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View Structure Prediction Details

Protein: SKIP-PB
Organism: Drosophila melanogaster
Length: 952 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SKIP-PB.

Description E-value Query
Range
Subject
Range
gi|116008070, gi... - gi|116008070|ref|NP_001036742.1| CG31163, isoform D [Drosophila melanogaster], gi|113194815|gb|ABI31...
632.0 [0..103] [931..207]

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Predicted Domain #1
Region A:
Residues: [1-123]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVSNIVCEW LRALGLAQYA ESFLDNGYDD LEICKQVGDP DLDAIGVENP AHRHKLLKSI  60
   61 RSLREKGAAS VYFMLNDPNS LSGSMEILCE TPPNNELELV LREQLETDGV RLTAHPYSTP 120
  121 PSS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 19.69897
Match: 2eaoA
Description: No description for 2eaoA was found.

Predicted Domain #2
Region A:
Residues: [124-309]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CLSDKEEDEI YGFGYGVFAP RVARGGLTQQ QQLLQQQTLQ TQQSIQQQQQ QMQQQQQQLP  60
   61 IVPGQQQQGP HQHQTLPPNV AHLNFVQQNC LSPRSAYFYE FPPTAEGRET KKRTTLARLL 120
  121 KGLKTVNRRD RNNQQNGAQA RAANDRLRHF QMINGGAGGQ QHSFEETIHR LKVQEAMRKK 180
  181 EKFQRE

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [310-384]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HEEILRDIRQ GLLQMSRGEG RMDDTYMYDE ALRTGGGMGI AGLGMPLGVG GNGGGGGAAH  60
   61 YAVSALHHQG HWYDE

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [385-711]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPYESDPDDF LMAGLNCGPA ATIQGGRVRF SNNRESTGVI SLRSAGDISL PQRGPPRRGL  60
   61 IVPQQPPNPP TIIPLTHARS HDRESGDYAG SISDLQSVTS RFSTVSIGTN NCTARYRTLS 120
  121 GGIGESPSLS PSPSSDYEDI GVTRGHGCLP PSLLAAKAKK NGLPHGKANT ICQKATVHHS 180
  181 GEMRSSAKEI GAFNENGRNF VATKDTSRDF SNSQDNTDRG SMSDQAFACS ASSVESLPSA 240
  241 SGSSTQALVR PGSPHSSISA EDRTSMASCI CKAKALVDSL PNPYDKEALK FKKGDLIDVL 300
  301 SMNASGIWKG RCHGRVGHFK FINVEVL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 20.522879
Match: 2eyzA
Description: No description for 2eyzA was found.

Predicted Domain #5
Region A:
Residues: [712-952]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PEQRMKNSSS KTLAAGSRLA NSGNGSHNGG PCSVEDLLIR IGLKEYTSVF VLNGYEDLEL  60
   61 FKELEPADLD YLGILNQEHR AKLLTAVQLL HDIECSDVDI PGSSSENDEA RLNNINMKHG 120
  121 ASPFGRRHFP RDSGCYEGSP LPSSQTPTQA VNSTDESNSL DDVVTKCSSE IMKRVESARR 180
  181 CKDNPFKTTL PGGGRLGKKS FLGGNGLMAD DTLTRGGLSE KSSDSGVSSS SLSSGPLKSS 240
  241 T

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 17.221849
Match: 1by1A
Description: beta-pix
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
enzyme regulator activity 0.49904976298923 bayes_pls_golite062009
nucleoside-triphosphatase regulator activity 0.46369712748634 bayes_pls_golite062009
GTPase regulator activity 0.46355856898498 bayes_pls_golite062009
guanyl-nucleotide exchange factor activity 0.43111420227783 bayes_pls_golite062009
binding 0.0359693154751609 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle