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Protein Overview: cv-c-PA

General Information:
Name(s) found: cv-c-PA / FBpp0111543 [FlyBase]
Description(s) found:
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  • gi|24646827|ref|NP_731907.1| crossveinless c, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|23171258|gb|AAF55053.2| crossveinless c, isoform A [Drosophila melanogaster] [NCBI NR]
  • gi|201065603|gb|ACH92211.1| FI03409p [Drosophila melanogaster] [NCBI NR]
  • The gene crossveinless c is referred to in FlyBase by the symbol Dmel\cv-c (CG34389, FBgn0086901). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:10217402..10307410. It has the cytological map location 88B8-88C2. There is experimental evidence that it has the molecular function</span>: GTPase activator activity. There is experimental evidence that it is involved in the biological process</span>: dorsal closure; Malpighian tubule morphogenesis; spiracle morphogenesis, open tracheal system; epidermal growth factor receptor signaling pathway; imaginal disc-derived wing vein morphogenesis; maintenance of epithelial integrity, open tracheal system; head involution; midgut development; open tracheal system development; epithelial cell migration, open tracheal system. 35 alleles are reported. The phenotypes of these alleles are annotated with 23 unique terms, many of which group under: organ system; adult segment; adult mesothoracic segment; spiracle; cephalopharyngeal skeleton; thoracic segment; integumentary specialisation; primordium; pharyngeal sclerite; embryonic hindgut. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • >CG31319-PA translation from_gene[CG31319 RhoGAP88C FBgn0038226] seq_release:3 mol_weight=115195 cds_boundaries:(3R:10,218,519..10,230,859[-]) aa_length:1017 transcript_info:[CG31319-RA seq_release:3] gene_info:[gene symbol:RhoGAP88C synonyms:[CG8480 C [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9VFK2) CG31319 protein [DrosMelano7227.FASTAC.txt]
  • CG31319-PA [Drosophila melanogaster]gi|24646827|ref|NP_731907.1| CG31319-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3R:complement(10218497..10218611,10218674..10218853,10218927..10219199,10219254..10219740,10219833..10221477,10221597..10221748,10225441..10225512,10230711..10230840); ID=FBpp0111543; name=cv-c-PA; parent=FBgn0086901,FBtr0112631; dbxref= [fly-100309-contam.fasta]
  • CG31319-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3R:complement(10218497..10218611,10218674..10218853,10218927..10219199,10219254..10219740,10219833..10221477,10221597..10221748,10225441..10225512,10230711..10230840); ID=FBpp0111543; name=cv-c-PA; parent=FBgn0086901,FBtr0112631; dbxref=GB_protein:AAF55053.2,FlyBase:FBpp0111543,FlyBase:FBpp0082398,FlyBase_Annotation_IDs:CG34389-PA,FlyBase_Annotation_IDs:CG31319-PA,REFSEQ:NP_731907,GB_protein:AAF55053; MD5=c09c2ca993585a27d98d72ddcdb7cee2; length=1017; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3R:complement(10218497..10218611,10218674..10218853,10218927..10219199,10219254..10219740,10219833..10221477,10221597..10221748,10225441..10225512,10230711..10230840); ID=FBpp0111543; name=cv-c-PA; parent=FBgn0086901,FBtr0112631; dbxref=GB_protein:AAF55053.2,FlyBase:FBpp0111543,FlyBase:FBpp0082398,FlyBase_Annotation_IDs:CG34389-PA,FlyBase_Annotation_IDs:CG31319-PA,REFSEQ:NP_731907,GB_protein:AAF55053; MD5=c09c2ca993585a27d98d72ddcdb7cee2; length=1017; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Crossveinless c, isoform A OS=Drosophila melanogaster GN=cv-c PE=1 SV=2 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=3R:complement(10218497..10218611,10218674..10218853,10218927..10219199,10219254..10219740,10219833..10221477,10221597..10221748,10225441..10225512,10230711..10230840); ID=FBpp0111543; name=cv-c-PA; parent=FBgn0086901,FBtr0112631; dbxref=GB_protein:AAF55053.2,FlyBase:FBpp0111543,FlyBase:FBpp0082398,FlyBase_Annotation_IDs:CG34389-PA,FlyBase_Annotation_IDs:CG31319-PA,REFSEQ:NP_731907,GB_protein:AAF55053,FlyMine:FBpp0111543,modMine:FBpp0111543; MD5=c09c2ca993585a27d98d72ddcdb7cee2; length=1017; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • Crossveinless c, isoform A OS=Drosophila melanogaster GN=cv-c PE=2 SV=2 [UniProt_D_Melanogaster_07132012_07-13-2012_reversed.fasta]
  • type=protein; loc=3R:complement(join(14404989..14405118,14399719..14399790,14395875..14396026,14394111..14395755,14393532..14394018,14393205..14393477,14392952..14393131,14392775..14392889)); ID=FBpp0111543; name=cv-c-PA; parent=FBgn0086901,FBtr0112631; dbxref=GB_protein:AAF55053.2,FlyBase:FBpp0111543,FlyBase:FBpp0082398,FlyBase_Annotation_IDs:CG34389-PA,FlyBase_Annotation_IDs:CG31319-PA,REFSEQ:NP_731907,GB_protein:AAF55053,FlyMine:FBpp0111543,modMine:FBpp0111543; MD5=c09c2ca993585a27d98d72ddcdb7cee2; length=1017; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3R:complement(join(14404989..14405118,14399719..14399790,14395875..14396026,14394111..14395755,14393532..14394018,14393205..14393477,14392952..14393131,14392775..14392889)); ID=FBpp0111543; name=cv-c-PA; parent=FBgn0086901,FBtr0112631; dbxref=GB_protein:AAF55053.2,FlyBase:FBpp0111543,FlyBase:FBpp0082398,FlyBase_Annotation_IDs:CG34389-PA,FlyBase_Annotation_IDs:CG31319-PA,REFSEQ:NP_731907,GB_protein:AAF55053,FlyMine:FBpp0111543,modMine:FBpp0111543; MD5=c09c2ca993585a27d98d72ddcdb7cee2; length=1017; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of A8JR05, Crossveinless c, isoform A OS=Drosophila melanogaster GN=cv-c PE=2 SV=2 [DROME.fasta.20160308]
  • FBpp0111543 type=protein; loc=3R:complement(join(14404989..14405118,14399719..14399790,14395875..14396026,14394111..14395755,14393532..14394018,14393205..14393477,14392952..14393131,14392775..14392889)); ID=FBpp0111543; name=cv-c-PA; parent=FBgn0086901,FBtr0112631; dbxref=GB_protein:AAF55053.2,FlyBase:FBpp0111543,FlyBase:FBpp0082398,FlyBase_Annotation_IDs:CG34389-PA,FlyBase_Annotation_IDs:CG31319-PA,REFSEQ:NP_731907,GB_protein:AAF55053,FlyMine:FBpp0111543,modMine:FBpp0111543; MD5=c09c2ca993585a27d98d72ddcdb7cee2; length=1017; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3R:complement(join(14404989..14405118,14399719..14399790,14395875..14396026,14394111..14395755,14393532..14394018,14393205..14393477,14392952..14393131,14392775..14392889)); ID=FBpp0111543; name=cv-c-PA; parent=FBgn0086901,FBtr0112631; dbxref=GB_protein:AAF55053.2,FlyBase:FBpp0111543,FlyBase:FBpp0082398,FlyBase_Annotation_IDs:CG34389-PA,FlyBase_Annotation_IDs:CG31319-PA,REFSEQ:NP_731907,GB_protein:AAF55053,UniProt/TrEMBL:Q9VFK2,FlyMine:FBpp0111543,modMine:FBpp0111543; MD5=c09c2ca993585a27d98d72ddcdb7cee2; length=1017; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 1017 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEA]
    Biological Process: dorsal closure [IMP]
    spiracle morphogenesis, open tracheal system [IMP]
    epithelial cell migration, open tracheal system [IMP]
    midgut development [IMP]
    epidermal growth factor receptor signaling pathway [IGI]
    Malpighian tubule morphogenesis [IMP]
    head involution [IMP]
    imaginal disc-derived wing vein morphogenesis [IMP]
    maintenance of epithelial integrity, open tracheal system [IMP]
    open tracheal system development [IMP]
    Molecular Function: GTPase activator activity [IMP]
    Rho GTPase activator activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQRRMSITIR EYKFFRSFSQ KFENWPKRKA EALWRKMRER KIAEIEAVEA CKWLRAAGFP  60
   61 QYAQMYEDHQ FPIDLNNVAK DHTNLENDQL QSLYRRLCVL NRCATMRLDQ SHKPQTPQQK 120
  121 EESDDENFAL SEHWTFQPHI RRWSRIGEMG LELPPPGLLS LNVEKTESSS KESSPDRFEE 180
  181 DGAGITLVTP GCSKAGGIPN DGSSLGEGSD SGRLRRSGSE RIKDQAKALL RRVESIKSRR 240
  241 RKRQNRENVV ISGPTVLDLS QFGQRSSLRK PDAVYSTPPS PSALSPMHTF PKAPFFGNDL 300
  301 KVPSHSDNFL SPNRSSPKRT PTTPRSMRTS PLHFFSSPMS QLKEGKSDDS SSYYSDSQES 360
  361 STGGKLSLRK PSKARRFLQR TGKVDDIGAH SDSECHQGRK LLIKDANSNT TEVKVKKLTR 420
  421 GGSLNLGKDP KKRDGFRSSS FRSRSTSRKE AKNDEDTAGA TTNGGSKRQP VVRWHSFQME 480
  481 ERPNMIFRKC FSKKIEPLQE DAGGMPFAAM SAGQLQIIRK LALVTLTGHM ERYCPSHRSG 540
  541 WNWELPKFIK KIKMPDYKDK KVFGVPLLMI LQRSGQTLPL AVRAAFRWLQ LNALDQVGIF 600
  601 RKSGGKSRIM KLREQIEVTD STAECMDVFD LQQAYDVADM LKQYFRELPE SLLTTKMSET 660
  661 FVAIFQHLPA EVRLDAVQCA VLLLPDENRE ILYVLLEFLT IVAANSQQNQ MTSNNLGVCL 720
  721 AQSIFHSSIS TGSASVSASP RRKGKGSGMP DMKELAEAKA SHECLSFMIE HYKQIYTAAK 780
  781 EKLSKCNFSY MEESKPLPLE ALGEGMQFHN WRGYLYECTS ATIKEGREKT RGWFSINSLN 840
  841 DSSVDIAYKK VGDGHPLRLW RCSTEIEGPP KEVLEFVIKQ RASWDTNLLQ CQTVKKLDDR 900
  901 TEIYQYALDG QLTTDFCVLR SWQTDLPRGA CVIVETSIDH AKAKPLFGAV RGVVLASRYL 960
  961 IEPCGSGRSR VMHLARVDVK GKTPEWYNKN YGHICSHYLS RIRLAFKHVA DGPESKV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..111] PSI-BLAST 31.221849 No description for 2h80A was found.
    2 View Details [112..281] MSA 3.322996 View MSA. No confident structure predictions are available.
    3 View Details [282..776] PSI-BLAST 50.522879 Crystal Structure of the Human Beta2-Chimaerin
    4 View Details [777..1017] PSI-BLAST 50.69897 No description for 2psoA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • binding
    		•  1.98719702611774 bayes_pls_golite062009
  • protein binding
    		•  1.41065934507744 bayes_pls_golite062009
    2 No functions predicted.
    3
    Term Confidence Notes
  • Rho GTPase activator activity
    		•  1.80530939069504 bayes_pls_golite062009
  • binding
    		•  1.45166365519386 bayes_pls_golite062009
  • epidermal growth factor receptor binding
    		•  1.03934535504406 bayes_pls_golite062009
  • molecular adaptor activity
    		•  0.58947294551094 bayes_pls_golite062009
  • protein binding
    		•  0.572527324734966 bayes_pls_golite062009
  • SH3/SH2 adaptor activity
    		•  0.52889761132084 bayes_pls_golite062009
  • Rac GTPase activator activity
    		•  0.50993873602409 bayes_pls_golite062009
  • insulin receptor binding
    		•  0.28737567192381 bayes_pls_golite062009
  • receptor binding
    		•  0.24683439420295 bayes_pls_golite062009
  • protein binding, bridging
    		•  0.0904972759345899 bayes_pls_golite062009
    4 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle