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Protein Overview: tobi-PA

General Information:
Name(s) found: tobi-PA / FBpp0084221 [FlyBase]
Description(s) found:
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  • gi|78214212|gb|ABB36428.1| RE74917p [Drosophila melanogaster] [NCBI NR]
  • gi|7301333|gb|AAF56462.1| CG11909 [Drosophila melanogaster] [NCBI NR]
  • gi|24650054|ref|NP_651391.1| CG11909 [Drosophila melanogaster] [NCBI NR]
  • The gene target of brain insulin is referred to in FlyBase by the symbol Dmel\tobi (CG11909, FBgn0261575). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:21170483..21172634. It has the cytological map location 96D2. Based on sequence similarity, it is predicted to have molecular function</span>: alpha-glucosidase activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: carbohydrate metabolic process. 6 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG11909-PA translation from_gene[CG11909 CG11909 FBgn0039330] seq_release:3 mol_weight=74598 cds_boundaries:(3R:21,161,238..21,163,265[-]) aa_length:657 transcript_info:[CG11909-RA seq_release:3] gene_info:[gene symbol:CG11909 FBgn0039330 gene_boundar [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9VBR6) CG11909 protein [DrosMelano7227.FASTAC.txt]
  • (AE003751) CG11909 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG11909-PA [Drosophila melanogaster]gi|24650054|ref|NP_651391.1| CG11909-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:complement(21170578..21170777,21170835..21172608); ID=FBpp0084221; name=CG11909-PA; parent=FBgn0039330,FBtr0084847; dbxref=FlyBase:FBpp0084221,FlyBase_Annotation_IDs:CG11909-PA,GB_protein:AAF56462.1,REFSEQ:NP_651391,GB_protein:AAF5646 [fly-100309-contam.fasta]
  • CG11909-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • RE74917p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3R:complement(21170578..21170777,21170835..21172608); ID=FBpp0084221; name=CG11909-PA; parent=FBgn0039330,FBtr0084847; dbxref=FlyBase:FBpp0084221,FlyBase_Annotation_IDs:CG11909-PA,GB_protein:AAF56462.1,REFSEQ:NP_651391,GB_protein:AAF56462; MD5=3b907107be8cba781b3fc3ab13083fdb; length=657; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:complement(21170578..21170777,21170835..21172608); ID=FBpp0084221; name=CG11909-PA; parent=FBgn0039330,FBtr0084847; dbxref=FlyBase:FBpp0084221,FlyBase_Annotation_IDs:CG11909-PA,GB_protein:AAF56462.1,REFSEQ:NP_651391,GB_protein:AAF56462; MD5=3b907107be8cba781b3fc3ab13083fdb; length=657; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • CG11909 OS=Drosophila melanogaster GN=tobi PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=3R:complement(21170578..21170777,21170835..21172608); ID=FBpp0084221; name=tobi-PA; parent=FBgn0261575,FBtr0084847; dbxref=FlyBase:FBpp0084221,FlyBase_Annotation_IDs:CG11909-PA,GB_protein:AAF56462.1,REFSEQ:NP_651391,GB_protein:AAF56462,FlyMine:FBpp0084221,modMine:FBpp0084221; MD5=3b907107be8cba781b3fc3ab13083fdb; length=657; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3R:complement(join(25345113..25346886,25344856..25345055)); ID=FBpp0084221; name=tobi-PA; parent=FBgn0261575,FBtr0084847; dbxref=FlyBase:FBpp0084221,FlyBase_Annotation_IDs:CG11909-PA,GB_protein:AAF56462.1,REFSEQ:NP_651391,GB_protein:AAF56462,FlyMine:FBpp0084221,modMine:FBpp0084221; MD5=3b907107be8cba781b3fc3ab13083fdb; length=657; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:complement(join(25345113..25346886,25344856..25345055)); ID=FBpp0084221; name=tobi-PA; parent=FBgn0261575,FBtr0084847; dbxref=FlyBase:FBpp0084221,FlyBase_Annotation_IDs:CG11909-PA,GB_protein:AAF56462.1,REFSEQ:NP_651391,GB_protein:AAF56462,FlyMine:FBpp0084221,modMine:FBpp0084221; MD5=3b907107be8cba781b3fc3ab13083fdb; length=657; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • RE74917p OS=Drosophila melanogaster GN=tobi PE=2 SV=1 [DROME.fasta.20160308]
  • FBpp0084221 type=protein; loc=3R:complement(join(25345113..25346886,25344856..25345055)); ID=FBpp0084221; name=tobi-PA; parent=FBgn0261575,FBtr0084847; dbxref=FlyBase:FBpp0084221,FlyBase_Annotation_IDs:CG11909-PA,GB_protein:AAF56462.1,REFSEQ:NP_651391,GB_protein:AAF56462,FlyMine:FBpp0084221,modMine:FBpp0084221; MD5=3b907107be8cba781b3fc3ab13083fdb; length=657; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:complement(join(25345113..25346886,25344856..25345055)); ID=FBpp0084221; name=tobi-PA; parent=FBgn0261575,FBtr0084847; dbxref=FlyBase:FBpp0084221,FlyBase_Annotation_IDs:CG11909-PA,GB_protein:AAF56462.1,REFSEQ:NP_651391,GB_protein:AAF56462,UniProt/TrEMBL:Q9VBR6,FlyMine:FBpp0084221,modMine:FBpp0084221; MD5=3b907107be8cba781b3fc3ab13083fdb; length=657; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 657 amino acids

    Gene Ontology:
    Cellular Component: alpha-glucosidase II complex [ISS]
    Biological Process: carbohydrate metabolic process [IEA]
    Molecular Function: alpha-glucosidase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRFILLSLLL ASFCLWEAVH TCASIEQRYK FPNSNVYVRL RRGDKLQYEL MKGEKSLQTV  60
   61 TFDNFDSSAN LVETSSGSYQ LTDGQSTVEF TLVKSGVVAG TGSEITHVKV SRDQVLQGTQ 120
  121 PRDCVPLKTG STHWFSGPEQ KQHYWPVERQ RHSNYSYLPK ELDNFGVGER YWLNGDGVFL 180
  181 YVESNTPLFI DQNSAAYPDQ LCLSAISALP YDPRVTSAKF VYHVAVAKDA KAAHRYAVKT 240
  241 FLGQPTGYPD ERMVMHPVWS TWALYKAEVS DDVVRDFAKQ ILDNGFNNSQ LEIDDDWEDC 300
  301 YGAMTFRKNK FPDSKTLTDD LKALGFRVTL WIHPFINNNC TAIYDEAKSK GYLVLDHEGS 360
  361 SDTQWWNSKP KDAAILDFTK TEVQEWFSKR LKRLQDEDGI DSFKFDAGET SWLPSDPVLQ 420
  421 ASSSMVTPLQ AVGDYVRTVA AFGDMVEVRS AQNTQDQPIF VRIVDKDSEW GWNNGLLTLI 480
  481 SSMLQMNLNG YPFVLPDMIG GNGYYEKPPT KELFLRWLQA NVFMPALQFS FVPWNFDDEA 540
  541 IAISKNFTAL HATYTPYIMK LFKRAVDSGE PVNVPLWWIA PTDEVAQSIY DEFLLGEDII 600
  601 AAPVVVEGAT KRDIYLPEGE WQDGNSDQVY TGPTWVMDYA APLDTLPYFL RVGFTLE

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..657] PSI-BLAST 101.0 Crystal Structure of Alpha-Xylosidase from Escherichia coli

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • glucosidase activity
    		•  3.36236519085847 bayes_pls_golite062009
  • alpha-glucosidase activity
    		•  2.3919781440515 bayes_pls_golite062009
  • hydrolase activity, hydrolyzing O-glycosyl compounds
    		•  1.98403928115322 bayes_pls_golite062009
  • hydrolase activity, acting on glycosyl bonds
    		•  1.98114731783916 bayes_pls_golite062009
  • hydrolase activity
    		•  1.3322356610484 bayes_pls_golite062009
  • catalytic activity
    		•  0.95519213931595 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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