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Protein Overview: CG6574-PA

General Information:
Name(s) found: CG6574-PA / FBpp0081773 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG6574 (CG6574, FBgn0037846). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:6686251..6688710. It has the cytological map location 86C7. Based on sequence similarity, it is predicted to have molecular function</span>: reduced folate carrier activity. An electronic pipeline based on InterPro domains suggests that it is involved in the biological process</span>: transport. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 444 amino acids

    Gene Ontology:
    Cellular Component: membrane [IEA]
    Biological Process: transport [IEA]
    Molecular Function: reduced folate carrier activity [ISS]
    folic acid binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKEWLKISCL LCVFGCIREI RPSEPYVTEY LLGPWRNITE QQLTHDVYPV GTYSYLVQLV  60
   61 FVFLITDFLR YKPLIITIGA AGVIIWSMLI WTTSLLSLQI LEFFFGTYMA AEVAYYTYIY 120
  121 AKVDKKYYAR VTSHTRAAMF AGKLVSGITS QLMLNLELMN YKELNYITLG TQIIAMLWAF 180
  181 GLPRVDRSLY FHREQLSITE PQTQLPGVGN LAEMDQQQEN TQKQPGALSL LWLHFRNAYT 240
  241 NPRVVQWSLW YAIGLAGYLQ VTYYVQVLWK VIEPEPVIAW NGAVDAVLTA LAALSALAAG 300
  301 YLHTGRLRPR ASLLILGILS AVEGGCVLIC CWTQDIYWSY AGFVLFGALY GFTITVASAE 360
  361 VARNLEEESF GLVFGVNTFV ALIFQSLLTI IFVTDTGFEL DPVGQYTAYA FYFIGVGVLY 420
  421 LISVLIEYLM CRNNDVEKLE NSLD

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..444] PSI-BLAST 15.0 Crystal Structure of the Glycerol-3-Phosphate Transporter from E.Coli

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transporter activity
    		•  4.09176719149278 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  3.59744164024479 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  3.5865018981083 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  3.54194478414824 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  2.21266150105753 bayes_pls_golite062009
  • cation transmembrane transporter activity
    		•  1.79369588808394 bayes_pls_golite062009
  • active transmembrane transporter activity
    		•  1.59419818573076 bayes_pls_golite062009
  • secondary active transmembrane transporter activity
    		•  1.22264637452409 bayes_pls_golite062009
  • polyol transmembrane transporter activity
    		•  0.924836669821548 bayes_pls_golite062009
  • alcohol transmembrane transporter activity
    		•  0.924836669821548 bayes_pls_golite062009
  • glycerol transmembrane transporter activity
    		•  0.812001619402678 bayes_pls_golite062009
  • binding
    		•  0.805286077372817 bayes_pls_golite062009
  • symporter activity
    		•  0.74591237387473 bayes_pls_golite062009
  • solute:cation symporter activity
    		•  0.74591237387473 bayes_pls_golite062009
  • sugar:hydrogen symporter activity
    		•  0.143419068761182 bayes_pls_golite062009
  • cation:sugar symporter activity
    		•  0.143419068761182 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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