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Protein Overview: H-PA, H-PD

General Information:
Name(s) found: H-PD / FBpp0083324 [FlyBase]
H-PA / FBpp0083322 [FlyBase]
Description(s) found:
Found 32 descriptions.
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  • The gene Hairless is referred to in FlyBase by the symbol Dmel\H (CG5460, FBgn0001169). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:16447665..16454637. It has the cytological map location 92F3. There is experimental evidence that it has the molecular function</span>: transcription corepressor activity. There is experimental evidence that it is involved in the biological process</span>: negative regulation of Notch signaling pathway; sensory organ boundary specification; sensory organ precursor cell fate determination; wing disc dorsal/ventral pattern formation. 114 alleles are reported. The phenotypes of these alleles are annotated with 52 unique terms, many of which group under: peripheral nervous system; adult segment; nervous system; adult mesothoracic segment; organ system; external compound sense organ; embryonic nervous system; eo support cell; imaginal precursor; anterior orbital bristle; dorsal thoracic disc; embryonic hindgut; adult cuticle; external sensory organ precursor cell; adult external prothorax; embryonic trachea; late extended germ band embryo; postalar bristle. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
  • The gene Hairless is referred to in FlyBase by the symbol Dmel\H (CG5460, FBgn0001169). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:16447665..16454637. It has the cytological map location 92F3. There is experimental evidence that it has the molecular function</span>: transcription corepressor activity. There is experimental evidence that it is involved in the biological process</span>: negative regulation of Notch signaling pathway; sensory organ boundary specification; sensory organ precursor cell fate determination; wing disc dorsal/ventral pattern formation. 114 alleles are reported. The phenotypes of these alleles are annotated with 52 unique terms, many of which group under: peripheral nervous system; adult segment; nervous system; adult mesothoracic segment; organ system; external compound sense organ; embryonic nervous system; eo support cell; imaginal precursor; anterior orbital bristle; dorsal thoracic disc; embryonic hindgut; adult cuticle; external sensory organ precursor cell; adult external prothorax; embryonic trachea; late extended germ band embryo; postalar bristle. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1077 amino acids

    Gene Ontology:
    Cellular Component: nucleus [NAS][TAS]
    Biological Process: sensory organ boundary specification [IMP]
    Notch signaling pathway [NAS]
    sensory organ precursor cell fate determination [IMP][TAS]
    wing disc dorsal/ventral pattern formation [IMP]
    negative regulation of Notch signaling pathway [IGI][TAS]
    Molecular Function: transcription corepressor activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALLNDVTSV AECNRQTTMT DEHKSNINSN SSHSSNNNNN GSSSNNDNNS NDDAASSSNS  60
   61 KNNNTSNESS HSNNNTSSII AEAAAKFLLK NGLNGSSSTS YPPLPPPLPA NLSRTTTPTT 120
  121 TTTPSSSSST ASNGFLPHAK TPKSSSIMAA SAAVAASVVG ATASKPTIDV LGGVLDYSSL 180
  181 GGAATGSLPT TAVVAAAAGT AKIGKGSNSG GSFDMGRTPI STHGNNSWGG YGGRLQFFKD 240
  241 GKFILELARS KDGDKSGWVS VTRKTFRPPS AATSATVTPT SAVTTAYPKN ENSTSLSFSD 300
  301 DNSSIQSSPW QRDQPWKQSR PRRGISKELS LFFHRPRNST LGRAALRTAA RKRRRPHEPL 360
  361 TTSEDQQPIF ATAIKAENGD DTLKAEAAEA VEIENVAVAD TTTNEIKIEK PDTIKGEDDA 420
  421 ERLEKEPKKA VSDDSESKEA SPGQQVEPQP KDETVDVEMK MNTSEDEEPM TELPRITNAV 480
  481 NGDLNGDLKA SIGKPKSKPK PKAKLSSIIQ KLIDSVPARL EQMSKTSAVI ASTTTSSDRI 540
  541 GGGLSHALTH KVSPPSSATA AGRLVEYHTQ HVSPRKRILR EFEKVSLEDN GCVNNGSGGA 600
  601 SSGGAGGKRS RAKGTSTSSP AGKASPMNLA PPQGKPSPSP GSSSSSTSPA TLSTQPTRLN 660
  661 SSYSIHSLLG GSSGSGSSSF SSSGKKCGDH PAAIISNVHH PQHSMYQPSS SSYPRALLTS 720
  721 PKSPDVSGSN GGGGKSPSHT GTKKRSPPYS AGSPVDYGHS FYRDPYAGAG RPSTSGSASQ 780
  781 DLSPPRSSPA SPATTPRTVP KKTASIRREF ASPSASSSSC PSPGDRSASP PERRHMQQQP 840
  841 HLQRSSPLHY YMYPPPPQVN GNGSAGSPTS APPTSNSSAA AVAAAAAAAA AYIPSPSIYN 900
  901 PYISTLAALR HNPLWMHHYQ TGASPLLSPH PQPGGSAAAA AAAAAARLSP QSAYHAFAYN 960
  961 GVGAAVAAAA AAAAFGQPAP SPHTHPHLAH PHQHPHPAAL TTHHSPAHLA TPKLTDSSTD1020
 1021 QMSATSSHRT ASTSPSSSSA SASSSAATSG ASSSAMFHTS SLRNEQSSDL PLNLSKH

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..298] deduced N/A No confident structure predictions are available.
    2 View Details [299..412] deduced N/A No confident structure predictions are available.
    3 View Details [413..599] deduced N/A No confident structure predictions are available.
    4 View Details [600..762] deduced N/A No confident structure predictions are available.
    5 View Details [763..883] MSA 2.130978 View MSA. No confident structure predictions are available.
    6 View Details [884..1077] MSA 1.114978 View MSA. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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