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Protein Overview: ns1-PA

General Information:
Name(s) found: ns1-PA / FBpp0082867 [FlyBase]
Description(s) found:
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  • gi|62510652|sp|Q8MT06.2|GNL3_DROME RecName: Full=Guanine nucleotide-binding protein-like 3 homolog; AltName: Full=Nucleostemin homolog [NCBI NR]
  • gi|28572990|ref|NP_732199.2| CG3983, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|28381326|gb|AAF55384.3| CG3983, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|24647590|ref|NP_650593.1| CG3983, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|23171521|gb|AAN13730.1| CG3983, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|212287978|gb|ACJ23464.1| FI08004p [Drosophila melanogaster] [NCBI NR]
  • Guanine nucleotide-binding protein-like 3 homolog OS=Drosophila melanogaster GN=Ns1 PE=1 SV=2 [Swiss-Prot]
  • The gene nucleostemin 1 is referred to in FlyBase by the symbol Dmel\ns1 (CG3983, FBgn0038473). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:12896245..12898509. It has the cytological map location 89E11. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: GTP binding. There is experimental evidence that it is involved in the biological process</span>: regulation of insulin receptor signaling pathway; regulation of multicellular organism growth. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG3983-PB translation from_gene[CG3983 CG3983 FBgn0038473] seq_release:3 mol_weight=65986 cds_boundaries:(3R:12,896,340..12,898,340[-]) aa_length:581 transcript_info:[CG3983-RB seq_release:3] gene_info:[gene symbol:CG3983 FBgn0038473 gene_boundaries:( [hmr_yeast5_DM3-1_pombe.fasta]
  • >CG3983-PA translation from_gene[CG3983 CG3983 FBgn0038473] seq_release:3 mol_weight=65986 cds_boundaries:(3R:12,896,340..12,898,340[-]) aa_length:581 transcript_info:[CG3983-RA seq_release:3] gene_info:[gene symbol:CG3983 FBgn0038473 gene_boundaries:( [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9VEN7) CG3983-PB (CG3983-PA) [DrosMelano7227.FASTAC.txt]
  • (AE003716) CG3983 gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG3983-PB, isoform B [Drosophila melanogaster]gi|28381326|gb|AAF55384.3| CG3983-PA, isoform A [Drosophila melanogaster]gi|28572990|ref|NP_732199.2| CG3983-PA [Drosophila melanogaster]gi|24647590|ref|NP_650593.1| CG3983-PB [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:complement(12896322..12896497,12896567..12896977,12897041..12897291,12897354..12898239,12898304..12898325); ID=FBpp0082867; name=CG3983-PA; parent=FBgn0038473,FBtr0083426; dbxref=FlyBase:FBpp0082867,FlyBase_Annotation_IDs:CG3983-PA,GB [fly-100309-contam.fasta]
  • CG3983-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG3983-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Guanine nucleotide-binding protein-like 3 homolog (Nucleostemin homolog) [nr-271106-contam.fasta]
  • type=protein; loc=3R:complement(12896322..12896497,12896567..12896977,12897041..12897291,12897354..12898239,12898304..12898325); ID=FBpp0082867; name=CG3983-PA; parent=FBgn0038473,FBtr0083426; dbxref=FlyBase:FBpp0082867,FlyBase_Annotation_IDs:CG3983-PA,GB_protein:AAF55384.3,REFSEQ:NP_732199,GB_protein:AAF55384; MD5=e1b5c619ffb83f545aa2fcb48a0c3100; length=581; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:complement(12896322..12896497,12896567..12896977,12897041..12897291,12897354..12898239,12898304..12898325); ID=FBpp0082867; name=ns1-PA; parent=FBgn0038473,FBtr0083426; dbxref=FlyBase:FBpp0082867,FlyBase_Annotation_IDs:CG3983-PA,GB_protein:AAF55384.3,REFSEQ:NP_732199,GB_protein:AAF55384; MD5=e1b5c619ffb83f545aa2fcb48a0c3100; length=581; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Guanine nucleotide-binding protein-like 3 homolog OS=Drosophila melanogaster GN=ns1 PE=1 SV=2 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • FI08004p OS=Drosophila melanogaster GN=CG3983-RB PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=3R:complement(12896322..12896497,12896567..12896977,12897041..12897291,12897354..12898239,12898304..12898325); ID=FBpp0082867; name=ns1-PA; parent=FBgn0038473,FBtr0083426; dbxref=FlyBase:FBpp0082867,FlyBase_Annotation_IDs:CG3983-PA,GB_protein:AAF55384.3,REFSEQ:NP_732199,GB_protein:AAF55384,FlyMine:FBpp0082867,modMine:FBpp0082867; MD5=e1b5c619ffb83f545aa2fcb48a0c3100; length=581; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • type=protein; loc=3R:complement(join(17072582..17072603,17071632..17072517,17071319..17071569,17070845..17071255,17070600..17070775)); ID=FBpp0082867; name=Ns1-PA; parent=FBgn0038473,FBtr0083426; dbxref=FlyBase:FBpp0082867,FlyBase_Annotation_IDs:CG3983-PA,GB_protein:AAF55384.3,REFSEQ:NP_732199,GB_protein:AAF55384,FlyMine:FBpp0082867,modMine:FBpp0082867; MD5=e1b5c619ffb83f545aa2fcb48a0c3100; length=581; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:complement(join(17072582..17072603,17071632..17072517,17071319..17071569,17070845..17071255,17070600..17070775)); ID=FBpp0082867; name=Ns1-PA; parent=FBgn0038473,FBtr0083426; dbxref=FlyBase:FBpp0082867,FlyBase_Annotation_IDs:CG3983-PA,GB_protein:AAF55384.3,REFSEQ:NP_732199,GB_protein:AAF55384,FlyMine:FBpp0082867,modMine:FBpp0082867; MD5=e1b5c619ffb83f545aa2fcb48a0c3100; length=581; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0082867 type=protein; loc=3R:complement(join(17072582..17072603,17071632..17072517,17071319..17071569,17070845..17071255,17070600..17070775)); ID=FBpp0082867; name=Ns1-PA; parent=FBgn0038473,FBtr0083426; dbxref=FlyBase:FBpp0082867,FlyBase_Annotation_IDs:CG3983-PA,GB_protein:AAF55384.3,REFSEQ:NP_732199,GB_protein:AAF55384,FlyMine:FBpp0082867,modMine:FBpp0082867; MD5=e1b5c619ffb83f545aa2fcb48a0c3100; length=581; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:complement(join(17072582..17072603,17071632..17072517,17071319..17071569,17070845..17071255,17070600..17070775)); ID=FBpp0082867; name=Ns1-PA; parent=FBgn0038473,FBtr0083426; dbxref=FlyBase:FBpp0082867,FlyBase_Annotation_IDs:CG3983-PA,GB_protein:AAF55384.3,REFSEQ:NP_732199,GB_protein:AAF55384,UniProt/Swiss-Prot:Q8MT06,FlyMine:FBpp0082867,modMine:FBpp0082867; MD5=e1b5c619ffb83f545aa2fcb48a0c3100; length=581; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 581 amino acids

    Gene Ontology:
    Cellular Component: nucleolus [IDA]
    Biological Process: regulation of multicellular organism growth [IMP]
    regulation of insulin receptor signaling pathway [IMP]
    Molecular Function: GTP binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MALKRLKTKK SKRLTGRLKH KIEKKVRDHN KKERRAAKKN PKKGSKKQKL IQIPNICPFK  60
   61 DDILKEVEEA KQRQEAERLA RREAFKAERE QNKFKTLESM VEDADMRSTV HGIMHENDAQ 120
  121 DQDEKKYKNA VTKEQSLKQY FKEFRKVIEN ADVVLEVVDA RDPLGTRCNE VERAVRGAPG 180
  181 NKRLVLVLNK ADLVPRENLN NWIKYFRRSG PVTAFKASTQ DQANRLGRRK LREMKTEKAM 240
  241 QGSVCIGAEL LMSMLGNYCR NKGIKTSIRV GVVGIPNVGK SSIINSLTRG RSCMVGSTPG 300
  301 VTKSMQEVEL DSKIKLIDCP GIVFTSGGEN SHAVLKNAQR VGDVKDPFTI AESVLKRASK 360
  361 EYFCTMYDIT NYDTFEEFFA KKAARMGKFL KKGVPDVVAA ARSVLNDWNT GKIKYCTQPP 420
  421 EVQEGQSVHI SASIVHSEAR EFDVENFESM ETEILEHCAV KTDDIMEITS TGPLEIRQPR 480
  481 EEAEPADKIT ASLVIDEKEK PAKGRKRKLD EEKEKVDPSL LLEENQSLNK GIKQMQKLKK 540
  541 KQNVRNEKKI SKITDVLDSF SLGPSSSKAE KYDFDEDYVI E

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..72] Pfam 14.013228 No description for PF08701.2 was found. No confident structure predictions are available.
    2 View Details [73..417] PSI-BLAST 62.522879 No description for 2hjgA was found.
    3 View Details [418..581] PSI-BLAST 44.30103 GTPase Era, N-terminal domain; GTPase Era C-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1 No functions predicted.
    2 No functions predicted.
    3
    Term Confidence Notes
  • transcription regulator activity
    		•  2.56635640666012 bayes_pls_golite062009
  • binding
    		•  1.9759530321894 bayes_pls_golite062009
  • nucleic acid binding
    		•  0.814319647681917 bayes_pls_golite062009
  • structural molecule activity
    		•  0.75789816397165 bayes_pls_golite062009
  • structural constituent of ribosome
    		•  0.710783021654704 bayes_pls_golite062009
  • protein binding
    		•  0.523813050066193 bayes_pls_golite062009
  • DNA binding
    		•  0.37695535646473 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle