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Protein Overview: Syx7-PB, Syx7-PA

General Information:
Name(s) found: Syx7-PB / FBpp0078008 [FlyBase]
Syx7-PA / FBpp0078007 [FlyBase]
Description(s) found:
Found 36 descriptions.
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  • The gene Syntaxin 7 is referred to in FlyBase by the symbol Dmel\Syx7 (CG5081, FBgn0086377). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:21438922..21441235. It has the cytological map location 78D2. Based on sequence similarity, it is predicted to have molecular function</span>: SNAP receptor activity. There is experimental evidence that it is involved in the biological process</span>: endosomal vesicle fusion; establishment or maintenance of polarity of follicular epithelium; establishment or maintenance of apical/basal cell polarity; positive regulation of endocytosis; regulation of epithelial cell proliferation; negative regulation of cell proliferation. 10 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
  • The gene Syntaxin 7 is referred to in FlyBase by the symbol Dmel\Syx7 (CG5081, FBgn0086377). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:21438922..21441235. It has the cytological map location 78D2. Based on sequence similarity, it is predicted to have molecular function</span>: SNAP receptor activity. There is experimental evidence that it is involved in the biological process</span>: endosomal vesicle fusion; establishment or maintenance of polarity of follicular epithelium; establishment or maintenance of apical/basal cell polarity; positive regulation of endocytosis; regulation of epithelial cell proliferation; negative regulation of cell proliferation. 10 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 282 amino acids

    Gene Ontology:
    Cellular Component: early endosome [IDA]
    membrane [IEA]
    plasma membrane [ISS][NAS]
    Biological Process: establishment or maintenance of apical/basal cell polarity [IMP]
    synaptic vesicle docking during exocytosis [ISS]
    vesicle-mediated transport [NAS]
    positive regulation of endocytosis [IMP]
    negative regulation of cell proliferation [IMP]
    endosomal vesicle fusion [IMP]
    regulation of epithelial cell proliferation [IMP]
    establishment or maintenance of polarity of follicular epithelium [IMP]
    neurotransmitter secretion [NAS]
    Molecular Function: protein binding [IEA]
    SNAP receptor activity [ISS][NAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDLQHMENGL SGGGGGGLSE IDFQRLAQII ATSIQKVQQN VSTMQRMVNQ LNTPQDSPEL  60
   61 KKQLHQIMTY TNQLVTDTNN QINEVDKCKE RHLKIQRDRL VDEFTAALTA FQSVQRKTAD 120
  121 IEKTALRQAR GDSYNIARPP GSSRTGSSNS SASQQDNNSF FEDNFFNRKS NQQQMQTQME 180
  181 EQADLQALEE QEQVIRELEN NIVGVNEIYK KLGALVYEQG LTVDSIESQV EQTSIFVSQG 240
  241 TENLRKASSY RNKVRKKKLI LVGILSAVLL AIILILVFQF KN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..282] PSI-BLAST 28.221849 Syntaxin 1A N-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • SNAP receptor activity
    		•  3.50393203740159 bayes_pls_golite062009
  • protein binding
    		•  2.66728689880621 bayes_pls_golite062009
  • binding
    		•  2.33192450173199 bayes_pls_golite062009
  • transporter activity
    		•  1.74189664015129 bayes_pls_golite062009
  • substrate-specific transporter activity
    		•  1.2360389745429 bayes_pls_golite062009
  • transmembrane transporter activity
    		•  1.13101548288086 bayes_pls_golite062009
  • protein transporter activity
    		•  0.81087535212264 bayes_pls_golite062009
  • SNARE binding
    		•  0.71459772253941 bayes_pls_golite062009
  • substrate-specific transmembrane transporter activity
    		•  0.398018181744571 bayes_pls_golite062009
  • extracellular ligand-gated ion channel activity
    		•  0.27873535382283 bayes_pls_golite062009
  • excitatory extracellular ligand-gated ion channel activity
    		•  0.27873535382283 bayes_pls_golite062009
  • ion transmembrane transporter activity
    		•  0.0981818568206971 bayes_pls_golite062009
  • phospholipid binding
    		•  0.0172309833091902 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle