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Protein Overview: Irk2-PB

General Information:
Name(s) found: Irk2-PB / FBpp0083818 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene Inwardly rectifying potassium channel 2 is referred to in FlyBase by the symbol Dmel\Irk2 (CG4370, FBgn0039081). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:19339690..19345167. It has the cytological map location 95A1. There is experimental evidence that it has the molecular function</span>: inward rectifier potassium channel activity. There is experimental evidence that it is involved in the biological process</span>: potassium ion transport; regulation of membrane potential. 4 alleles are reported. No phenotypic data is available. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 437 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [IDA]
    Biological Process: potassium ion transport [IDA]
    regulation of membrane potential [IDA]
    Molecular Function: G-protein activated inward rectifier potassium channel activity [ISS]
    inward rectifier potassium channel activity [IDA][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQVPLSDVQV LQDPTDAETL VGGDKEETFA HMKEWKRQYM RGISHTPSQA GVYYEALKGS  60
   61 SHSLAKGSRN FRPGSMRRVR RRAVFKNGDC NVVQKHLQRR RVRFLQDMYT TMVDWQWRWT 120
  121 LLAFALSFIL SWLFFALIWW LIIYTHGDLE EPHLPENQEE SGWAPCVSAI DGFTSCFLFS 180
  181 IETQHTIGYG VRTTSPECPE AIFMMCFQSI YGVMSSAFMA GIVFAKMTRA KQRAQTLLFS 240
  241 KHAVICQRDG TLSLMFRVGD MRKSHIIGAG VRAQLIRTKS TKEGEVMTQY FTELEIGTDD 300
  301 SGSDLFFIWP MVIEHKIDEN SPLYNLNATD MLQDKFEIVV ILEGTVESTG QSTQARSSYI 360
  361 NTEILWGHRF DPVVLYNKDL QAYEIDYARF NETTQVDTPL CSARELNEIY KIQEGFRTPE 420
  421 TTFTMRQLSH NHSDQAS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..437] PSI-BLAST 86.0 No description for 2qksA was found.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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