Protein Overview: park-PB, park-PC

General Information:
Name(s) found:	park-PC / FBpp0077975 [FlyBase] park-PB / FBpp0077974 [FlyBase]
Description(s) found: Found 37 descriptions. SHOW ALL	The gene parkin is referred to in FlyBase by the symbol Dmel\park (CG10523, FBgn0041100). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:21187849..21189953. It has the cytological map location 78C2. There is experimental evidence that it has the molecular function</span>: ubiquitin conjugating enzyme binding; ubiquitin-protein ligase activity. There is experimental evidence that it is involved in the biological process</span>: protein autoubiquitination; mitochondrial fission; response to oxidative stress; negative regulation of JNK cascade; regulation of mitochondrion organization; mitochondrion organization; protein ubiquitination; spermatogenesis. 32 alleles are reported. The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: organ system; anatomical structure; cytoplasmic part; male germline cyst; elongation stage spermatid; adult segment; intracellular membrane-bounded organelle; adult; adult mesothoracic segment; adult somatic muscle. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase] The gene parkin is referred to in FlyBase by the symbol Dmel\park (CG10523, FBgn0041100). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:21187849..21189953. It has the cytological map location 78C2. There is experimental evidence that it has the molecular function</span>: ubiquitin conjugating enzyme binding; ubiquitin-protein ligase activity. There is experimental evidence that it is involved in the biological process</span>: protein autoubiquitination; mitochondrial fission; response to oxidative stress; negative regulation of JNK cascade; regulation of mitochondrion organization; mitochondrion organization; protein ubiquitination; spermatogenesis. 32 alleles are reported. The phenotypes of these alleles are annotated with 14 unique terms, many of which group under: organ system; anatomical structure; cytoplasmic part; male germline cyst; elongation stage spermatid; adult segment; intracellular membrane-bounded organelle; adult; adult mesothoracic segment; adult somatic muscle. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	482 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	response to oxidative stress [IMP] spermatogenesis [IMP] regulation of mitochondrion organization [IMP] negative regulation of JNK cascade [IDA] mitochondrion organization [IMP] protein autoubiquitination [IDA] protein ubiquitination [IDA] mitochondrial fission [IGI]
Molecular Function:	ubiquitin-protein ligase activity [IDA] zinc ion binding [IEA] ubiquitin conjugating enzyme binding [IPI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSFIFKFIAT FVRKMLELLQ FGGKTLTHTL SIYVKTNTGK TLTVNLEPQW DIKNVKELVA  60
   61 PQLGLQPDDL KIIFAGKELS DATTIEQCDL GQQSVLHAIR LRPPVQRQKI QSATLEEEEP 120
  121 SLSDEASKPL NETLLDLQLE SEERLNITDE ERVRAKAHFF VHCSQCDKLC NGKLRVRCAL 180
  181 CKGGAFTVHR DPECWDDVLK SRRIPGHCES LEVACVDNAA GDPPFAEFFF KCAEHVSGGE 240
  241 KDFAAPLNLI KNNIKNVPCL ACTDVSDTVL VFPCASQHVT CIDCFRHYCR SRLGERQFMP 300
  301 HPDFGYTLPC PAGCEHSFIE EIHHFKLLTR EEYDRYQRFA TEEYVLQAGG VLCPQPGCGM 360
  361 GLLVEPDCRK VTCQNGCGYV FCRNCLQGYH IGECLPEGTG ASATNSCEYT VDPNRAAEAR 420
  421 WDEASNVTIK VSTKPCPKCR TPTERDGGCM HMVCTRAGCG FEWCWVCQTE WTRDCMGAHW 480
  481 FG

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.98

Protein Overview: park-PB, park-PC

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: