YRC Public Data Repository - Protein Structure Prediction

Protein:	ND23-PA
Organism:	Drosophila melanogaster
Length:	217 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ND23-PA.

Description	E-value	Query Range	Subject Range
gi\|17944955 - gi\|17944955\|gb\|AAL48541.1\| RE02647p [Drosophila melanogaster]	184.0	[0..1]	[217..1]
gi\|195152209, gi... - gi\|195152209\|ref\|XP_002017029.1\| GL21733 [Drosophila persimilis], gi\|194112086\|gb\|EDW34129.1\| GL2173... gi\|54639000, gi\|... - gi\|54639000\|gb\|EAL28402.1\| GA17794 [Drosophila pseudoobscura pseudoobscura], gi\|125776379\|ref\|XP_001... gi\|54639000\|gb\|E... - GA17794-PA [Drosophila pseudoobscura], GA17794 [Drosophila pseudoobscura pseudoobscura]	175.0	[0..1]	[217..1]
NDS8A_ARATH - NADH dehydrogenase [ubiquinone] iron-sulfur protein 8-A, mitochondrial OS=Arabidopsis thaliana GN=At...	171.0	[0..5]	[217..13]
gi\|77416915 - gi\|77416915\|gb\|ABA81853.1\| NADH:ubiquinone oxidoreductase-like [Solanum tuberosum]	166.0	[0..3]	[217..11]
NDUS8_BOVIN - NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial OS=Bos taurus GN=NDUFS8 PE=1 SV...	166.0	[0..31]	[217..26]
NDUS8_MACFA - NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial OS=Macaca fascicularis GN=NDUFS... gi\|109105179 - gi\|109105179\|ref\|XP_001104103.1\| PREDICTED: NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (N...	165.0	[0..38]	[217..31]
gi\|109463301, gi... - gi\|27661165\|ref\|XP_215197.1\| PREDICTED: similar to NADH dehydrogenase (ubiquinone) Fe-S protein 8 [R...	164.0	[0..38]	[217..31]
NDUS8_MOUSE - NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial OS=Mus musculus GN=Ndufs8 PE=1 ...	164.0	[0..38]	[217..31]

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Predicted Domain #1

Region A:
Residues: [1-217]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLTMRIFTA SRNGQRLFGS HGARLLAAQR AEPKDIVEVP KGYVYVNNKE LSMEFADITD  60
   61 RAASTMFFGE LLRGFAVTLA HIFKEPATIN YPFEKGPLSP RFRGEHALRR YPSGEERCIA 120
  121 CKLCEAICPA QAITIEAEER ADGSRRTTRY DIDMTKCIYC GFCQEACPVD AIVEGPNFEF 180
  181 STETHEELLY NKEKLLCNGD KWESEIASNL QADHLYR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	23.69897
Match:	2fug9
Description:	Crystal structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
NADH dehydrogenase activity	12.5726198200461	bayes_pls_golite062009
NADH dehydrogenase (ubiquinone) activity	11.5379710261128	bayes_pls_golite062009
NADH dehydrogenase (quinone) activity	11.4267068380664	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor	10.7661444048967	bayes_pls_golite062009
oxidoreductase activity, acting on NADH or NADPH	10.0573871968611	bayes_pls_golite062009
oxidoreductase activity	5.95698221294919	bayes_pls_golite062009
electron carrier activity	5.42600867641421	bayes_pls_golite062009
4 iron, 4 sulfur cluster binding	4.00434209032307	bayes_pls_golite062009
iron-sulfur cluster binding	3.32581564966388	bayes_pls_golite062009
metal cluster binding	3.32581564966388	bayes_pls_golite062009
oxidoreduction-driven active transmembrane transporter activity	3.29174700910768	bayes_pls_golite062009
formate dehydrogenase activity	2.79579164562277	bayes_pls_golite062009
binding	0.850925220183928	bayes_pls_golite062009
catalytic activity	0.488483980994331	bayes_pls_golite062009
protein binding	0.122045589752402	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor	0.115812441015069	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	0.0827182678048914	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: