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Protein Overview: plexA-PB, plexA-PC

General Information:
Name(s) found: plexA-PB / FBpp0088289 [FlyBase]
plexA-PC / FBpp0088288 [FlyBase]
Description(s) found:
Found 33 descriptions.
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  • The gene plexin A is referred to in FlyBase by the symbol Dmel\plexA (CG11081, FBgn0025741). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 4:1034030..1047720. It has the cytological map location 102F5-102F6. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: axon guidance; axon midline choice point recognition. 10 alleles are reported. The phenotypes of these alleles are annotated with: ventral nerve cord; intersegmental nerve; longitudinal connective; embryonic central nervous system; abdominal segmental nerve; abdominal intersegmental nerve; transverse nerve. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
  • The gene plexin A is referred to in FlyBase by the symbol Dmel\plexA (CG11081, FBgn0025741). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 4:1034030..1047720. It has the cytological map location 102F5-102F6. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: axon guidance; axon midline choice point recognition. 10 alleles are reported. The phenotypes of these alleles are annotated with: ventral nerve cord; intersegmental nerve; longitudinal connective; embryonic central nervous system; abdominal segmental nerve; abdominal intersegmental nerve; transverse nerve. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1505 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEA]
    intracellular [IEA]
    Biological Process: motor axon guidance [NAS]
    signal transduction [IEA]
    axon guidance [IMP]
    axon midline choice point recognition [IMP]
    Molecular Function: protein binding [IPI]
    semaphorin receptor activity [ISS][TAS]
    axon guidance receptor activity [NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFNTKLTSVA ATSTSGYTVV FVGTSDGFLK KVVIESSSIA NEYASFAVDL GSEINRDMQF  60
   61 DNQNLYIYVM SKTKVSKVKV FDCSDYKTCG DCLGARDPYC GWCSLENKCS PRSNCQDDAN 120
  121 DPLYWVSYKT GKCTTITSVV PHQLQRTTAR TLELIIDHLP QLKENLICAF TTEDKALFTN 180
  181 ATKKRNGVNC TTPRTDMLPQ IEQGKHHFTA KLSVRTRNGP DLVSTDFTFF DCSTHSSCTR 240
  241 CVSSEFPCDW CVEAHRCTHD TAENCRNDIL VTGVSRIGPS YRSGPGFCPT INATGDGSEV 300
  301 LVAGGTSKSI KVKVHIIGQF IVQTRFVCQF NIEGRVTSLN AQLLGDTIYC DSMEFQYTSR 360
  361 SPNLTATFAV IWGGSKPLDN PHNIHVVIYR CREMADSCGI CLALSEKYNC GWCSSTNTCE 420
  421 VEEQCNKNKE GKTDWLNRSE ICPNPEIHTF QPKTGPWEGG TNITIRGINL GKNYNDIYSG 480
  481 VRIAGINCMP FPQFYIDTKQ IVCTVDSPGE QMYRNGKIVV QIGDYRGESK EDYEFVDPKI 540
  541 LDFNPKFGPT SGGTEIHITG KHLNAGSRIQ ASINDHLPCK ILSTDSSQAI CRTSASPGII 600
  601 EGRLKMSFDN GPREFNDYNF KYVLDPTVEH VSSGPSGQIK VPKGIPAGGI RISVTGTQFT 660
  661 SIQNPNIYVV YNGEMYASPC RVQSDTEMEC ASPVVDVDSH VIEAERPILL EYGFLMDNVL 720
  721 RVQNLSKVHN NHFELYPNPE YFIFEERVKY FKSEYLTING RNLDRACKES DVEVKIGNGF 780
  781 CNITSLSRQQ LTCRPPSEAT ATKSMNGPEV IVRIGTSLEY RIGILSYESS NIILDWGENV 840
  841 IFAVIATIVI LLLIFVALLV AYKKKSSESS RVLRNMQEQM DILELRVAAE CKEAFAELQT 900
  901 EMTDLTGDLT SGGIPFLDYR SYAMKILFPN HEDHIVLQWE RPELLRKEKG LRIFGQLIMN 960
  961 KTFLLLFIRT LESNRYFSMR ERVNVASLIM VTLQSKLEYC TDILKTLLGD LIEKCIEGKS1020
 1021 HPKLLLRRTE SVAEKMLSAW FTFLLYKFLK ECAGEPLYML FRAVKGQVDK GPVDACTHEA1080
 1081 RYSLSEEKLI RQSIDFRPMN VYASIIQQPI FCNNLDMLPS HTENVSVKVL DCDTIGQVKE1140
 1141 KCLETIYRNI PSSQRPRKDD LDLEWRTGAT GRVILYDEDV TSKTESEWKK LNTLQHYNVP1200
 1201 DGAGLSLVPK QSSIYNFSIL SDKNEKSHKY ETLNISKYTS SSPTFSRAGS PLNNDMHENG1260
 1261 LRYWHLVKHH DSDMQKEGER VNKLVSEIYL TRLLATKGTL QKFVDDLFET IFSTAHRGSA1320
 1321 LPLAIKYMFD FLDDQAQLHG ITDPEVVHTW KSNSLPLRFW VNLIKNPNFV FDIHKSNIVD1380
 1381 SCLSVVAQTF MDSCSTSDHR LGKDSPSSKL LYAKDIPEYR KWVDRYYRDI RDMSPISDQD1440
 1441 MNAMLAEESR LHTTEFNTNC ALHELYTYAV KYNEQLTVTL EEDEFSQKQR LAFKLEQVHN1500
 1501 IMSSE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..108] PSI-BLAST 24.0 The ligand-binding face of the semaphorins revealed by the high resolution crystal structure of SEMA4D
    2 View Details [109..484] PSI-BLAST 11.39794 Low density lipoprotein (LDL) receptor YWTD domain; Low density lipoprotein (LDL) receptor, different EGF domains; Ligand-binding domain of low-density lipoprotein receptor
    3 View Details [485..635] PSI-BLAST 24.39794 No description for 2uzxB was found.
    4 View Details [636..865] FFAS03 2.18 No description for 2uzxB was found.
    5 View Details [866..928] deduced N/A No confident structure predictions are available.
    6 View Details [929..1039] PSI-BLAST 10.221849 Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met in complex with the microbial alkaloid K-252a
    7 View Details [1040..1236] PSI-BLAST 41.39794 No description for 2r2oA was found.
    8 View Details [1237..1505] FFAS03 1.49 GAP related domain of neurofibromin

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • protein binding
    		•  2.30744405151563 bayes_pls_golite062009
  • receptor binding
    		•  1.70177010329948 bayes_pls_golite062009
  • binding
    		•  1.63967303762968 bayes_pls_golite062009
  • ErbB-3 class receptor binding
    		•  1.18463863965142 bayes_pls_golite062009
  • growth factor activity
    		•  0.59278308192712 bayes_pls_golite062009
  • ErbB-2 class receptor binding
    		•  0.437338899624441 bayes_pls_golite062009
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8
    Term Confidence Notes
  • protein binding
    		•  1.47356170396493 bayes_pls_golite062009
  • enzyme regulator activity
    		•  1.39082200655299 bayes_pls_golite062009
  • GTPase regulator activity
    		•  1.32712330053994 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  1.32332610568436 bayes_pls_golite062009
  • GTPase activator activity
    		•  1.26194925603349 bayes_pls_golite062009
  • enzyme activator activity
    		•  1.25756739840692 bayes_pls_golite062009
  • binding
    		•  0.90203495506529 bayes_pls_golite062009
  • small GTPase regulator activity
    		•  0.889119908410775 bayes_pls_golite062009
  • Ras GTPase activator activity
    		•  0.811555335811836 bayes_pls_golite062009
  • Rho GTPase activator activity
    		•  0.539480685576633 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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