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Protein Overview: twf-PA

General Information:
Name(s) found: twf-PA / FBpp0082352 [FlyBase]
Description(s) found:
Found 24 descriptions.
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  • The gene twinfilin is referred to in FlyBase by the symbol Dmel\twf (CG3172, FBgn0038206). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:9948380..9950199. It has the cytological map location 88A9. Based on sequence similarity, it is predicted to have molecular function</span>: protein tyrosine kinase activity. There is experimental evidence that it is involved in the biological process</span>: regulation of lamellipodium assembly; actin filament depolymerization; bristle morphogenesis. 3 alleles are reported. The phenotypes of these alleles are annotated with: trichome; interommatidial bristle; macrochaeta; chaeta; actin filament; microchaeta; ommatidium. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 343 amino acids

    Gene Ontology:
    Cellular Component: intracellular [IEA]
    Biological Process: regulation of lamellipodium assembly [IMP]
    bristle morphogenesis [IMP]
    actin filament depolymerization [IDA]
    Molecular Function: protein tyrosine kinase activity [ISS]
    actin binding [IEA][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSHQTGIRAN EQLAKVFGKA KNGKFRVIKV SIENEQLSCG ATAETKKDWE RDYDKLIGPL  60
   61 LEKDVPCYIL YRLDAKIPLG YSWLLISWTP DTASIRQKMV YASTKATLKT EFGSAYITEE 120
  121 LHATTLDECT LEGYRRHKQD FAAPAPLTSR EEELKELRKT EVHTEINTNT RHQTLGGINC 180
  181 PLSEATVAAV QDLVRGKHDY LQFRIDLEEE QIHVSRAAKV ELADLPKQVP EDHARYHLFL 240
  241 FRHTHEGDYF ESYVFVYSMP GYSCSVRERM MYSSCKAPFL DELAALGVEV VKKLEIDSGS 300
  301 ELTEAFLQDE LHPKKILHRP AFAKPKGPPN RGAKRLTRPT AED

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..142] PSI-BLAST 44.0 Adf-H domain of twinfilin isoform-1
    2 View Details [143..343] PSI-BLAST 34.522879 No description for 2d8bA was found.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • actin binding
    		•  7.52071741004022 bayes_pls_golite062009
  • cytoskeletal protein binding
    		•  6.04859625643932 bayes_pls_golite062009
  • actin filament binding
    		•  5.45532510538573 bayes_pls_golite062009
  • binding
    		•  2.41877859618486 bayes_pls_golite062009
  • protein kinase activity
    		•  2.22634235673758 bayes_pls_golite062009
  • protein binding
    		•  1.87981807141519 bayes_pls_golite062009
  • protein tyrosine kinase activity
    		•  1.87091423399482 bayes_pls_golite062009
  • phosphotransferase activity, alcohol group as acceptor
    		•  1.67227267699496 bayes_pls_golite062009
  • kinase activity
    		•  1.55883505515498 bayes_pls_golite062009
  • phosphatidylinositol-4,5-bisphosphate binding
    		•  1.3406661967545 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  1.30213296029859 bayes_pls_golite062009
  • molecular transducer activity
    		•  1.14209355225632 bayes_pls_golite062009
  • signal transducer activity
    		•  1.14209355225632 bayes_pls_golite062009
  • transferase activity
    		•  0.591259446255369 bayes_pls_golite062009
  • structural constituent of cytoskeleton
    		•  0.482954032096802 bayes_pls_golite062009
  • structural molecule activity
    		•  0.391701411061931 bayes_pls_golite062009
  • actin monomer binding
    		•  0.224304003054399 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle