Protein Overview: Six4-PA, Six4-PB

General Information:
Name(s) found:	Six4-PB / FBpp0077933 [FlyBase] Six4-PA / FBpp0077932 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|7547018\|gb\|AAF63760.1\|AF247709_1 myotonix [Drosophila melanogaster] [NCBI NR] gi\|5106878\|gb\|AAD39864.1\|AF099185_1 homeobox protein SIX4 [Drosophila melanogaster] [NCBI NR] gi\|24667695\|ref\|NP_730566.1\| Six4, isoform B [Drosophila melanogaster] [NCBI NR] gi\|23094187\|gb\|AAN12144.1\| Six4, isoform B [Drosophila melanogaster] [NCBI NR] gi\|23094186\|gb\|AAF51640.3\| Six4, isoform A [Drosophila melanogaster] [NCBI NR] gi\|21356333\|ref\|NP_649256.1\| Six4, isoform A [Drosophila melanogaster] [NCBI NR] gi\|162951733\|gb\|ABY21728.1\| GM13131p [Drosophila melanogaster] [NCBI NR] gi\|115646658\|gb\|ABI34233.2\| RT01127p [Drosophila melanogaster] [NCBI NR] gi\|115646558\|gb\|ABI34201.2\| RT01027p [Drosophila melanogaster] [NCBI NR] The gene Six4 is referred to in FlyBase by the symbol Dmel\Six4 (CG3871, FBgn0027364). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:20781986..20785868. It has the cytological map location 77E6. Based on sequence similarity, it is predicted to have molecular function</span>: RNA polymerase II transcription factor activity. There is experimental evidence that it is involved in the biological process</span>: myoblast fusion; gonad development; fat body development; mesoderm development. 9 alleles are reported. The phenotypes of these alleles are annotated with 11 unique terms, many of which group under: anatomical structure; organ system; organism; embryonic/larval hypodermal muscle; adult; embryo; developing anatomical structure; late extended germ band embryo; germline cell; embryonic somatic muscle; ventral longitudinal muscle; primordium; gonad. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase] >CG3871-PA translation from_gene[CG3871 Six4 FBgn0027364] seq_release:3 mol_weight=43672 cds_boundaries:(3L:20,707,086..20,710,304[-]) aa_length:392 transcript_info:[CG3871-RA seq_release:3] gene_info:[gene symbol:Six4 FBgn0027364 gene_boundaries:(3L:2 [hmr_yeast5_DM3-1_pombe.fasta] >CG3871-PB translation from_gene[CG3871 Six4 FBgn0027364] seq_release:3 mol_weight=43672 cds_boundaries:(3L:20,707,086..20,710,304[-]) aa_length:392 transcript_info:[CG3871-RB seq_release:3] gene_info:[gene symbol:Six4 FBgn0027364 gene_boundaries:(3L:2 [hmr_yeast5_DM3-1_pombe.fasta] (Q9Y1P6) Homeobox protein SIX4 (MYOTONIX) (CG3871 protein) [DrosMelano7227.FASTAC.txt] CG3871-PB, isoform B [Drosophila melanogaster]gi\|23094186\|gb\|AAF51640.3\| CG3871-PA, isoform A [Drosophila melanogaster]gi\|7547018\|gb\|AAF63760.1\| myotonix [Drosophila melanogaster]gi\|24667695\|ref\|NP_730566.1\| CG3871-PB [Drosophila melanogaster]gi\|21356 [nrdb_11152004_Chlamydomonas] type=protein; loc=3L:complement(20782166..20782271,20783236..20783753,20783820..20784214,20785228..20785387); ID=FBpp0077932; name=Six4-PA; parent=FBgn0027364,FBtr0078274; dbxref=FlyBase:FBpp0077932,FlyBase_Annotation_IDs:CG3871-PA,GB_protein:AAF51640.3,R [fly-100309-contam.fasta] type=protein; loc=3L:complement(20782166..20782271,20783236..20783753,20783820..20784214,20785228..20785387); ID=FBpp0077933; name=Six4-PB; parent=FBgn0027364,FBtr0078275; dbxref=FlyBase:FBpp0077933,FlyBase_Annotation_IDs:CG3871-PB,GB_protein:AAN12144.1,R [fly-100309-contam.fasta] Six4 CG3871-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta] myotonix [Drosophila melanogaster] [nr-271106-contam.fasta] homeobox protein SIX4 [Drosophila melanogaster] [nr-271106-contam.fasta] RT01027p [Drosophila melanogaster] [nr-271106-contam.fasta] CG3871-PA, isoform A [Drosophila melanogaster] [nr-271106-contam.fasta] RT01127p [Drosophila melanogaster] [nr-271106-contam.fasta] Six4 CG3871-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta] CG3871-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=3L:complement(20782166..20782271,20783236..20783753,20783820..20784214,20785228..20785387); ID=FBpp0077932; name=Six4-PA; parent=FBgn0027364,FBtr0078274; dbxref=FlyBase:FBpp0077932,FlyBase_Annotation_IDs:CG3871-PA,GB_protein:AAF51640.3,REFSEQ:NP_649256,GB_protein:AAF51640; MD5=b214ab46de98f6201e01615cf7a9a856; length=392; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=3L:complement(20782166..20782271,20783236..20783753,20783820..20784214,20785228..20785387); ID=FBpp0077933; name=Six4-PB; parent=FBgn0027364,FBtr0078275; dbxref=FlyBase:FBpp0077933,FlyBase_Annotation_IDs:CG3871-PB,GB_protein:AAN12144.1,REFSEQ:NP_730566,GB_protein:AAN12144; MD5=b214ab46de98f6201e01615cf7a9a856; length=392; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=3L:complement(20782166..20782271,20783236..20783753,20783820..20784214,20785228..20785387); ID=FBpp0077932; name=Six4-PA; parent=FBgn0027364,FBtr0078274; dbxref=FlyBase:FBpp0077932,FlyBase_Annotation_IDs:CG3871-PA,GB_protein:AAF51640.3,REFSEQ:NP_649256,GB_protein:AAF51640; MD5=b214ab46de98f6201e01615cf7a9a856; length=392; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] type=protein; loc=3L:complement(20782166..20782271,20783236..20783753,20783820..20784214,20785228..20785387); ID=FBpp0077933; name=Six4-PB; parent=FBgn0027364,FBtr0078275; dbxref=FlyBase:FBpp0077933,FlyBase_Annotation_IDs:CG3871-PB,GB_protein:AAN12144.1,REFSEQ:NP_730566,GB_protein:AAN12144; MD5=b214ab46de98f6201e01615cf7a9a856; length=392; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] GM13131p OS=Drosophila melanogaster GN=Six4 PE=2 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta] type=protein; loc=3L:complement(20782166..20782271,20783236..20783753,20783820..20784214,20785228..20785387); ID=FBpp0077932; name=Six4-PA; parent=FBgn0027364,FBtr0078274; dbxref=FlyBase:FBpp0077932,FlyBase_Annotation_IDs:CG3871-PA,GB_protein:AAF51640.3,REFSEQ:NP_649256,GB_protein:AAF51640,FlyMine:FBpp0077932,modMine:FBpp0077932; MD5=b214ab46de98f6201e01615cf7a9a856; length=392; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=3L:complement(20782166..20782271,20783236..20783753,20783820..20784214,20785228..20785387); ID=FBpp0077933; name=Six4-PB; parent=FBgn0027364,FBtr0078275; dbxref=FlyBase:FBpp0077933,FlyBase_Annotation_IDs:CG3871-PB,GB_protein:AAN12144.1,REFSEQ:NP_730566,GB_protein:AAN12144; MD5=b214ab46de98f6201e01615cf7a9a856; length=392; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=3L:complement(join(20792128..20792287,20790720..20791114,20790136..20790653,20789066..20789171)); ID=FBpp0077932; name=Six4-PA; parent=FBgn0027364,FBtr0078274; dbxref=FlyBase:FBpp0077932,FlyBase_Annotation_IDs:CG3871-PA,GB_protein:AAF51640.3,REFSEQ:NP_649256,GB_protein:AAF51640,FlyMine:FBpp0077932,modMine:FBpp0077932; MD5=b214ab46de98f6201e01615cf7a9a856; length=392; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=3L:complement(join(20792128..20792287,20790720..20791114,20790136..20790653,20789066..20789171)); ID=FBpp0077933; name=Six4-PB; parent=FBgn0027364,FBtr0078275; dbxref=FlyBase:FBpp0077933,FlyBase_Annotation_IDs:CG3871-PB,GB_protein:AAN12144.1,REFSEQ:NP_730566,GB_protein:AAN12144; MD5=b214ab46de98f6201e01615cf7a9a856; length=392; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=3L:complement(join(20792128..20792287,20790720..20791114,20790136..20790653,20789066..20789171)); ID=FBpp0077932; name=Six4-PA; parent=FBgn0027364,FBtr0078274; dbxref=FlyBase:FBpp0077932,FlyBase_Annotation_IDs:CG3871-PA,GB_protein:AAF51640.3,REFSEQ:NP_649256,GB_protein:AAF51640,FlyMine:FBpp0077932,modMine:FBpp0077932; MD5=b214ab46de98f6201e01615cf7a9a856; length=392; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] type=protein; loc=3L:complement(join(20792128..20792287,20790720..20791114,20790136..20790653,20789066..20789171)); ID=FBpp0077933; name=Six4-PB; parent=FBgn0027364,FBtr0078275; dbxref=FlyBase:FBpp0077933,FlyBase_Annotation_IDs:CG3871-PB,GB_protein:AAN12144.1,REFSEQ:NP_730566,GB_protein:AAN12144; MD5=b214ab46de98f6201e01615cf7a9a856; length=392; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] FBpp0077932 type=protein; loc=3L:complement(join(20792128..20792287,20790720..20791114,20790136..20790653,20789066..20789171)); ID=FBpp0077932; name=Six4-PA; parent=FBgn0027364,FBtr0078274; dbxref=FlyBase:FBpp0077932,FlyBase_Annotation_IDs:CG3871-PA,GB_protein:AAF51640.3,REFSEQ:NP_649256,GB_protein:AAF51640,FlyMine:FBpp0077932,modMine:FBpp0077932; MD5=b214ab46de98f6201e01615cf7a9a856; length=392; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] FBpp0077933 type=protein; loc=3L:complement(join(20792128..20792287,20790720..20791114,20790136..20790653,20789066..20789171)); ID=FBpp0077933; name=Six4-PB; parent=FBgn0027364,FBtr0078275; dbxref=FlyBase:FBpp0077933,FlyBase_Annotation_IDs:CG3871-PB,GB_protein:AAN12144.1,REFSEQ:NP_730566,GB_protein:AAN12144; MD5=b214ab46de98f6201e01615cf7a9a856; length=392; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=3L:complement(join(20792128..20792287,20790720..20791114,20790136..20790653,20789066..20789171)); ID=FBpp0077932; name=Six4-PA; parent=FBgn0027364,FBtr0078274; dbxref=FlyBase:FBpp0077932,FlyBase_Annotation_IDs:CG3871-PA,GB_protein:AAF51640.3,REFSEQ:NP_649256,GB_protein:AAF51640,UniProt/TrEMBL:Q9Y1P6,FlyMine:FBpp0077932,modMine:FBpp0077932; MD5=b214ab46de98f6201e01615cf7a9a856; length=392; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta] type=protein; loc=3L:complement(join(20792128..20792287,20790720..20791114,20790136..20790653,20789066..20789171)); ID=FBpp0077933; name=Six4-PB; parent=FBgn0027364,FBtr0078275; dbxref=FlyBase:FBpp0077933,FlyBase_Annotation_IDs:CG3871-PB,GB_protein:AAN12144.1,REFSEQ:NP_730566,GB_protein:AAN12144,UniProt/TrEMBL:Q9Y1P6; MD5=b214ab46de98f6201e01615cf7a9a856; length=392; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	392 amino acids
Gene Ontology:
Cellular Component:	nucleus [ISS]
Biological Process:	gonad development [IMP][NAS] myoblast fusion [IMP] mesoderm development [IMP] regulation of transcription, DNA-dependent [IEA] regulation of transcription [IEA][ISS] fat body development [IMP]
Molecular Function:	transcription factor activity [IEA] RNA polymerase II transcription factor activity [ISS][NAS] sequence-specific DNA binding [IEA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFDKNLDGNN LSVSIGGDLD STSSGGTSSD HSAVHQDNLS SPMAYGSLFL PNAGYRGNLS  60
   61 CKTVLQLDKF APYEGVEKDH LLERRFQDIT NDYDKSPPPT ASTTPTHYPS LNSIIFENGS 120
  121 SGNLGDLNGN TKTDLCAGLQ RSGGGLGGNA GSGGHLISNL TAAHNMSAVS SFPIDAKMLQ 180
  181 FSTDQIQCMC EALQQKGDIE KLTTFLCSLP PSEFFKTNES VLRARAMVAY NLGQFHELYN 240
  241 LLETHCFSIK YHVDLQNLWF KAHYKEAEKV RGRPLGAVDK YRLRKKYPLP KTIWDGEETV 300
  301 YCFKEKSRNA LKDCYLTNRY PTPDEKKTLA KKTGLTLTQV SNWFKNRRQR DRTPQQRPDI 360
  361 MSVLPVGQLD GNGFPRMFNA PSYYPETIFN GQ

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: Six4-PA, Six4-PB

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: