene symbol:EG:171D11.1 FBgn0023537 gene_bounda [hmr_yeast5_DM3-1_pombe.fasta]
  • (AAF45510) CG17896-PB [DrosMelano7227.FASTAC.txt]
  • CG17896-PB, isoform B [Drosophila melanogaster]gi|24638876|ref|NP_569845.2| CG17896-PB [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=X:complement(385129..386661,387421..387450); ID=FBpp0070087; name=CG17896-PB; parent=FBgn0023537,FBtr0070092; dbxref=FlyBase:FBpp0070087,FlyBase_Annotation_IDs:CG17896-PB,GB_protein:AAF45510.2,REFSEQ:NP_569845,GB_protein:AAF45510; MD5=fa [fly-100309-contam.fasta]
  • Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial precursor (MMSDH) (Malonate-semialdehyde dehydrogenase [acylating]) [nr-271106-contam.fasta]
  • CG17896-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=X:complement(385129..386661,387421..387450); ID=FBpp0070087; name=CG17896-PB; parent=FBgn0023537,FBtr0070092; dbxref=FlyBase:FBpp0070087,FlyBase_Annotation_IDs:CG17896-PB,GB_protein:AAF45510.2,REFSEQ:NP_569845,GB_protein:AAF45510; MD5=fa5e3b71de702f6d4acbc0db138c517d; length=520; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=X:complement(385129..386661,387421..387450); ID=FBpp0070087; name=CG17896-PB; parent=FBgn0023537,FBtr0070092; dbxref=FlyBase:FBpp0070087,FlyBase_Annotation_IDs:CG17896-PB,GB_protein:AAF45510.2,REFSEQ:NP_569845,GB_protein:AAF45510; MD5=fa5e3b71de702f6d4acbc0db138c517d; length=520; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Probable methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial OS=Drosophila melanogaster GN=CG17896 PE=1 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=X:complement(385129..386661,387421..387450); ID=FBpp0070087; name=CG17896-PB; parent=FBgn0023537,FBtr0070092; dbxref=FlyBase:FBpp0070087,FlyBase_Annotation_IDs:CG17896-PB,GB_protein:AAF45510.2,REFSEQ:NP_569845,GB_protein:AAF45510,FlyMine:FBpp0070087,modMine:FBpp0070087; MD5=fa5e3b71de702f6d4acbc0db138c517d; length=520; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=X:complement(join(493388..493417,491096..492628)); ID=FBpp0070087; name=CG17896-PB; parent=FBgn0023537,FBtr0070092; dbxref=FlyBase:FBpp0070087,FlyBase_Annotation_IDs:CG17896-PB,GB_protein:AAF45510.2,REFSEQ:NP_569845,GB_protein:AAF45510,FlyMine:FBpp0070087,modMine:FBpp0070087; MD5=fa5e3b71de702f6d4acbc0db138c517d; length=520; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=X:complement(join(493388..493417,491096..492628)); ID=FBpp0070087; name=CG17896-PB; parent=FBgn0023537,FBtr0070092; dbxref=FlyBase:FBpp0070087,FlyBase_Annotation_IDs:CG17896-PB,GB_protein:AAF45510.2,REFSEQ:NP_569845,GB_protein:AAF45510,FlyMine:FBpp0070087,modMine:FBpp0070087; MD5=fa5e3b71de702f6d4acbc0db138c517d; length=520; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0070087 type=protein; loc=X:complement(join(493388..493417,491096..492628)); ID=FBpp0070087; name=CG17896-PB; parent=FBgn0023537,FBtr0070092; dbxref=FlyBase:FBpp0070087,FlyBase_Annotation_IDs:CG17896-PB,GB_protein:AAF45510.2,REFSEQ:NP_569845,GB_protein:AAF45510,FlyMine:FBpp0070087,modMine:FBpp0070087; MD5=fa5e3b71de702f6d4acbc0db138c517d; length=520; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=X:complement(join(493388..493417,491096..492628)); ID=FBpp0070087; name=CG17896-PB; parent=FBgn0023537,FBtr0070092; dbxref=FlyBase:FBpp0070087,FlyBase_Annotation_IDs:CG17896-PB,GB_protein:AAF45510.2,REFSEQ:NP_569845,GB_protein:AAF45510,UniProt/Swiss-Prot:Q7KW39,FlyMine:FBpp0070087,modMine:FBpp0070087; MD5=fa5e3b71de702f6d4acbc0db138c517d; length=520; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 520 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [ISS]
    Biological Process: pyrimidine base metabolic process [ISS]
    oxidation reduction [IEA]
    valine metabolic process [ISS]
    Molecular Function: methylmalonate-semialdehyde dehydrogenase (acylating) activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLVRLIGAE ARHLAKRSYS SAAPTTKLFI DGKFVESKTN EWIDVHDPAT NQVVTRVPKA  60
   61 TQAEMQAALE SNKKAFRSWS NQSILTRQQV MFKLQALIKE NMGELAKNIT KEQGKTLADA 120
  121 EGDVLRGLQV VEHCCSIPSL QMGETVANVA RDMDTYSLVL PLGVTAGVAP FNFPAMIPLW 180
  181 MFPVAITTGN TMLLKPSERV PGATMLLMEL LNEAGCPPGV VNVIHGQHDA VNFICDAPEI 240
  241 KAVSFVGSDQ AGKYIYERAG KNGKRVQSNM GAKNHGIILG DANKENTLNQ LAGAAFGAAG 300
  301 QRCMALSTAV FVGDAQAWIP DLVERAQKLK VNAGHVPGTD VGPVISAASR QRINDLIESG 360
  361 VKEGAKLILD GRKITVPGYE DGYFVGPTIL SDVTPSMKCY TEEIFGPVLV ILKADTLDDA 420
  421 IGIVNANPYG NGTAVFTTNG AAARKFVNEI DAGQVGVNVP IPVPLPMFSF TGTRGSFRGD 480
  481 HHFYGKQGIK FYTQTKTVTQ LWRKTDVTHT QAAVAMPTMK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..520] PSI-BLAST 145.0 Crystal structure of methylmalonate semialdehyde dehydrogenase from Bacillus subtilis


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.71

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
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