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Protein Overview: SKIP-PB

General Information:
Name(s) found: SKIP-PB / FBpp0083595 [FlyBase]
Description(s) found:
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  • gi|28571813|ref|NP_788712.1| CG31163-PC, isoform C [Drosophila melanogaster] [NCBI NR]
  • gi|28381413|gb|AAO41587.1| CG31163-PC, isoform C [Drosophila melanogaster] [NCBI NR]
  • gi|28317117|gb|AAO39577.1| LD40351p [Drosophila melanogaster] [NCBI NR]
  • gi|24648917|ref|NP_732703.1| CG31163, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|23176032|gb|AAF55958.2| CG31163, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|17944264|gb|AAL48026.1| LD31046p [Drosophila melanogaster] [NCBI NR]
  • The gene Shal K<sup>+</sup> channel interacting protein is referred to in FlyBase by the symbol Dmel\SKIP (CG31163, FBgn0051163). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:17959580..18121057. It has the cytological map location 94A2-94A4. Based on sequence similarity, it is predicted to have molecular function</span>: SH3/SH2 adaptor activity. The biological processes in which it is involved are not known. 31 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • >CG31163-PB translation from_gene[CG31163 CG31163 FBgn0051163] seq_release:3 mol_weight=103326 cds_boundaries:(3R:17,991,054..18,110,584[+]) aa_length:952 transcript_info:[CG31163-RB seq_release:3] gene_info:[gene symbol:CG31163 synonyms:[CG13864 CG138 [hmr_yeast5_DM3-1_pombe.fasta]
  • >CG31163-PC translation from_gene[CG31163 CG31163 FBgn0051163] seq_release:3 mol_weight=103326 cds_boundaries:(3R:17,991,054..18,110,584[+]) aa_length:952 transcript_info:[CG31163-RC seq_release:3] gene_info:[gene symbol:CG31163 synonyms:[CG13864 CG138 [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q8SZS0) LD31046p (CG31163-PB) (LD40351p) [DrosMelano7227.FASTAC.txt]
  • CG31163-PC, isoform C [Drosophila melanogaster]gi|23176032|gb|AAF55958.2| CG31163-PB, isoform B [Drosophila melanogaster]gi|28317117|gb|AAO39577.1| LD40351p [Drosophila melanogaster]gi|17944264|gb|AAL48026.1| LD31046p [Drosophila melanogaster]gi|28571 [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:join(18000090..18000449,18104074..18104348,18104428..18104477,18104951..18105057,18106521..18106607,18107569..18107625,18110600..18110657,18111194..18111423,18113519..18113682,18115202..18115283,18115800..18116018,18116884..18117076,1 [fly-100309-contam.fasta]
  • CG31163-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • LD40351p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • LD31046p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3R:join(18000090..18000449,18104074..18104348,18104428..18104477,18104951..18105057,18106521..18106607,18107569..18107625,18110600..18110657,18111194..18111423,18113519..18113682,18115202..18115283,18115800..18116018,18116884..18117076,18118035..18118180,18118335..18118600,18118672..18118793,18119181..18119623); ID=FBpp0083595; name=CG31163-PB; parent=FBgn0051163,FBtr0084197; dbxref=FlyBase:FBpp0083595,FlyBase_Annotation_IDs:CG31163-PB,GB_protein:AAF55958.2,REFSEQ:NP_732703,GB_protein:AAF55958; MD5=fab6dd0ff4e3fb79efd91beabeb73747; length=952; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:join(18000090..18000449,18104074..18104348,18104428..18104477,18104951..18105057,18106521..18106607,18107569..18107625,18110600..18110657,18111194..18111423,18113519..18113682,18115202..18115283,18115800..18116018,18116884..18117076,18118035..18118180,18118335..18118600,18118672..18118793,18119181..18119623); ID=FBpp0083595; name=CG31163-PB; parent=FBgn0051163,FBtr0084197; dbxref=FlyBase:FBpp0083595,FlyBase_Annotation_IDs:CG31163-PB,GB_protein:AAF55958.2,REFSEQ:NP_732703,GB_protein:AAF55958; MD5=fab6dd0ff4e3fb79efd91beabeb73747; length=952; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • CG31163, isoform B OS=Drosophila melanogaster GN=SKIP PE=1 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=3R:join(18000090..18000449,18104074..18104348,18104428..18104477,18104951..18105057,18106521..18106607,18107569..18107625,18110600..18110657,18111194..18111423,18113519..18113682,18115202..18115283,18115800..18116018,18116884..18117076,18118035..18118180,18118335..18118600,18118672..18118793,18119181..18119623); ID=FBpp0083595; name=SKIP-PB; parent=FBgn0051163,FBtr0084197; dbxref=FlyBase:FBpp0083595,FlyBase_Annotation_IDs:CG31163-PB,GB_protein:AAF55958.2,REFSEQ:NP_732703,GB_protein:AAF55958,FlyMine:FBpp0083595,modMine:FBpp0083595; MD5=fab6dd0ff4e3fb79efd91beabeb73747; length=952; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • CG31163, isoform B OS=Drosophila melanogaster GN=SKIP PE=2 SV=1 [UniProt_D_Melanogaster_07132012_07-13-2012_reversed.fasta]
  • type=protein; loc=3R:join(22174368..22174727,22278352..22278626,22278706..22278755,22279229..22279335,22280799..22280885,22281847..22281903,22284878..22284935,22285472..22285701,22287797..22287960,22289480..22289561,22290078..22290296,22291162..22291354,22292313..22292458,22292613..22292878,22292950..22293071,22293459..22293901); ID=FBpp0083595; name=SKIP-PB; parent=FBgn0051163,FBtr0084197; dbxref=FlyBase:FBpp0083595,FlyBase_Annotation_IDs:CG31163-PB,GB_protein:AAF55958.2,REFSEQ:NP_732703,GB_protein:AAF55958,FlyMine:FBpp0083595,modMine:FBpp0083595; MD5=fab6dd0ff4e3fb79efd91beabeb73747; length=952; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:join(22174368..22174727,22278352..22278626,22278706..22278755,22279229..22279335,22280799..22280885,22281847..22281903,22284878..22284935,22285472..22285701,22287797..22287960,22289480..22289561,22290078..22290296,22291162..22291354,22292313..22292458,22292613..22292878,22292950..22293071,22293459..22293901); ID=FBpp0083595; name=SKIP-PB; parent=FBgn0051163,FBtr0084197; dbxref=FlyBase:FBpp0083595,FlyBase_Annotation_IDs:CG31163-PB,GB_protein:AAF55958.2,REFSEQ:NP_732703,GB_protein:AAF55958,FlyMine:FBpp0083595,modMine:FBpp0083595; MD5=fab6dd0ff4e3fb79efd91beabeb73747; length=952; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of A0A0B4KHV7, LD31046p OS=Drosophila melanogaster GN=SKIP PE=2 SV=1 [DROME.fasta.20160308]
  • FBpp0083595 type=protein; loc=3R:join(22174368..22174727,22278352..22278626,22278706..22278755,22279229..22279335,22280799..22280885,22281847..22281903,22284878..22284935,22285472..22285701,22287797..22287960,22289480..22289561,22290078..22290296,22291162..22291354,22292313..22292458,22292613..22292878,22292950..22293071,22293459..22293901); ID=FBpp0083595; name=SKIP-PB; parent=FBgn0051163,FBtr0084197; dbxref=FlyBase:FBpp0083595,FlyBase_Annotation_IDs:CG31163-PB,GB_protein:AAF55958.2,REFSEQ:NP_732703,GB_protein:AAF55958,FlyMine:FBpp0083595,modMine:FBpp0083595; MD5=fab6dd0ff4e3fb79efd91beabeb73747; length=952; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:join(22174368..22174727,22278352..22278626,22278706..22278755,22279229..22279335,22280799..22280885,22281847..22281903,22284878..22284935,22285472..22285701,22287797..22287960,22289480..22289561,22290078..22290296,22291162..22291354,22292313..22292458,22292613..22292878,22292950..22293071,22293459..22293901); ID=FBpp0083595; name=SKIP-PB; parent=FBgn0051163,FBtr0084197; dbxref=FlyBase:FBpp0083595,FlyBase_Annotation_IDs:CG31163-PB,GB_protein:AAF55958.2,REFSEQ:NP_732703,GB_protein:AAF55958,UniProt/TrEMBL:Q8SZS0,FlyMine:FBpp0083595,modMine:FBpp0083595; MD5=fab6dd0ff4e3fb79efd91beabeb73747; length=952; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 952 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: NONE FOUND
    Molecular Function: SH3/SH2 adaptor activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVSNIVCEW LRALGLAQYA ESFLDNGYDD LEICKQVGDP DLDAIGVENP AHRHKLLKSI  60
   61 RSLREKGAAS VYFMLNDPNS LSGSMEILCE TPPNNELELV LREQLETDGV RLTAHPYSTP 120
  121 PSSCLSDKEE DEIYGFGYGV FAPRVARGGL TQQQQLLQQQ TLQTQQSIQQ QQQQMQQQQQ 180
  181 QLPIVPGQQQ QGPHQHQTLP PNVAHLNFVQ QNCLSPRSAY FYEFPPTAEG RETKKRTTLA 240
  241 RLLKGLKTVN RRDRNNQQNG AQARAANDRL RHFQMINGGA GGQQHSFEET IHRLKVQEAM 300
  301 RKKEKFQREH EEILRDIRQG LLQMSRGEGR MDDTYMYDEA LRTGGGMGIA GLGMPLGVGG 360
  361 NGGGGGAAHY AVSALHHQGH WYDEPPYESD PDDFLMAGLN CGPAATIQGG RVRFSNNRES 420
  421 TGVISLRSAG DISLPQRGPP RRGLIVPQQP PNPPTIIPLT HARSHDRESG DYAGSISDLQ 480
  481 SVTSRFSTVS IGTNNCTARY RTLSGGIGES PSLSPSPSSD YEDIGVTRGH GCLPPSLLAA 540
  541 KAKKNGLPHG KANTICQKAT VHHSGEMRSS AKEIGAFNEN GRNFVATKDT SRDFSNSQDN 600
  601 TDRGSMSDQA FACSASSVES LPSASGSSTQ ALVRPGSPHS SISAEDRTSM ASCICKAKAL 660
  661 VDSLPNPYDK EALKFKKGDL IDVLSMNASG IWKGRCHGRV GHFKFINVEV LPEQRMKNSS 720
  721 SKTLAAGSRL ANSGNGSHNG GPCSVEDLLI RIGLKEYTSV FVLNGYEDLE LFKELEPADL 780
  781 DYLGILNQEH RAKLLTAVQL LHDIECSDVD IPGSSSENDE ARLNNINMKH GASPFGRRHF 840
  841 PRDSGCYEGS PLPSSQTPTQ AVNSTDESNS LDDVVTKCSS EIMKRVESAR RCKDNPFKTT 900
  901 LPGGGRLGKK SFLGGNGLMA DDTLTRGGLS EKSSDSGVSS SSLSSGPLKS ST

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..123] PSI-BLAST 19.69897 No description for 2eaoA was found.
    2 View Details [124..309] MSA 1.093991 View MSA. No confident structure predictions are available.
    3 View Details [310..384] deduced N/A No confident structure predictions are available.
    4 View Details [385..711] PSI-BLAST 20.522879 No description for 2eyzA was found.
    5 View Details [712..952] PSI-BLAST 17.221849 beta-pix

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5
    Term Confidence Notes
  • enzyme regulator activity
    		•  0.49904976298923 bayes_pls_golite062009
  • nucleoside-triphosphatase regulator activity
    		•  0.46369712748634 bayes_pls_golite062009
  • GTPase regulator activity
    		•  0.46355856898498 bayes_pls_golite062009
  • guanyl-nucleotide exchange factor activity
    		•  0.43111420227783 bayes_pls_golite062009
  • binding
    		•  0.0359693154751609 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.93

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle