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Protein Overview: eIF4G2-PA, FBpp0...

General Information:
Name(s) found: FBpp0310717 [FlyBase]
eIF4G2-PA / FBpp0088566 [FlyBase]
Description(s) found:
Found 25 descriptions.
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  • type=protein; loc=3R:complement(19636016..19638307,19638422..19639536,19639735..19640637,19640691..19640828,19640963..19642733); ID=FBpp0310717; name=eIF4G2-PC; parent=FBgn0260634,FBtr0344335; dbxref=FlyBase:FBpp0310717,FlyBase_Annotation_IDs:CG10192-PC; MD5=6388249d541e8b25e6e492c1746c38f5; length=2072; release=r5.56; species=Dmel; [FlyBase]
  • The gene eukaryotic translation initiation factor 4G2 is referred to in FlyBase by the symbol Dmel\eIF4G2 (CG10192, FBgn0260634). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:19635550..19644364. It has the cytological map location 95B9-95C1. There is experimental evidence that it has the molecular function</span>: RNA 7-methylguanosine cap binding. There is experimental evidence that it is involved in the biological process</span>: spermatid differentiation; G1/S transition of mitotic cell cycle; meiotic G2/MI transition; male meiosis; autophagic cell death; salivary gland cell autophagic cell death; spermatogenesis. 10 alleles are reported. The phenotypes of these alleles are annotated with: spermatid; testis; spermatocyte; spermatozoon. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 2072 amino acids

    Gene Ontology:
    Cellular Component: eukaryotic translation initiation factor 4F complex [ISS]
    Biological Process: RNA metabolic process [IEA]
    autophagic cell death [IEP]
    spermatogenesis [IMP]
    male meiosis [IMP]
    G1/S transition of mitotic cell cycle [IGI]
    spermatid differentiation [IMP]
    salivary gland cell autophagic cell death [IEP]
    translational initiation [ISS]
    meiotic G2/MI transition [IMP]
    Molecular Function: translation initiation factor activity [ISS]
    RNA 7-methylguanosine cap binding [IDA]
    protein binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFPQQGGGGK GTRPQSTHQQ NHNHQAQHHQ ATHSHHHHLQ QQQEQQQSHA VFVPNHSGLH  60
   61 HHQQQHLLQQ QQQQHQQQAA VAAAHLQQHI QQQQQQQVQA QAQAHHQPVI FYNTQPSYAA 120
  121 HSAAVNNSAN GGGATLQLSA AASSNTLGHP LTGGHHGGAN GVAPGSNMPR ALSNPTLPPH 180
  181 FQQSAGLIAP AGGNAGGPYI SATYIPINQT GPLMGMQPAV TFPTNGAAGA SFYAAAPPPP 240
  241 QQKQLPPTAQ QQGPGGAPGA AQTPTLAYYQ LGPNAQNSAG NNVVSGANTH RGNMRGGQRS 300
  301 TPTAQHTNYF TAYTMAPGNA QRPAPTNVAP MMNSRSGALN GAAAFHHLPH NFGIPSLALG 360
  361 PPAGMTTPIL APAGMQAPPP QPPGGLHTFA PHLQSNSATT LPSVPSVTGV PAVASGFSTT 420
  421 SLPTPSVTTA PQLGANSDKV CKRKYAIPII HPDTMENVMD GWKRSVFIKK DSNSTLTQHT 480
  481 DLDTALDDNS TLCLYQAPTL MDSGSGSSLL SGAMVDQQMQ TVKPASSLKQ SVSLEKVPEA 540
  541 VYCKDAVGQD VHPSPPPKST DKDQISVIVK DILAHSGNAE DHLSFWQYSD VDNVTETHNS 600
  601 LPLVQSDLPD TTDTCQQPVL FQEQAKKQRP KLANKQSTAT PASIANDVAE AAASGCPGVS 660
  661 ILSRGQSMVT PAGPSTPPPP SRVAQQKSTK SIVTTAVAAS VKPTTGSPNR KSSIQAATST 720
  721 TTSSGASSST ASTPTHASSK LKQQPVNNLQ HGKQIPGKVS TPALPPTASR ISAAVTLLAG 780
  781 TANITTTTNS SKKQRQAQKR ARELEKKKQK SSITSTTSTQ GQNNNGKGNG NGNAALEINT 840
  841 NSNNAATVTT TSMSTLTTTT TATAPTTKQE TAAVDDKETA QPTTDTLSAT SNNTKVSSIL 900
  901 RDKKTMLNPK EQLTSHNNNN NNNNEDGIEA KVESDPESDI KDDSMSNITG EKSEKHLANE 960
  961 EIVAKFLQKD SPDTSVVHAE TQQLQFLNSS SSVCEEDEPV PVISEGVTKT EENAEAEIKF1020
 1021 GDFHEDPRND TGFICSSTWS SSTISKAAED DSSQSSRSAD NVDCAPKVVE QISEEKSASS1080
 1081 TKSSPVHKAT GSGPGSPKTK ELKSKSPSPI PVPQVPKNYR YSIETLRELA KRRDSRKPPM1140
 1141 VPCQKGDCIS QLFVSRQQQP QQHHGQHIQQ YQHMSFNESL DYVPGKRGRG HGPNKKHHDQ1200
 1201 HQQMGGSSGM GSGSGGGGGI SNSSQRHMDI IRVQLSLKEE IKLSECENAW QPGTLRRVSM1260
 1261 AGGQDEDDDV EGVLKKVRGI LNKLTPDNFE VLLKEMSSIK MDNEAKMTNV MLLIFEKTIS1320
 1321 EPNFAPTYAR FCKVLFHEIK AENKSLFTSS LITRIQHEFE SNVNDANAKS KKLQPTMERI1380
 1381 NQCSDPAKKA ELRAEMEDLE YQFRRRAWGT VRFIGELFKL QSLTNDRVLN CVESLLEHGC1440
 1441 EEKLEYMCKL LTTVGHLLES SLPEHYQLRD RIEKIFRRIQ DIINRSRGTS HRQQVHIKIS1500
 1501 SRVRFMMQDV LDLRLRNWDQ PATHQSGQQG GRGQRHKQHD DSKDQSHSTG GGRGGGMNQH1560
 1561 QQSSTHHQHQ KHNQHGHDGG NYFMQKMPNK QHHENQTLSI DPSKLRFSNS SATDDSIAKL1620
 1621 GNSSHYQWRN VGNRPVSSTQ VNASNAPPPT SLLKRPGQNY KFLPYQQPSA VAGTANAPAG1680
 1681 GNKSNVEVND AFDGKQCQGL ITKLVEEALN TREWQPEVLS IWRSHSGSQQ SKTLFHLLTD1740
 1741 YLHKSTVKRQ HRQACGNIFA YLMDKDAVEK EIFEEAYSRF GDDFPDLLVD VPNGWGYVFE1800
 1801 FLGPIIHSGH LDLKDVWQRR WLDDFFFAER FVYAFVSYFV QEFGAAYARK LWHNDYKLDR1860
 1861 GQLFWSDVRK YREFVQSHSF YFLDNGPGQN QGHAKVKAPT TPRSPVEHVE RIRHLLAISC1920
 1921 DMAIDYINTN VAINDKFVRQ LTRFLCCDFA LTVMTNTHNN IKSGGNSKPL QLNTESFRSC1980
 1981 CTPLLRLCID AQEALEIACI DEAVDALQQH FMTEYEDDMA AGETICSTFS VLYESEVIPK2040
 2041 ESFDKWYKLE MAHSRAYRRP FIDKLRGFIE EM

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..238] MSA 2.279996 View MSA. No confident structure predictions are available.
    2 View Details [239..409] MSA 2.301988 View MSA. No confident structure predictions are available.
    3 View Details [410..506] deduced N/A No confident structure predictions are available.
    4 View Details [507..688] MSA 2.296989 View MSA. No confident structure predictions are available.
    5 View Details [689..895] deduced N/A No confident structure predictions are available.
    6 View Details [896..1117] deduced N/A No confident structure predictions are available.
    7 View Details [1118..1263] deduced N/A No confident structure predictions are available.
    8 View Details [1264..1588] PSI-BLAST 111.0 Eukaryotic initiation factor eIF4G
    9 View Details [1589..1689] deduced N/A No confident structure predictions are available.
    10 View Details [1690..2072] PSI-BLAST 121.0 C-terminal portion of human eIF4GI

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.
    6 No functions predicted.
    7 No functions predicted.
    8
    Term Confidence Notes
  • binding
    		•  0.373576425899935 bayes_pls_golite062009
    9 No functions predicted.
    10 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.88

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle