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Protein Overview: CG12007-PA

General Information:
Name(s) found: CG12007-PA / FBpp0078483 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • This gene is referred to in FlyBase by the symbol Dmel\CG12007 (CG12007, FBgn0037293). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:953810..955665. It has the cytological map location 82F1. Based on sequence similarity, it is predicted to have molecular function</span>: Rab geranylgeranyltransferase activity. There is experimental evidence that it is involved in the biological process</span>: regulation of cell shape; cell adhesion. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 515 amino acids

    Gene Ontology:
    Cellular Component: Rab-protein geranylgeranyltransferase complex [ISS]
    Biological Process: regulation of cell shape [IMP]
    cell adhesion [IMP]
    protein amino acid prenylation [IEA]
    Molecular Function: Rab geranylgeranyltransferase activity [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHGRVKVRTT EEERERKKKE QALKVRAYRA AMGRIQKKRE AGELDNEMLS LTVQILLRNP  60
   61 DVSMLWNIRR ECVLEKLFRL KEEEATCETP SEEKPEKENQ TGENKPSEKK AAGEDKAHSI 120
  121 FTCELDLTEQ CLMVNPKSYN AWHHRCWTLE QNPRADWQQE VKLCNKYLKF DERNFHTWDY 180
  181 RRYVTGKAMV PATQELDFCT EKIRANFSNY SSWHHRSLLL PELYPNQQRD RPMSEEKLQK 240
  241 ELEMVLTAAF TDPNDSSAWF YQRWLLGSGA QLDRAPRIAA FRLESHGAVL ALDKPYPDIK 300
  301 QLKTELVGGG QTILLEFWLP VDKRGTSWKC QQNFDYQRNS AYSLRLSDQK VDLSPLSGSE 360
  361 NGAYYIAPPH GTTSCSKDLL AELQTQLQSC LDLLEFEPDS KWTLLTSALL MRAIDFSANH 420
  421 ETSLAHLAKL EKVDFLREGY YKDLAARWTL EWELAKWPQS ADFPKRFDIA NAVLLESLPY 480
  481 DQYLVIADEI TLPNKLRDKL GESVPKTFAD LKLQS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..515] PSI-BLAST 30.09691 Rab geranylgeranyltransferase alpha-subunit, N-terminal domain; Rab geranylgeranyltransferase alpha-subunit, insert domain; Rab geranylgeranyltransferase alpha-subunit, C-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • Rab geranylgeranyltransferase activity
    		•  13.555288199339 bayes_pls_golite062009
  • protein prenyltransferase activity
    		•  12.9872042326453 bayes_pls_golite062009
  • protein geranylgeranyltransferase activity
    		•  12.5639792024732 bayes_pls_golite062009
  • prenyltransferase activity
    		•  10.9012508257439 bayes_pls_golite062009
  • protein farnesyltransferase activity
    		•  5.75066035906508 bayes_pls_golite062009
  • CAAX-protein geranylgeranyltransferase activity
    		•  3.82151622786875 bayes_pls_golite062009
  • binding
    		•  1.8899885235914 bayes_pls_golite062009
  • transferase activity
    		•  0.972106146880383 bayes_pls_golite062009
  • catalytic activity
    		•  0.60409960326459 bayes_pls_golite062009
  • protein binding
    		•  0.455938814211606 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle