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Protein Overview: HisCl1-PA

General Information:
Name(s) found: HisCl1-PA / FBpp0081946 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene Histamine-gated chloride channel subunit 1 is referred to in FlyBase by the symbol Dmel\HisCl1 (CG14723, FBgn0037950). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:7612898..7615115. It has the cytological map location 86F7-86F8. Based on sequence similarity, it is predicted to have molecular function</span>: extracellular-glycine-gated ion channel activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: ion transport. 7 alleles are reported. No phenotypic data is available. It has 4 annotated transcripts and 4 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 426 amino acids

    Gene Ontology:
    Cellular Component: histamine-gated chloride channel complex [NAS]
    postsynaptic membrane [IEA]
    integral to membrane [IEA]
    Biological Process: ion transport [IEA]
    Molecular Function: histamine-gated chloride channel activity [NAS]
    extracellular-glycine-gated ion channel activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQSPTSKLVE FRCLIALAIY LHALEQSIQH CHCVHGYRNN TESAELVSHY ESSLSLPDIL  60
   61 PIPSKTYDKN RAPKLLGQPT VVYFHVTVLS LDSINEESMT YVTDIFLAQS WRDPRLRLPE 120
  121 NMSEQYRILD VDWLHSIWRP DCFFKNAKKV TFHEMSIPNH YLWLYHDKTL LYMSKLTLVL 180
  181 SCAMKFESYP HDTQICSMMI ESLSHTVEDL VFIWNMTDPL VVNTEIELPQ LDISNNYTTD 240
  241 CTIEYSTGNF TCLAIVFNLR RRLGYHLFHT YIPSALIVVM SWISFWIKPE AIPARVTLGV 300
  301 TSLLTLATQN TQSQQSLPPV SYVKAIDVWM SSCSVFVFLS LMEFAVVNNF MGPVATKAMK 360
  361 GYSDENISDL DDLKSALQHH RESIIEPQYD TFCHGHATAI YIDKFSRFFF PFSFFILNIV 420
  421 YWTTFL

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..426] PSI-BLAST 61.045757 Refined structure of the nicotinic acetylcholine receptor at 4A resolution.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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