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Protein Overview: lgs-PA

General Information:
Name(s) found: lgs-PA / FBpp0088180 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene legless is referred to in FlyBase by the symbol Dmel\lgs (CG2041, FBgn0039907). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 4:457577..464533. It has the cytological map location 102B8-102C1. There is experimental evidence that it has the molecular function</span>: protein binding; beta-catenin binding. There is experimental evidence that it is involved in the biological process</span>: positive regulation of Wnt receptor signaling pathway; regulation of Wnt receptor signaling pathway; imaginal disc-derived wing margin morphogenesis; Wnt receptor signaling pathway; segment polarity determination. 20 alleles are reported. The phenotypes of these alleles are annotated with: wing margin; embryonic/first instar larval cuticle; leg; antenna; sternite; wing; imaginal disc. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1469 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IDA][NAS]
    Biological Process: Wnt receptor signaling pathway [IMP][NAS]
    segment polarity determination [IMP]
    imaginal disc-derived wing margin morphogenesis [IMP]
    regulation of Wnt receptor signaling pathway [IPI]
    positive regulation of Wnt receptor signaling pathway [IGI]
    Molecular Function: protein binding [IPI]
    beta-catenin binding [IPI]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLSTTMPRSP TQQQPQPNSD ASSTSASGSN PGAAIGNGDS AASRSSPKTL NSEPFSTLSP  60
   61 DQIKLTPEEG TEKSGLSTSD KAATGGAPGS GNNLPEGQTM LRQNSTSTIN SCLVASPQNS 120
  121 SEHSNSSNVS ATVGLTQMVD CDEQSKKNKC SVKDEEAEIS SNKAKGQAAG GGCETGSTSS 180
  181 LTVKEEPTDV LGSLVNMKKE ERENHSPTMS PVGFGSIGNA QDNSATPVKI ERISNDSTTE 240
  241 KKGSSLTMNN DEMSMEGCNQ LNPDFINESL NNPAISSILV SGVGPIPGIG VGAGTGNLLT 300
  301 ANANGISSGS SNCLDYMQQQ NHIFVFSTQL ANKGAESVLS GQFQTIIAYH CTQPATKSFL 360
  361 EDFFMKNPLK INKLQRHNSV GMPWIGMGQV GLTPPNPVAK ITQQQPHTKT VGLLKPQFNQ 420
  421 HENSKRSTVS APSNSFVDQS DPMGNETELM CWEGGSSNTS RSGQNSRNHV DSISTSSESQ 480
  481 AIKILEAAGV DLGQVTKGSD PGLTTENNIV SLQGVKVPDE NLTPQQRQHR EEQLAKIKKM 540
  541 NQFLFPENEN SVGANVSSQI TKIPGDLMMG MSGGGGGSII NPTMRQLHMP GNAKSELLSA 600
  601 TSSGLSEDVM HPGDVISDMG AVIGCNNNQK TSVQCGSGVG VVTGTTAAGV NVNMHCSSSG 660
  661 APNGNMMGSS TDMLASFGNT SCNVIGTAPD MSKEVLNQDS RTHSHQGGVA QMEWSKIQHQ 720
  721 FFEERLKGGK PRQVTGTVVP QQQTPSGSGG NSLNNQVRPL QGPPPPYHSI QRSASVPIAT 780
  781 QSPNPSSPNN LSLPSPRTTA AVMGLPTNSP SMDGTGSLSG SVPQANTSTV QAGTTTVLSA 840
  841 NKNCFQADTP SPSNQNRSRN TGSSSVLTHN LSSNPSTPLS HLSPKEFESF GQSSAGDNMK 900
  901 SRRPSPQGQR SPVNSLIEAN KDVRFAASSP GFNPHPHMQS NSNSALNAYK MGSTNIQMER 960
  961 QASAQGGSVQ FSRRSDNIPL NPNSGNRPPP NKMTQNFDPI SSLAQMSQQL TSCVSSMGSP1020
 1021 AGTGGMTMMG GPGPSDINIE HGIISGLDGS GIDTINQNNC HSMNVVMNSM GPRMLNPKMC1080
 1081 VAGGPNGPPG FNPNSPNGGL RENSIGSGCG SANSSNFQGV VPPGARMMGR MPVNFGSNFN1140
 1141 PNIQVKASTP NTIQYMPVRA QNANNNNNNG ANNVRMPPSL EFLQRYANPQ MGAVGNGSPI1200
 1201 CPPSASDGTP GMPGLMAGPG AGGMLMNSSG EQHQNKITNN PGASNGINFF QNCNQMSIVD1260
 1261 EEGGLPGHDG SMNIGQPSMI RGMRPHAMRP NVMGARMPPV NRQIQFAQSS DGIDCVGDPS1320
 1321 SFFTNASCNS AGPHMFGSAQ QANQPKTQHI KNIPSGMCQN QSGLAVAQGQ IQLHGQGHAQ1380
 1381 GQSLIGPTNN NLMSTAGSVS ATNGVSGINF VGPSSTDLKY AQQYHSFQQQ LYATNTRSQQ1440
 1441 QQHMHQQHQS NMITMPPNLS PNPTFFVNK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..110] deduced N/A No confident structure predictions are available.
    2 View Details [111..274] MSA 2.098993 View MSA. No confident structure predictions are available.
    3 View Details [275..429] deduced N/A No confident structure predictions are available.
    4 View Details [430..1396] PSI-BLAST 60.39794 No description for 1y0fB was found.
    5 View Details [1397..1469] FFAS03 0.979 cks1


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.95

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle