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View Structure Prediction Details

Protein: Osbp-PA
Organism: Drosophila melanogaster
Length: 784 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for Osbp-PA.

Description E-value Query
Range
Subject
Range
gi|54638219|gb|E... - GA19801-PA [Drosophila pseudoobscura], GA19801 [Drosophila pseudoobscura pseudoobscura]
gi|54638219, gi|... - gi|54638219|gb|EAL27621.1| GA19801 [Drosophila pseudoobscura pseudoobscura], gi|125774447|ref|XP_001...
583.0 [0..1] [784..1]

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Predicted Domain #1
Region A:
Residues: [1-150]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTDAAGNALA EKGLPEMKGW LLKWTNYIKG YQRRWFVLSK GVLSYYRNQS EINHTCRGTI  60
   61 SLHGALIHTV DSCTFVISNG GTQTFHIKAG TEVERQSWVT ALELAKAKAI RAIECEEEEE 120
  121 TETAHVVPSQ EISSVVRDLT DRLESMRTCY 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 18.69897
Match: 1eazA
Description: Tapp1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 1.71153495886736 bayes_pls_golite062009
protein binding 1.18328783605179 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [151-386]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DLITKHGAAL QRALNDLETN EEESLGSRTK IVNERATLFR ITSNAMINAG NDYLHTAEAQ  60
   61 GHKWSKMLHH EREQRQRLEE IIEQMAKQQS QMEQAAVLVR QNKPVSSTSG AGTAGSLVTS 120
  121 DEEMEFFDAE EHGYSGSGRS PESSDCERGT FILKMHKRRS SSEDQVEGHL EGSSSESDEQ 180
  181 KRTVQTVQQV CLVSAPRVAS GGQGDDDDDV DKALPAKEST DSIYGRNWNP DLIKKR

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [387-784]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RDRVPDKPNH PISLWGIMKN CIGKDLSKIP MPINFNEPLS MLQRLVEDYE YTEILDYAAT  60
   61 CQDECEQLAY IAAFTVSAYA TTTNRTGKPF NPLLGETYEC DRMDDYGWRC LAEQVSHHPP 120
  121 VAALHCESKN WTCWQEFSMT SKFRGKYVQI NPLGGVYVQF PNSGRRYSWR KVTTTVNNII 180
  181 VGKLWVDQHG EMEIRGSQAA EGHKCILNFI PYSYFSRDVQ RSVKGVVMNK DNEVKWVVRG 240
  241 TWDMKIEIAP VLKTSGSVSS PTYTTGEFKL AWRRRPAPPD SDKFYNFTTL ACQLNEEEEG 300
  301 VAPTDSRLRP DQRLMEQGDW DESNKEKLRL EEKQRTERRR RENEAEEAAA EGRPYPAYEP 360
  361 MWFKREKEEG SEEYVHVFKN TYWEAKAAQN FEGCPDIY

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 61.154902
Match: 1zhtA
Description: Structure of yeast oxysterol binding protein Osh4 in complex with 7-hydroxycholesterol
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
sterol binding 3.12877992228795 bayes_pls_golite062009
steroid binding 2.54679035876403 bayes_pls_golite062009
lipid binding 1.46539100663772 bayes_pls_golite062009
oxysterol binding 1.1738554488982 bayes_pls_golite062009
binding 0.958372296392311 bayes_pls_golite062009
phospholipid binding 0.0867097353003303 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle