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Protein Overview: hb-PB, hb-PA

General Information:
Name(s) found: hb-PA / FBpp0081432 [FlyBase]
hb-PB / FBpp0081431 [FlyBase]
Description(s) found:
Found 40 descriptions.
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  • The gene hunchback is referred to in FlyBase by the symbol Dmel\hb (CG9786, FBgn0001180). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:4517038..4523540. It has the cytological map location 85A5. There is experimental evidence that it has the molecular function</span>: transcription activator activity; SUMO binding; DNA binding. There is experimental evidence that it is involved in the biological process</span>: torso signaling pathway; terminal region determination; neuroblast fate determination; positive regulation of transcription. 122 alleles are reported. The phenotypes of these alleles are annotated with 71 unique terms, many of which group under: thoracic segment; organ system; embryonic segment; cephalopharyngeal skeleton; embryonic neuron; embryonic nervous system; embryonic abdomen; nervous system; U neuron; primordium. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene hunchback is referred to in FlyBase by the symbol Dmel\hb (CG9786, FBgn0001180). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:4517038..4523540. It has the cytological map location 85A5. There is experimental evidence that it has the molecular function</span>: transcription activator activity; SUMO binding; DNA binding. There is experimental evidence that it is involved in the biological process</span>: torso signaling pathway; terminal region determination; neuroblast fate determination; positive regulation of transcription. 122 alleles are reported. The phenotypes of these alleles are annotated with 71 unique terms, many of which group under: thoracic segment; organ system; embryonic segment; cephalopharyngeal skeleton; embryonic neuron; embryonic nervous system; embryonic abdomen; nervous system; U neuron; primordium. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 758 amino acids

    Gene Ontology:
    Cellular Component: nucleus [NAS]
    intracellular [IEA]
    Biological Process: torso signaling pathway [IGI]
    regulation of cell fate specification [TAS]
    posterior head segmentation [TAS]
    terminal region determination [IGI]
    anterior/posterior axis specification, embryo [NAS]
    regulation of development, heterochronic [TAS]
    anterior region determination [NAS]
    positive regulation of transcription [IDA]
    neuroblast fate determination [IEP][IMP]
    trunk segmentation [TAS]
    salivary gland development [TAS]
    zygotic determination of anterior/posterior axis, embryo [NAS][TAS]
    regulation of transcription [NAS]
    open tracheal system development [TAS]
    ganglion mother cell fate determination [TAS]
    morphogenesis of a branching structure [TAS]
    ventral cord development [NAS]
    epithelial cell migration, open tracheal system [TAS]
    central nervous system development [TAS]
    Molecular Function: DNA binding [IDA]
    SUMO binding [IPI]
    zinc ion binding [IEA]
    specific RNA polymerase II transcription factor activity [NAS]
    transcription activator activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQNWETTATT NYEQHNAWYN SMFAANIKQE PGHHLDGNSV ASSPRQSPIP STNHLEQFLK  60
   61 QQQQQLQQQP MDTLCAMTPS PSQNDQNSLQ HYDANLQQQL LQQQQYQQHF QAAQQQHHHH 120
  121 HHLMGGFNPL TPPGLPNPMQ HFYGGNLRPS PQPTPTSAST IAPVAVATGS SEKLQALTPP 180
  181 MDVTPPKSPA KSSQSNIEPE KEHDQMSNSS EDMKYMAESE DDDTNIRMPI YNSHGKMKNY 240
  241 KCKTCGVVAI TKVDFWAHTR THMKPDKILQ CPKCPFVTEF KHHLEYHIRK HKNQKPFQCD 300
  301 KCSYTCVNKS MLNSHRKSHS SVYQYRCADC DYATKYCHSF KLHLRKYGHK PGMVLDEDGT 360
  361 PNPSLVIDVY GTRRGPKSKN GGPIASGGSG SGSRKSNVAA VAPQQQQSQP AQPVATSQLS 420
  421 AALQGFPLVQ GNSAPPAASP VLPLPASPAK SVASVEQTPS LPSPANLLPP LASLLQQNRN 480
  481 MAFFPYWNLN LQMLAAQQQA AVLAQLSPRM REQLQQQNQQ QSDNEEEEQD DEYERKSVDS 540
  541 AMDLSQGTPV KEDEQQQQPQ QPLAMNLKVE EEATPLMSSS NASRRKGRVL KLDTLLQLRS 600
  601 EAMTSPEQLK VPSTPMPTAS SPIAGRKPMP EEHCSGTSSA DESMETAHVP QANTSASSTA 660
  661 SSSGNSSNAS SNSNGNSSSN SSSNGTTSAV AAPPSGTPAA AGAIYECKYC DIFFKDAVLY 720
  721 TIHMGYHSCD DVFKCNMCGE KCDGPVGLFV HMARNAHS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..210] MSA 1.46297 View MSA. No confident structure predictions are available.
    2 View Details [211..418] PSI-BLAST 58.0 No description for 2i13A was found.
    3 View Details [419..579] deduced N/A No confident structure predictions are available.
    4 View Details [580..692] deduced N/A No confident structure predictions are available.
    5 View Details [693..758] PSI-BLAST 8.522879 ADR1 DNA-BINDING DOMAIN FROM SACCHAROMYCES CEREVISIAE, NMR, 25 STRUCTURES


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle