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Protein Overview: CG14740-PA

General Information:
Name(s) found: CG14740-PA / FBpp0082025 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG14740 (CG14740, FBgn0037988). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:7886792..7888666. It has the cytological map location 87A6. Based on sequence similarity, it is predicted to have molecular function</span>: citrate (Si)-synthase activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: citrate metabolic process; tricarboxylic acid cycle. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 478 amino acids

    Gene Ontology:
    Cellular Component: mitochondrial matrix [ISS]
    Biological Process: cellular carbohydrate metabolic process [IEA]
    citrate metabolic process [ISS]
    tricarboxylic acid cycle [ISS]
    Molecular Function: citrate (Si)-synthase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQKTNNYKSF KIFFKNVPFR SYPDCKNGKG SGLKAKLAKK IPIEREKFLG IKCLHGKKII  60
   61 GQISVNSVIG GMRGLPLLFC ETSSLDKNKG IYYRGKLLKD VCAKLPRVQE GTQEGTPEGC 120
  121 FFLLTSGSMP TKKEAQEVTN EWLKRGSVPR YCLRMIDSMD KRVHPMAQLC AASACLNPQS 180
  181 QFVEAYTKGA RRADYWKYSY EDSMNLIAML PTVAAAIYSN VFRDGEGSRE VNYEEDWSGN 240
  241 FCRMLGLPEK DFVDLMRLYM ILHADHESGN VSAHACHLVG TALSDPFLSF SASMCGLAGP 300
  301 LHGLANQEVL VWLTKLRKAI GDDPSDEELK KFIDDTLKGG QVIPGYGHAV LRDTDPRFVL 360
  361 QNEFAMKHCK DDPGVKLVTR LWKIIPEVLK KLNKVANPYP NVDAHSGVLL QHYCLKELKF 420
  421 YTVLFGVSRA LGVLSQLIWS RALGAPIERP KSFSSIEICK FINEADKKAG KKNNKKKC

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..478] PSI-BLAST 141.0 CRYSTALLOGRAPHIC REFINEMENT AND ATOMIC MODELS OF TWO DIFFERENT FORMS OF CITRATE SYNTHASE AT 2.7 AND 1.7 ANGSTROMS RESOLUTION

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • citrate (Si)-synthase activity
    		•  7.90380661459876 bayes_pls_golite062009
  • transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer
    		•  7.35970609422108 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  4.98392594633005 bayes_pls_golite062009
  • catalytic activity
    		•  2.51855037019879 bayes_pls_golite062009
  • transferase activity
    		•  2.22659761972612 bayes_pls_golite062009
  • binding
    		•  1.15467737113069 bayes_pls_golite062009
  • protein binding
    		•  0.210158634792359 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.84

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle