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Protein Overview: ND23-PA

General Information:
Name(s) found: ND23-PA / FBpp0082645 [FlyBase]
Description(s) found:
Found 23 descriptions.
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  • The gene NADH:ubiquinone reductase 23kD subunit precursor is referred to in FlyBase by the symbol Dmel\ND23 (CG3944, FBgn0017567). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:11661770..11662819. It has the cytological map location 89A5. Based on sequence similarity, it is predicted to have molecular function</span>: NADH dehydrogenase activity; NADH dehydrogenase (ubiquinone) activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: mitochondrial electron transport, NADH to ubiquinone. 3 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 217 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial respiratory chain complex I [ISS]
    Biological Process: mitochondrial electron transport, NADH to ubiquinone [ISS]
    Molecular Function: NADH dehydrogenase activity [ISS]
    electron carrier activity [IEA]
    NADH dehydrogenase (ubiquinone) activity [ISS]
    4 iron, 4 sulfur cluster binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLTMRIFTA SRNGQRLFGS HGARLLAAQR AEPKDIVEVP KGYVYVNNKE LSMEFADITD  60
   61 RAASTMFFGE LLRGFAVTLA HIFKEPATIN YPFEKGPLSP RFRGEHALRR YPSGEERCIA 120
  121 CKLCEAICPA QAITIEAEER ADGSRRTTRY DIDMTKCIYC GFCQEACPVD AIVEGPNFEF 180
  181 STETHEELLY NKEKLLCNGD KWESEIASNL QADHLYR

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..217] PSI-BLAST 23.69897 Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • NADH dehydrogenase activity
    		•  12.5726198200461 bayes_pls_golite062009
  • NADH dehydrogenase (ubiquinone) activity
    		•  11.5379710261128 bayes_pls_golite062009
  • NADH dehydrogenase (quinone) activity
    		•  11.4267068380664 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
    		•  10.7661444048967 bayes_pls_golite062009
  • oxidoreductase activity, acting on NADH or NADPH
    		•  10.0573871968611 bayes_pls_golite062009
  • oxidoreductase activity
    		•  5.95698221294919 bayes_pls_golite062009
  • electron carrier activity
    		•  5.42600867641421 bayes_pls_golite062009
  • 4 iron, 4 sulfur cluster binding
    		•  4.00434209032307 bayes_pls_golite062009
  • iron-sulfur cluster binding
    		•  3.32581564966388 bayes_pls_golite062009
  • metal cluster binding
    		•  3.32581564966388 bayes_pls_golite062009
  • oxidoreduction-driven active transmembrane transporter activity
    		•  3.29174700910768 bayes_pls_golite062009
  • formate dehydrogenase activity
    		•  2.79579164562277 bayes_pls_golite062009
  • binding
    		•  0.850925220183928 bayes_pls_golite062009
  • catalytic activity
    		•  0.488483980994331 bayes_pls_golite062009
  • protein binding
    		•  0.122045589752402 bayes_pls_golite062009
  • oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor
    		•  0.115812441015069 bayes_pls_golite062009
  • oxidoreductase activity, acting on the aldehyde or oxo group of donors
    		•  0.0827182678048914 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.86

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle