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Protein Overview: tacc-PC

General Information:
Name(s) found: tacc-PC / FBpp0088892 [FlyBase]
Description(s) found:
Found 21 descriptions.
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  • The gene transforming acidic coiled-coil protein is referred to in FlyBase by the symbol Dmel\tacc (CG9765, FBgn0026620). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3R:560134..574777. It has the cytological map location 82D2. There is experimental evidence that it has the molecular function</span>: protein binding. There is experimental evidence that it is involved in the biological process</span>: protein localization; pronuclear migration; mitosis; microtubule cytoskeleton organization; nuclear migration. 29 alleles are reported. The phenotypes of these alleles are annotated with: pronucleus; mitotic cell cycle; centrosome; spindle; microtubule; astral microtubule; pericentriolar material; aster. It has 10 annotated transcripts and 10 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1308 amino acids

    Gene Ontology:
    Cellular Component: pericentriolar material [NAS]
    spindle microtubule [TAS]
    centrosome [IDA][TAS]
    spindle pole [IDA]
    astral microtubule [TAS]
    Biological Process: pronuclear migration [IMP]
    female meiosis [TAS]
    mitotic spindle organization [TAS]
    nuclear migration [IMP]
    pronuclear fusion [TAS]
    protein localization [IMP][TAS]
    negative regulation of microtubule depolymerization [NAS][TAS]
    mitosis [IMP][NAS]
    microtubule cytoskeleton organization [IMP]
    Molecular Function: protein binding [IPI]
    microtubule binding [TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDFLANIIKR PKSIATTGIS TNQPTTMEAL EAASPADECS TPRDKGGVTL VSAHLDSLLE  60
   61 SASEELQRLE GKHCELFMES ISNPLPAPED STDSREEIQK FLSEINFNLN QVSANEMEHL 120
  121 QAMSGELSPL AVKPSPKPTS MDQQKAMAAA LGHQTAVPGG LKPEDDLVPK FGGLPEFDET 180
  181 QIPELAPLST DMDTQLKSNH SDSDVFVECL SLHSERYTGD RSELEAYSSA LNDVLEQQLS 240
  241 MTSVSTLGAE FNDPLAVSQH NNVSYEAMDV DDLNETMEML KDVLNAEDRH LMQTHILSVT 300
  301 QSKPENNFVH YHPNQEQNRV ELDQLAKHSK PNSDAKESES LVESVLSEES GTQSFEPKLT 360
  361 LSALDSTKDL AKHQEEMQTN TKDIFQKEKH HPVSSAQVKD AQNPKEPEKA LNLKEASSEL 420
  421 STKSAKSLEY PNQEKQFSVA VESMERPCTA ISLEQNASPA MEATEDRTVE ELDQMDVDES 480
  481 MKVDDATVLN SCRQEQINAH SPVSSKFFLK LCVQNDTDCQ DNKMDQKTAG KESALKMTEI 540
  541 ELPVESVPSA SLSPPTPALQ AKIIELSLSP PIPTHRPKTA EELEFLALRE LPLPDGVSTA 600
  601 GKVECKQLSH GLVPIVAVLP TPLYLDLKGN TTTASLPEPT SPSFPIKEPA EKQSHFPRSP 660
  661 RAQLEQKDMP YLEEAVVERS SHRKQSDFGV IAKSPIVFEL TQPSPEKQHL NETLPMSEIS 720
  721 PTSSNMTFDS GSITEDKSQK GTENIEPSST LAVSLGSVDD KQRRTFSVVQ PTKEEEEAKS 780
  781 RRTFCMENEN PRRTFCMQQN ASPAVEATED TGADEVMDVD ISMRADEVAV MKSHQQTWKE 840
  841 RQAPISNSPP IPTHQRLNRP PEAISPVSPL GNGTVVLEEQ TLSAKEQATL SASDEKDDVF 900
  901 LEHFGAISPV SDDMFKTSSA SNNQAKFRVN ADEETGGKGA SAMIRKRSGT AGEQEEIFDA 960
  961 EFHDGVNNQN RSNSVPIDRS SLLLKFDPLL GAPVPVNHPN QQEQALQNIL GSNQHQNRLL1020
 1021 SPTLEEHETS DGNQSFGVIS SAKDTAKKWD FKPPVDRTKK HVKMSVDVID NDCNKTFDNS1080
 1081 NTNTEDKTHN YNDMDELEKK IKNEVTRSED IEKKLKEGEL REEALIKRIT EKDKTNAKLN1140
 1141 GVIEAYEKAI AELISEKEQQ AQLHERQLQE VQADRDANYH HLTSLETTFS DLHVKYEKSK1200
 1201 EMTSQLKSNE ESLLAERKQM MDNLRLQEQR YDKMKNHAMQ QLEIANKKLD TYSREHADET1260
 1261 KKLKALLKKE EISRVSMTEQ LQQKSRENAD LLKICEELIY GKGQGGSS

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..349] PSI-BLAST 16.221849 Heavy meromyosin subfragment
    2 View Details [350..501] PSI-BLAST 6.0 No description for 2fxmA was found.
    3 View Details [502..628] deduced N/A No confident structure predictions are available.
    4 View Details [629..695] deduced N/A No confident structure predictions are available.
    5 View Details [696..939] deduced N/A No confident structure predictions are available.
    6 View Details [940..1036] deduced N/A No confident structure predictions are available.
    7 View Details [1037..1308] PSI-BLAST 7.0 Tropomyosin


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle