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Protein Overview: trbl-PA

General Information:
Name(s) found: trbl-PA / FBpp0077893 [FlyBase]
Description(s) found:
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  • gi|7296300|gb|AAF51590.1| tribbles [Drosophila melanogaster] [NCBI NR]
  • gi|6715320|gb|AAF26374.1|AF204688_1 Tribbles [Drosophila melanogaster] [NCBI NR]
  • gi|28557569|gb|AAO45190.1| RH69304p [Drosophila melanogaster] [NCBI NR]
  • gi|17864238|ref|NP_524672.1| tribbles [Drosophila melanogaster] [NCBI NR]
  • The gene tribbles is referred to in FlyBase by the symbol Dmel\trbl (CG5408, FBgn0028978). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:20389388..20394708. It has the cytological map location 77C1. Based on sequence similarity, it is predicted to have molecular function</span>: protein serine/threonine kinase activity. There is experimental evidence that it is involved in the biological process</span>: ventral furrow formation; negative regulation of mitosis; regulation of cell cycle. 30 alleles are reported. The phenotypes of these alleles are annotated with 22 unique terms, many of which group under: organ system; peripheral nervous system; gastrula embryo; portion of tissue; nervous system; female germline cyst; external compound sense organ; germarium; ventral furrow; external sensory organ precursor cell; mitotic domain 1; cell cycle; adult segment. It has one annotated transcript and one annotated polypeptide. [FlyBase]
  • >CG5408-PA translation from_gene[CG5408 trbl FBgn0028978] seq_release:3 mol_weight=54078 cds_boundaries:(3L:20,315,392..20,319,793[-]) aa_length:484 transcript_info:[CG5408-RA seq_release:3] gene_info:[gene symbol:trbl FBgn0028978 gene_boundaries:(3L:2 [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q9V3Z1) Putative TRBL protein (CG5408 protein) (RH69304p) [DrosMelano7227.FASTAC.txt]
  • (AE003591) trbl gene product [Drosophila melanogaster] [yeastflysequest.fasta]
  • CG5408-PA [Drosophila melanogaster]gi|28557569|gb|AAO45190.1| RH69304p [Drosophila melanogaster]gi|6715320|gb|AAF26374.1| Tribbles [Drosophila melanogaster]gi|17864238|ref|NP_524672.1| CG5408-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=3L:complement(20389951..20390575,20393526..20394355); ID=FBpp0077893; name=trbl-PA; parent=FBgn0028978,FBtr0078235; dbxref=FlyBase:FBpp0077893,FlyBase_Annotation_IDs:CG5408-PA,GB_protein:AAF51590.1,REFSEQ:NP_524672,GB_protein:AAF51590; M [fly-100309-contam.fasta]
  • tribbles CG5408-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG5408-PA [Drosophila melanogaster] [nr-271106-contam.fasta]
  • RH69304p [Drosophila melanogaster] [nr-271106-contam.fasta]
  • Tribbles [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=3L:complement(20389951..20390575,20393526..20394355); ID=FBpp0077893; name=trbl-PA; parent=FBgn0028978,FBtr0078235; dbxref=FlyBase:FBpp0077893,FlyBase_Annotation_IDs:CG5408-PA,GB_protein:AAF51590.1,REFSEQ:NP_524672,GB_protein:AAF51590; MD5=a79012cfa57e190774620df15a40f392; length=484; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=3L:complement(20389951..20390575,20393526..20394355); ID=FBpp0077893; name=trbl-PA; parent=FBgn0028978,FBtr0078235; dbxref=FlyBase:FBpp0077893,FlyBase_Annotation_IDs:CG5408-PA,GB_protein:AAF51590.1,REFSEQ:NP_524672,GB_protein:AAF51590; MD5=a79012cfa57e190774620df15a40f392; length=484; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • RH69304p OS=Drosophila melanogaster GN=trbl PE=1 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=3L:complement(20389951..20390575,20393526..20394355); ID=FBpp0077893; name=trbl-PA; parent=FBgn0028978,FBtr0078235; dbxref=FlyBase:FBpp0077893,FlyBase_Annotation_IDs:CG5408-PA,GB_protein:AAF51590.1,REFSEQ:NP_524672,GB_protein:AAF51590,FlyMine:FBpp0077893,modMine:FBpp0077893; MD5=a79012cfa57e190774620df15a40f392; length=484; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • RH69304p OS=Drosophila melanogaster GN=trbl PE=2 SV=1 [UniProt_D_Melanogaster_07132012_07-13-2012_reversed.fasta]
  • type=protein; loc=3L:complement(join(20400426..20401255,20396851..20397475)); ID=FBpp0077893; name=trbl-PA; parent=FBgn0028978,FBtr0078235; dbxref=FlyBase:FBpp0077893,FlyBase_Annotation_IDs:CG5408-PA,GB_protein:AAF51590.1,REFSEQ:NP_524672,GB_protein:AAF51590,FlyMine:FBpp0077893,modMine:FBpp0077893; MD5=a79012cfa57e190774620df15a40f392; length=484; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=3L:complement(join(20400426..20401255,20396851..20397475)); ID=FBpp0077893; name=trbl-PA; parent=FBgn0028978,FBtr0078235; dbxref=FlyBase:FBpp0077893,FlyBase_Annotation_IDs:CG5408-PA,GB_protein:AAF51590.1,REFSEQ:NP_524672,GB_protein:AAF51590,FlyMine:FBpp0077893,modMine:FBpp0077893; MD5=a79012cfa57e190774620df15a40f392; length=484; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • FBpp0077893 type=protein; loc=3L:complement(join(20400426..20401255,20396851..20397475)); ID=FBpp0077893; name=trbl-PA; parent=FBgn0028978,FBtr0078235; dbxref=FlyBase:FBpp0077893,FlyBase_Annotation_IDs:CG5408-PA,GB_protein:AAF51590.1,REFSEQ:NP_524672,GB_protein:AAF51590,FlyMine:FBpp0077893,modMine:FBpp0077893; MD5=a79012cfa57e190774620df15a40f392; length=484; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=3L:complement(join(20400426..20401255,20396851..20397475)); ID=FBpp0077893; name=trbl-PA; parent=FBgn0028978,FBtr0078235; dbxref=FlyBase:FBpp0077893,FlyBase_Annotation_IDs:CG5408-PA,GB_protein:AAF51590.1,REFSEQ:NP_524672,GB_protein:AAF51590,UniProt/TrEMBL:Q9V3Z1,FlyMine:FBpp0077893,modMine:FBpp0077893; MD5=a79012cfa57e190774620df15a40f392; length=484; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 484 amino acids

    Gene Ontology:
    Cellular Component: NONE FOUND
    Biological Process: negative regulation of mitosis [IGI][IMP]
    ventral furrow formation [IGI]
    regulation of cell cycle [IMP]
    protein amino acid phosphorylation [IEA]
    gastrulation [NAS]
    Molecular Function: ATP binding [IEA]
    protein kinase activity [IEA]
    protein serine/threonine kinase activity [ISS][TAS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDNSSGQNSR TASSASTSKI VNYSSPVSPG VAAATSSSSS SSSSGMSSSQ EDTVLGLFTP  60
   61 KKEFPNAKML QTIREKLMTP GGACDLLALG IAAEPTDQQP VKLIQQRYLI SAQPSHISAA 120
  121 VAAKTPASYR HLVDLTASNL RCVDIFTGEQ FLCRIVNEPL HKVQRAYFQL QQHDEELRRS 180
  181 TIYGHPLIRP VHDIIPLTKD RTYILIAPVP QERDSTGGVT GVYENLHTYI RHAKRLCETE 240
  241 ARAIFHQICQ TVQVCHRNGI ILRDLKLKRF YFIDEARTKL QYESLEGSMI LDGEDDTLSD 300
  301 KIGCPLYTAP ELLCPQQTYK GKPADMWSLG VILYTMLVGQ YPFYEKANCN LITVIRHGNV 360
  361 QIPLTLSKSV RWLLLSLLRK DYTERMTASH IFLTPWLREQ RPFHMYLPVD VEVAEDWSDA 420
  421 EEDEGTAADA MDDDEEGLCP LGDKHEYEDI GVEPLDYTRS TLQMAQNANG LSTEPEPDTD 480
  481 VDMG

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data



    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.68

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle