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Protein Overview: PH4alphaNE1-PA

General Information:
Name(s) found: PH4alphaNE1-PA / FBpp0085050 [FlyBase]
Description(s) found:
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  • gi|7301952|gb|AAF57058.1| prolyl-4-hydroxylase-alpha NE1 [Drosophila melanogaster] [NCBI NR]
  • gi|24651420|ref|NP_733374.1| prolyl-4-hydroxylase-alpha NE1 [Drosophila melanogaster] [NCBI NR]
  • The gene prolyl-4-hydroxylase-alpha NE1 is referred to in FlyBase by the symbol Dmel\PH4Ã?&#142;Ã?±NE1 (CG9728, FBgn0039780). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:26322473..26325944. It has the cytological map location 99F6. Based on sequence similarity, it is predicted to have molecular function</span>: procollagen-proline 4-dioxygenase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: peptidyl-proline hydroxylation to 4-hydroxy-L-proline. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG9728-PA translation from_gene[CG9728 PH4alphaNE1 FBgn0039780] seq_release:3 mol_weight=61381 cds_boundaries:(3R:26,311,861..26,315,310[-]) aa_length:537 transcript_info:[CG9728-RA seq_release:3] gene_info:[gene symbol:PH4alphaNE1 FBgn0039780 gene_bo [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9VA64) CG9728 protein [DrosMelano7227.FASTAC.txt]
  • (AE003774) CG9728 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG9728-PA [Drosophila melanogaster]gi|24651420|ref|NP_733374.1| CG9728-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:complement(26322492..26322592,26322806..26322971,26323035..26323538,26323595..26323743,26323817..26324028,26324552..26324699,26324758..26324912,26325766..26325944); ID=FBpp0085050; name=PH4alphaNE1-PA; parent=FBgn0039780,FBtr0085688; [fly-100309-contam.fasta]
  • CG9728-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • prolyl-4-hydroxylase-alpha NE1 CG9728-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3R:complement(26322492..26322592,26322806..26322971,26323035..26323538,26323595..26323743,26323817..26324028,26324552..26324699,26324758..26324912,26325766..26325944); ID=FBpp0085050; name=PH4alphaNE1-PA; parent=FBgn0039780,FBtr0085688; dbxref=FlyBase:FBpp0085050,FlyBase_Annotation_IDs:CG9728-PA,GB_protein:AAF57058.1,REFSEQ:NP_733374,GB_protein:AAF57058; MD5=32dd79705b53fe2a165e604a11b5762c; length=537; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:complement(26322492..26322592,26322806..26322971,26323035..26323538,26323595..26323743,26323817..26324028,26324552..26324699,26324758..26324912,26325766..26325944); ID=FBpp0085050; name=PH4alphaNE1-PA; parent=FBgn0039780,FBtr0085688; dbxref=FlyBase:FBpp0085050,FlyBase_Annotation_IDs:CG9728-PA,GB_protein:AAF57058.1,REFSEQ:NP_733374,GB_protein:AAF57058; MD5=32dd79705b53fe2a165e604a11b5762c; length=537; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Prolyl-4-hydroxylase-alpha NE1 OS=Drosophila melanogaster GN=PH4alphaNE1 PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=3R:complement(26322492..26322592,26322806..26322971,26323035..26323538,26323595..26323743,26323817..26324028,26324552..26324699,26324758..26324912,26325766..26325944); ID=FBpp0085050; name=PH4alphaNE1-PA; parent=FBgn0039780,FBtr0085688; dbxref=FlyBase:FBpp0085050,FlyBase_Annotation_IDs:CG9728-PA,GB_protein:AAF57058.1,REFSEQ:NP_733374,GB_protein:AAF57058,FlyMine:FBpp0085050,modMine:FBpp0085050; MD5=32dd79705b53fe2a165e604a11b5762c; length=537; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3R:complement(join(30500044..30500222,30499036..30499190,30498830..30498977,30498095..30498306,30497873..30498021,30497313..30497816,30497084..30497249,30496770..30496870)); ID=FBpp0085050; name=PH4alphaNE1-PA; parent=FBgn0039780,FBtr0085688; dbxref=FlyBase:FBpp0085050,FlyBase_Annotation_IDs:CG9728-PA,GB_protein:AAF57058.1,REFSEQ:NP_733374,GB_protein:AAF57058,FlyMine:FBpp0085050,modMine:FBpp0085050; MD5=32dd79705b53fe2a165e604a11b5762c; length=537; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:complement(join(30500044..30500222,30499036..30499190,30498830..30498977,30498095..30498306,30497873..30498021,30497313..30497816,30497084..30497249,30496770..30496870)); ID=FBpp0085050; name=PH4alphaNE1-PA; parent=FBgn0039780,FBtr0085688; dbxref=FlyBase:FBpp0085050,FlyBase_Annotation_IDs:CG9728-PA,GB_protein:AAF57058.1,REFSEQ:NP_733374,GB_protein:AAF57058,FlyMine:FBpp0085050,modMine:FBpp0085050; MD5=32dd79705b53fe2a165e604a11b5762c; length=537; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FI16820p1 OS=Drosophila melanogaster GN=PH4alphaNE1 PE=2 SV=1 [DROME.fasta.20160308]
  • FBpp0085050 type=protein; loc=3R:complement(join(30500044..30500222,30499036..30499190,30498830..30498977,30498095..30498306,30497873..30498021,30497313..30497816,30497084..30497249,30496770..30496870)); ID=FBpp0085050; name=PH4alphaNE1-PA; parent=FBgn0039780,FBtr0085688; dbxref=FlyBase:FBpp0085050,FlyBase_Annotation_IDs:CG9728-PA,GB_protein:AAF57058.1,REFSEQ:NP_733374,GB_protein:AAF57058,FlyMine:FBpp0085050,modMine:FBpp0085050; MD5=32dd79705b53fe2a165e604a11b5762c; length=537; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:complement(join(30500044..30500222,30499036..30499190,30498830..30498977,30498095..30498306,30497873..30498021,30497313..30497816,30497084..30497249,30496770..30496870)); ID=FBpp0085050; name=PH4alphaNE1-PA; parent=FBgn0039780,FBtr0085688; dbxref=FlyBase:FBpp0085050,FlyBase_Annotation_IDs:CG9728-PA,GB_protein:AAF57058.1,REFSEQ:NP_733374,GB_protein:AAF57058,UniProt/TrEMBL:Q9VA64,FlyMine:FBpp0085050,modMine:FBpp0085050; MD5=32dd79705b53fe2a165e604a11b5762c; length=537; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 537 amino acids

    Gene Ontology:
    Cellular Component: endoplasmic reticulum [IEA]
    procollagen-proline 4-dioxygenase complex [IC]
    Biological Process: oxidation reduction [IEA]
    peptidyl-proline hydroxylation to 4-hydroxy-L-proline [ISS]
    Molecular Function: procollagen-proline 4-dioxygenase activity [ISS]
    L-ascorbic acid binding [IEA]
    oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [IEA]
    iron ion binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRGLVLLVGL IFLLAQGSLA SDYFSSITGL EDLLHTEQYL TRELRSKVNA IQTALQQLES  60
   61 ELSSIEKEHT MAASDTENYL TNPVNVYRLM KRLHTDWSLM EGRVQLMAEE MNFNATREYG 120
  121 LSYPSQEDVE GAALALVRLQ STYKLDVAQV AQGILNGVKY GSDMSWQDCF ELGQQLFEME 180
  181 DYNNTKVWLR ESMERLRRQT SHAPSHLAPT SGPDTVTLNK MEATAKSLFQ LGDFDTAFEL 240
  241 SQRVLQFDPK RIRNWHLGDK GTAPPEDIDD VYLPKHSDSY SLSQEFAKYE KVCRGEVHPI 300
  301 VRQELRCRYS RGNHPYRFLA PLKLEEHSLD PYVATFHDIL SPGKISQLRE MAVPRMHRST 360
  361 VNPLPGGQLK KSAFRVSKNA WLAYESHPTM VGMLRDLKDA TGLDTTFCEQ LQVANYGVGG 420
  421 HYEPHWDFFR DPNHYPAEEG NRIATAIFYL SEVEQGGATA FPFLDIAVKP QLGNVLFWYN 480
  481 LHRSLDKDYR TKHAGCPVLK GSKWIGNVWI HEVTQTFARP CDVFRDHEVS LEYEIIK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..164] Pfam 60.721246 No description for PF08336.2 was found. No confident structure predictions are available.
    2 View Details [165..279] PSI-BLAST 15.30103 Designed protein cTPR3
    3 View Details [280..537] FFAS03 5.26 No description for 2hbtA was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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