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Protein Overview: tmod-PB

General Information:
Name(s) found: tmod-PB / FBpp0085025 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene tropomodulin is referred to in FlyBase by the symbol Dmel\tmod (CG1539, FBgn0082582). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:26358336..26404627. It has the cytological map location 99F7-99F8. Based on sequence similarity, it is predicted to have molecular function</span>: actin binding. Based on sequence similarity, it is predicted to be involved in the biological process</span>: cytoskeleton organization. 24 alleles are reported. The phenotypes of these alleles are annotated with: striated muscle thin filament; indirect flight muscle. It has 12 annotated transcripts and 12 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 403 amino acids

    Gene Ontology:
    Cellular Component: cytoskeleton [IEA]
    Biological Process: cytoskeleton organization [ISS]
    Molecular Function: actin binding [ISS]
    tropomyosin binding [IEA][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MESALPVAEF QQIKLRPVPK VKRRAPQPPV SLRLKHKNTS ATTKTTTLTT PAKLYGKDLS  60
   61 EYDDVDVESL LAQLSPEEIT ILAKEVDPDD NFLPPDQRNS YECTKEATGP LNRKQLIEHI 120
  121 NKQAIETPDQ PEFEPFVQGK VRGKKWVPPP RDARDIEAEE QIAIDMGEEY EHALNDATQE 180
  181 EIIDLAAILG FHSMMNQDQY HASLLNKGQP VGLGWDGITK STQQKLFPMD PPNNTDVEES 240
  241 IKRVKDDDSK LIDLNLNNIK NISDEKLEQL FAALPQNEHL EVLSLTNVGL TDKTALLLAA 300
  301 AIEKSKTLRV LNVETNFISP PVIVKLVQAL LKCHTIEEFR ASNQRSAVLG NKIEMEITDL 360
  361 VEKNSSLLRL GLHLEFNDAR HRVAAHLQRN IDRIRVKRLN QRK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..206] Pfam 7.744727 No description for PF03250.5 was found. No confident structure predictions are available.
    2 View Details [207..403] PSI-BLAST 21.522879 Tropomodulin C-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2
    Term Confidence Notes
  • microtubule minus-end binding
    		•  7.70887263207962 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  5.04595324782806 bayes_pls_golite062009
  • actin binding
    		•  4.98528043340021 bayes_pls_golite062009
  • tropomyosin binding
    		•  2.80631683562112 bayes_pls_golite062009
  • binding
    		•  2.665591019824 bayes_pls_golite062009
  • protein binding
    		•  2.66138763326419 bayes_pls_golite062009
  • myosin binding
    		•  1.32546860780591 bayes_pls_golite062009
  • tubulin binding
    		•  1.00494145757097 bayes_pls_golite062009
  • microtubule binding
    		•  0.854246295331667 bayes_pls_golite062009
  • catalytic activity
    		•  0.143741655309638 bayes_pls_golite062009
  • Ras GTPase activator activity
    		•  0.0986232864289136 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle