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Protein Overview: sec8-PA

General Information:
Name(s) found: sec8-PA / FBpp0078326 [FlyBase]
Description(s) found:
Found 20 descriptions.
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  • The gene sec8 is referred to in FlyBase by the symbol Dmel\sec8 (CG2095, FBgn0086685). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:1580654..1584699. It has the cytological map location 83C2. Its molecular function is unknown. There is experimental evidence that it is involved in the biological process</span>: regulation of synapse structure and activity. 10 alleles are reported. The phenotypes of these alleles are annotated with: NMJ bouton; larval neuromuscular junction; neurite. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 985 amino acids

    Gene Ontology:
    Cellular Component: plasma membrane [IDA]
    exocyst [IEA][ISS][NAS]
    rhabdomere [IDA]
    Biological Process: synaptic vesicle targeting [NAS]
    synaptic vesicle docking during exocytosis [NAS]
    vesicle-mediated transport [ISS]
    protein transport [IEA]
    vesicle docking during exocytosis [IEA]
    regulation of synapse structure and activity [IMP]
    neurotransmitter secretion [NAS]
    Molecular Function: NONE FOUND


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDAPPPTKPP RGVKYGKDES AGCGFLVNVI KSLGFSETTE ERQKEKQKIE AEFKRSDLRL  60
   61 NELVSRHDQQ LTQVLPLFSQ VSSEVTASRE RIHAVKENLG VCKRLLQCRR DELRKMWMDA 120
  121 VQHKYVLEML EQIQELRKVP QRVVGYTAKR QYLHASKALT DALTTLNGPL QAVEGLSDLR 180
  181 TDLQTRRQQL YQRLHEELVT QVYTNSANEA LSSFQRTNSS RLNSSFTRGI GARRSTDRIE 240
  241 ANARVRKALA EMAQSFDLDK AEVIEDADLI YPELSMSYFV AIIVESFGML HKVPDSLETL 300
  301 RVQIQTELLN VVRHTTHQLS VSGATADTNP LLSLLEVIFK QFKAIAKTHS LLLKNYLSVG 360
  361 QKYSVVGPQP YDLTDFWAQA QSVLQLLLTD YLDIQNAAAD ESAQTGFSEP TSNINSYFLR 420
  421 RKVPSTKRSM FKFDKSSHVG TSNNSDAFKE HRRNASDASV DDNLAGQLGG SGKGSTSGLF 480
  481 PHEKKQREKI LICTPDQSII TKVYLPLMGY IKEIENFMKC KPGQPCSLHD FLDNYIKDTF 540
  541 LTKGHNRNLQ LTIESLSKNQ DAWRTIISPE EIKALNLSRP LLQSTVMVER RLMETKNLIQ 600
  601 DLPCYSEDLL KMVCALLKAY REICQAAYRG IVQPDSEDKR IYSVAWLKDE DISRFLKTLP 660
  661 NWTDLKTYSQ KSRHNRKLHR GSFEPSEEES PLQVQQRNIR EAEMLTSNLG EGGITQQEIL 720
  721 VEISVLKELA ILQESMEWFS CRVSEFANDL RRPLVNGLNA VPAECGADIA VKDGTIKVMT 780
  781 NLALEFDELA NTCLLVLHLE VRVQCFHYLR SKSSVRTNSY VGSKDDILEP DRQVQVLTKR 840
  841 LSEMDEAFSA TLHPRKTRYI FEGLAHLASR ILIQASNYLE HIDQITVQRM CRNAIALQQT 900
  901 LSNITASREV ALDQARHFYE LLCMEPDEIL NALLERGTQF SEMQLLNALQ LSCKSFGITD 960
  961 ANLLASYQQK LSDILGAKPS KGVVV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..435] PSI-BLAST 18.154902 Heavy meromyosin subfragment
    2 View Details [436..487] deduced N/A No confident structure predictions are available.
    3 View Details [488..985] FFAS03 0.995 Crystal Structure of Sec15 C-terminal domain


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle