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Protein Overview: AP-2-PB

General Information:
Name(s) found: AP-2-PB / FBpp0078072 [FlyBase]
Description(s) found:
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  • gi|3776230|gb|AAC64676.1| transcription factor AP-2 [Drosophila melanogaster] [NCBI NR]
  • gi|23094266|gb|AAN12183.1| AP-2, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|21358029|ref|NP_649336.1| AP-2, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|17945415|gb|AAL48762.1| RE17884p [Drosophila melanogaster] [NCBI NR]
  • The gene AP-2 is referred to in FlyBase by the symbol Dmel\AP-2 (CG7807, FBgn0023417). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:21591958..21606453. It has the cytological map location 78D8-78E1. There is experimental evidence that it has the molecular function</span>: sequence-specific DNA binding; specific RNA polymerase II transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: positive regulation of gene-specific transcription from RNA polymerase II promoter; proboscis development; imaginal disc-derived leg morphogenesis; imaginal disc-derived leg joint morphogenesis. 27 alleles are reported. The phenotypes of these alleles are annotated with 15 unique terms, many of which group under: adult segment; organ system; mouthpart; nervous system; peripheral nervous system; adult mesothoracic segment; thoracic segment; adult brain; multi-cell-component structure; adult somatic muscle; adult; external compound sense organ. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • >CG7807-PB translation from_gene[CG7807 AP-2 FBgn0023417] seq_release:3 mol_weight=51124 cds_boundaries:(3L:21,516,560..21,530,229[+]) aa_length:465 transcript_info:[CG7807-RB seq_release:3] gene_info:[gene symbol:AP-2 FBgn0023417 gene_boundaries:(3L:2 [hmr_yeast5_DM3-1_pombe.fasta]
  • (O96378) Transcription factor AP-2 (RE17884p) (CG7807-PB) [DrosMelano7227.FASTAC.txt]
  • CG7807-PB, isoform B [Drosophila melanogaster]gi|17945415|gb|AAL48762.1| RE17884p [Drosophila melanogaster]gi|21358029|ref|NP_649336.1| CG7807-PB [Drosophila melanogaster]gi|3776230|gb|AAC64676.1| transcription factor AP-2 [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3L:join(21592382..21592438,21602519..21602749,21602819..21602986,21604243..21604450,21605095..21605284,21605345..21605609,21605713..21605880,21605944..21606054); ID=FBpp0078072; name=AP-2-PB; parent=FBgn0023417,FBtr0078418; dbxref=FlyBas [fly-100309-contam.fasta]
  • RE17884p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • transcription factor AP-2 [Drosophila melanogaster] [nr-271106-contam.fasta]
  • AP-2 CG7807-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG7807-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3L:join(21592382..21592438,21602519..21602749,21602819..21602986,21604243..21604450,21605095..21605284,21605345..21605609,21605713..21605880,21605944..21606054); ID=FBpp0078072; name=AP-2-PB; parent=FBgn0023417,FBtr0078418; dbxref=FlyBase:FBpp0078072,FlyBase_Annotation_IDs:CG7807-PB,GB_protein:AAN12183.1,REFSEQ:NP_649336,GB_protein:AAN12183; MD5=f0a72c79f50992cbed5d5044849d7779; length=465; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3L:join(21592382..21592438,21602519..21602749,21602819..21602986,21604243..21604450,21605095..21605284,21605345..21605609,21605713..21605880,21605944..21606054); ID=FBpp0078072; name=AP-2-PB; parent=FBgn0023417,FBtr0078418; dbxref=FlyBase:FBpp0078072,FlyBase_Annotation_IDs:CG7807-PB,GB_protein:AAN12183.1,REFSEQ:NP_649336,GB_protein:AAN12183; MD5=f0a72c79f50992cbed5d5044849d7779; length=465; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • AP-2, isoform B OS=Drosophila melanogaster GN=AP-2 PE=1 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=3L:join(21592382..21592438,21602519..21602749,21602819..21602986,21604243..21604450,21605095..21605284,21605345..21605609,21605713..21605880,21605944..21606054); ID=FBpp0078072; name=AP-2-PB; parent=FBgn0261953,FBtr0078418; dbxref=FlyBase:FBpp0078072,FlyBase_Annotation_IDs:CG7807-PB,GB_protein:AAN12183.1,REFSEQ:NP_649336,GB_protein:AAN12183,FlyMine:FBpp0078072,modMine:FBpp0078072; MD5=f0a72c79f50992cbed5d5044849d7779; length=465; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • AP-2, isoform B OS=Drosophila melanogaster GN=AP-2 PE=2 SV=1 [UniProt_D_Melanogaster_07132012_07-13-2012_reversed.fasta]
  • type=protein; loc=3L:join(21599282..21599338,21609419..21609649,21609719..21609886,21611143..21611350,21611995..21612184,21612245..21612509,21612613..21612780,21612844..21612954); ID=FBpp0078072; name=TfAP-2-PB; parent=FBgn0261953,FBtr0078418; dbxref=FlyBase:FBpp0078072,FlyBase_Annotation_IDs:CG7807-PB,GB_protein:AAN12183.1,REFSEQ:NP_649336,GB_protein:AAN12183,FlyMine:FBpp0078072,modMine:FBpp0078072; MD5=f0a72c79f50992cbed5d5044849d7779; length=465; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3L:join(21599282..21599338,21609419..21609649,21609719..21609886,21611143..21611350,21611995..21612184,21612245..21612509,21612613..21612780,21612844..21612954); ID=FBpp0078072; name=TfAP-2-PB; parent=FBgn0261953,FBtr0078418; dbxref=FlyBase:FBpp0078072,FlyBase_Annotation_IDs:CG7807-PB,GB_protein:AAN12183.1,REFSEQ:NP_649336,GB_protein:AAN12183,FlyMine:FBpp0078072,modMine:FBpp0078072; MD5=f0a72c79f50992cbed5d5044849d7779; length=465; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of M9PIH9, RE17884p OS=Drosophila melanogaster GN=TfAP-2 PE=2 SV=1 [DROME.fasta.20160308]
  • FBpp0078072 type=protein; loc=3L:join(21599282..21599338,21609419..21609649,21609719..21609886,21611143..21611350,21611995..21612184,21612245..21612509,21612613..21612780,21612844..21612954); ID=FBpp0078072; name=TfAP-2-PB; parent=FBgn0261953,FBtr0078418; dbxref=FlyBase:FBpp0078072,FlyBase_Annotation_IDs:CG7807-PB,GB_protein:AAN12183.1,REFSEQ:NP_649336,GB_protein:AAN12183,FlyMine:FBpp0078072,modMine:FBpp0078072; MD5=f0a72c79f50992cbed5d5044849d7779; length=465; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3L:join(21599282..21599338,21609419..21609649,21609719..21609886,21611143..21611350,21611995..21612184,21612245..21612509,21612613..21612780,21612844..21612954); ID=FBpp0078072; name=TfAP-2-PB; parent=FBgn0261953,FBtr0078418; dbxref=FlyBase:FBpp0078072,FlyBase_Annotation_IDs:CG7807-PB,GB_protein:AAN12183.1,REFSEQ:NP_649336,GB_protein:AAN12183,UniProt/TrEMBL:O96378,FlyMine:FBpp0078072,modMine:FBpp0078072; MD5=f0a72c79f50992cbed5d5044849d7779; length=465; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 465 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IC][IEA]
    Biological Process: imaginal disc-derived leg joint morphogenesis [IMP]
    imaginal disc-derived leg morphogenesis [IMP]
    regulation of transcription, DNA-dependent [IEA][ISS]
    positive regulation of gene-specific transcription from RNA polymerase II promoter [IDA]
    proboscis development [IMP]
    Molecular Function: transcription factor activity [ISS]
    RNA polymerase II transcription factor activity [NAS]
    specific RNA polymerase II transcription factor activity [IDA]
    sequence-specific DNA binding [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHILHRTNDH QFEDQKFMME RLSGHGSLGL SSGSAAYTTH SGGHTGRSGP ATGHSGHSST  60
   61 HGSAATMHHQ SLQSDFQPPY FPPPFHHSTQ SPPQQQNHGA LEYLGTDPYG QPLSSLHHAP 120
  121 LHHYNQLAGL RSTQDQLGIH RTHREAELQG HVTQLSHGFP YTDRRSDYGS AISAGAAHGT 180
  181 RLGHEHESLA LHQALQNAVD DVQAPALDDN VAFMSDLPLI KSMKSGKEAG NIGSGSPSEV 240
  241 FCAVPGRLSL LSSTSKYKVT IAEVQRRLSP PECLNASLLG GVLRRAKSKN GGRLLREKLE 300
  301 KIGLNLPAGR RKAANVTLLT SLVEGEATHL AKDFHFVCET EFPARQLAEY IVRHQTEPQD 360
  361 SYRRKELILH SQQITKELMQ ILSQDRTTHF GTRSQHLLEP SMQRHLTHFS LITHGFGSPA 420
  421 IMAVLHAFQT FLNESLNYLE KLYPSNGGGM VSSSLDKSKI DNEKK

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.40

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle