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Protein Overview: WRNexo-PA

General Information:
Name(s) found: WRNexo-PA / FBpp0083007 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene WRN exonuclease is referred to in FlyBase by the symbol Dmel\WRNexo (CG7670, FBgn0038608). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:14189966..14191898. It has the cytological map location 91A3. Based on sequence similarity, it is predicted to have molecular function</span>: 3'-5' exonuclease activity. There is experimental evidence that it is involved in the biological process</span>: negative regulation of mitotic recombination. 3 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 353 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEA]
    Biological Process: DNA catabolic process, exonucleolytic [IC]
    negative regulation of mitotic recombination [IMP]
    nucleobase, nucleoside, nucleotide and nucleic acid metabolic process [IEA]
    Molecular Function: nucleic acid binding [IEA]
    3'-5' exonuclease activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEKYLTKMPI KSKANEVPKE EAGVKKETPK VARKATKKDT PKELKDKENA GDDNTPKQTK  60
   61 GRPGRPAAKR KNLDTPDVTE KLAMEEENPP KRRSSRLTRS TRSMAEDGSP SPEKEKPEKL 120
  121 PFIKYKGAIK YFTESQDIAA SADDVLQWVE KQKDEVVPMA FDMEWPFSFQ TGPGKSAVIQ 180
  181 ICVDEKCCYI YQLTNVKKLP AALVALINHP KVRLHGVNIK NDFRKLARDF PEVTAEPLIE 240
  241 KCVDLGLWCN EVCETGGRWS LERLTNFIAK KAMDKSKKVR MSKWHVIPLD ENQLMYAAID 300
  301 VYIGQVIYRE LERREKVKIK NEEEFKEKNG DAAFKAMKAL GETFLTKINE VTL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..86] PSI-BLAST 6.0 T5 5'-exonuclease
    2 View Details [87..353] PSI-BLAST 31.154902 No description for 2fbtA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • catalytic activity
    		•  0.974539540276602 bayes_pls_golite062009
  • hydrolase activity
    		•  0.819924838862535 bayes_pls_golite062009
  • 5'-3' exonuclease activity
    		•  0.63821154629201 bayes_pls_golite062009
  • exonuclease activity
    		•  0.51931990830742 bayes_pls_golite062009
  • hydrolase activity, acting on ester bonds
    		•  0.0476541893277298 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle