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Protein Overview: Osbp-PA

General Information:
Name(s) found: Osbp-PA / FBpp0084176 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene Oxysterol binding protein is referred to in FlyBase by the symbol Dmel\Osbp (CG6708, FBgn0020626). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:20760591..20763959. It has the cytological map location 96B10. Based on sequence similarity, it is predicted to have molecular function</span>: oxysterol binding. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: steroid metabolic process. 5 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 784 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: steroid metabolic process [IEA]
    Molecular Function: oxysterol binding [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTDAAGNALA EKGLPEMKGW LLKWTNYIKG YQRRWFVLSK GVLSYYRNQS EINHTCRGTI  60
   61 SLHGALIHTV DSCTFVISNG GTQTFHIKAG TEVERQSWVT ALELAKAKAI RAIECEEEEE 120
  121 TETAHVVPSQ EISSVVRDLT DRLESMRTCY DLITKHGAAL QRALNDLETN EEESLGSRTK 180
  181 IVNERATLFR ITSNAMINAG NDYLHTAEAQ GHKWSKMLHH EREQRQRLEE IIEQMAKQQS 240
  241 QMEQAAVLVR QNKPVSSTSG AGTAGSLVTS DEEMEFFDAE EHGYSGSGRS PESSDCERGT 300
  301 FILKMHKRRS SSEDQVEGHL EGSSSESDEQ KRTVQTVQQV CLVSAPRVAS GGQGDDDDDV 360
  361 DKALPAKEST DSIYGRNWNP DLIKKRRDRV PDKPNHPISL WGIMKNCIGK DLSKIPMPIN 420
  421 FNEPLSMLQR LVEDYEYTEI LDYAATCQDE CEQLAYIAAF TVSAYATTTN RTGKPFNPLL 480
  481 GETYECDRMD DYGWRCLAEQ VSHHPPVAAL HCESKNWTCW QEFSMTSKFR GKYVQINPLG 540
  541 GVYVQFPNSG RRYSWRKVTT TVNNIIVGKL WVDQHGEMEI RGSQAAEGHK CILNFIPYSY 600
  601 FSRDVQRSVK GVVMNKDNEV KWVVRGTWDM KIEIAPVLKT SGSVSSPTYT TGEFKLAWRR 660
  661 RPAPPDSDKF YNFTTLACQL NEEEEGVAPT DSRLRPDQRL MEQGDWDESN KEKLRLEEKQ 720
  721 RTERRRRENE AEEAAAEGRP YPAYEPMWFK REKEEGSEEY VHVFKNTYWE AKAAQNFEGC 780
  781 PDIY

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..150] PSI-BLAST 18.69897 Tapp1
    2 View Details [151..386] deduced N/A No confident structure predictions are available.
    3 View Details [387..784] PSI-BLAST 61.154902 Structure of yeast oxysterol binding protein Osh4 in complex with 7-hydroxycholesterol

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.71153495886736 bayes_pls_golite062009
  • protein binding
    		•  1.18328783605179 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • sterol binding
    		•  3.12877992228795 bayes_pls_golite062009
  • steroid binding
    		•  2.54679035876403 bayes_pls_golite062009
  • lipid binding
    		•  1.46539100663772 bayes_pls_golite062009
  • oxysterol binding
    		•  1.1738554488982 bayes_pls_golite062009
  • binding
    		•  0.958372296392311 bayes_pls_golite062009
  • phospholipid binding
    		•  0.0867097353003303 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle