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Protein Overview: Gycalpha99B-PA

General Information:
Name(s) found: Gycalpha99B-PA / FBpp0084819 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene Guanylyl cyclase Ã?&#142;Ã?±-subunit at 99B is referred to in FlyBase by the symbol Dmel\GycÃ?&#142;Ã?±99B (CG1912, FBgn0013972). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:25508224..25511502. It has the cytological map location 99B7. There is experimental evidence that it has the molecular function</span>: guanylate cyclase activity. There is experimental evidence that it is involved in the biological process</span>: rhodopsin mediated phototransduction; positive phototaxis. 10 alleles are reported. The phenotypes of these alleles are annotated with: photoreceptor cell R7; photoreceptor cell R8. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 676 amino acids

    Gene Ontology:
    Cellular Component: guanylate cyclase complex, soluble [IDA][NAS]
    cytoplasm [NAS]
    Biological Process: cGMP biosynthetic process [IEA]
    intracellular signaling pathway [IEA]
    rhodopsin mediated phototransduction [IMP]
    positive phototaxis [IMP]
    Molecular Function: guanylate cyclase activity [IDA][NAS]
    heme binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MACPFFRRAD SLTRQPSVIA EPGGHWALED EELSDDALTL THLQMAIQLL TAPSNEDLNT  60
   61 AVTSLVAKYR QNWPNIHKLK LDPQTFKSCA NYDYLADIQE LLLKMDEASA SEILVLLGEE 120
  121 LITCCCTGII ERAFRCLGTD LQEFLGSLDG VYDVLKLQEE DVTDTGFVCA GEGELIFTSE 180
  181 RPVIAWLLLG SLKALTRMLY KVDVNIKIEP VEGDARRYRY LFSLVKDNSQ TMLMGRPTSV 240
  241 SKTIPETVQR SNSSNASDLQ MNSSSFCKMF PWHFIMNEQL ELVQLGRGFS KLYKPYMADF 300
  301 GCQATTYFDF KRPKGLTMKF RDIVRRTYTP FLIGLNNPPG AVDFPAIGLE IKGQMVHCPE 360
  361 SNSLLFIGSP FLDGLDGLTC NGLFISDIPL HDATREVILV GEQARAQDGL RRRMDKIKNS 420
  421 IEEANSAVTK ERKKNVSLLH LIFPAEIAEK LWLGSSIDAK TYPDVTILFS DIVGFTSICS 480
  481 RATPFMVISM LEGLYKDFDE FCDFFDVYKV ETIGDAYCVA SGLHRASIYD AHKVAWMALK 540
  541 MIDACSKHIT HDGEQIKMRI GLHTGTVLAG VVGRKMPRYC LFGHSVTIAN KFESGSEALK 600
  601 INVSPTTKDW LTKHEGFEFE LQPRDPSFLP KEFPNPGGTE TCYFLESFRN PALDSELPLV 660
  661 EHINVSMKTI SEGGDA

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..213] PSI-BLAST 30.69897 No description for 2o09A was found.
    2 View Details [214..349] MSA 1.502996 View MSA. No confident structure predictions are available.
    3 View Details [350..458] deduced N/A No confident structure predictions are available.
    4 View Details [459..676] PSI-BLAST 51.30103 Crystal structure of a mutant form of the mycobacterial adenylyl cyclase Rv1625c


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle