Protein Overview: trpml-PA, CG42638-PA

General Information:
Name(s) found:	CG42638-PA / FBpp0291489 [FlyBase] trpml-PA / FBpp0074720 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|7293750\|gb\|AAF49118.1\| CG8743 [Drosophila melanogaster] [NCBI NR] gi\|21357401\|ref\|NP_649145.1\| CG8743 [Drosophila melanogaster] [NCBI NR] gi\|17944586\|gb\|AAL48180.1\| SD02261p [Drosophila melanogaster] [NCBI NR] This gene is referred to in FlyBase by the symbol Dmel\CG42638 (CG42638, FBgn0261361). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:19738934..19742819. It has the cytological map location 76C3. Its molecular function is unknown. The biological processes in which it is involved are not known. No alleles are reported. It has one annotated transcript and one annotated polypeptide. [FlyBase] The gene transient receptor potential mucolipin is referred to in FlyBase by the symbol Dmel\trpml (CG8743, FBgn0036904). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:19706960..19711450. It has the cytological map location 76C2. Based on sequence similarity, it is predicted to have molecular function</span>: calcium channel activity. There is experimental evidence that it is involved in the biological process</span>: cellular calcium ion homeostasis; negative regulation of growth or development of symbiont in host; autophagy. 11 alleles are reported. The phenotypes of these alleles are annotated with: rhabdomere; S2 cell-line; larval neuromuscular junction; eye photoreceptor cell; mitochondrion; adult brain. It has one annotated transcript and one annotated polypeptide. [FlyBase] >CG8743-PA translation from_gene[CG8743 CG8743 FBgn0036904] seq_release:3 mol_weight=74252 cds_boundaries:(3L:19,665,229..19,668,025[-]) aa_length:652 transcript_info:[CG8743-RA seq_release:3] gene_info:[gene symbol:CG8743 FBgn0036904 gene_boundaries:( [hmr_yeast5_DM3-1_pombe.fasta] (Q9VW35) CG8743 protein (SD02261p) [DrosMelano7227.FASTAC.txt] (AE003516) CG8743 gene product [Drosophila melanogaster] [yeastflysequest.fasta] CG8743-PA [Drosophila melanogaster]gi\|17944586\|gb\|AAL48180.1\| SD02261p [Drosophila melanogaster]gi\|21357401\|ref\|NP_649145.1\| CG8743-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas] type=protein; loc=3L:complement(19708369..19709107,19709248..19710098,19710800..19711168); ID=FBpp0074720; name=CG8743-PA; parent=FBgn0036904,FBtr0074952; dbxref=FlyBase:FBpp0074720,FlyBase_Annotation_IDs:CG8743-PA,GB_protein:AAF49118.1,REFSEQ:NP_649145,G [fly-100309-contam.fasta] CG8743-PA [Drosophila melanogaster] [nr-271106-contam.fasta] SD02261p [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=3L:complement(19708369..19709107,19709248..19710098,19710800..19711168); ID=FBpp0074720; name=CG8743-PA; parent=FBgn0036904,FBtr0074952; dbxref=FlyBase:FBpp0074720,FlyBase_Annotation_IDs:CG8743-PA,GB_protein:AAF49118.1,REFSEQ:NP_649145,GB_protein:AAF49118; MD5=7cc9399738e46bec7b049f6eca98bbf0; length=652; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=3L:complement(19708369..19709107,19709248..19710098,19710800..19711168); ID=FBpp0074720; name=trpml-PA; parent=FBgn0036904,FBtr0074952; dbxref=FlyBase:FBpp0074720,FlyBase_Annotation_IDs:CG8743-PA,GB_protein:AAF49118.1,REFSEQ:NP_649145,GB_protein:AAF49118; MD5=7cc9399738e46bec7b049f6eca98bbf0; length=652; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] CG42638 OS=Drosophila melanogaster GN=trpml PE=1 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta] type=protein; loc=3L:complement(19739785..19740523,19740664..19741514,19742216..19742584); ID=FBpp0291489; name=CG42638-PA; parent=FBgn0261361,FBtr0302283; dbxref=REFSEQ:NP_001163472,GB_protein:ACZ94743,FlyBase:FBpp0291489,FlyBase_Annotation_IDs:CG42638-PA; MD5=7cc9399738e46bec7b049f6eca98bbf0; length=652; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=3L:complement(19708369..19709107,19709248..19710098,19710800..19711168); ID=FBpp0074720; name=trpml-PA; parent=FBgn0262516,FBtr0074952; dbxref=FlyBase:FBpp0074720,FlyBase_Annotation_IDs:CG8743-PA,GB_protein:AAF49118.1,REFSEQ:NP_649145,GB_protein:AAF49118,FlyMine:FBpp0074720,modMine:FBpp0074720; MD5=7cc9399738e46bec7b049f6eca98bbf0; length=652; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] CG42638 OS=Drosophila melanogaster GN=trpml PE=2 SV=1 [UniProt_D_Melanogaster_07132012_07-13-2012_reversed.fasta] type=protein; loc=3L:complement(join(19749116..19749484,19747564..19748414,19746685..19747423)); ID=FBpp0291489; name=CG42638-PA; parent=FBgn0261361,FBtr0302283; dbxref=REFSEQ:NP_001163472,GB_protein:ACZ94743,FlyBase:FBpp0291489,FlyBase_Annotation_IDs:CG42638-PA; MD5=7cc9399738e46bec7b049f6eca98bbf0; length=652; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=3L:complement(join(19717700..19718068,19716148..19716998,19715269..19716007)); ID=FBpp0074720; name=Trpml-PA; parent=FBgn0262516,FBtr0074952; dbxref=FlyBase:FBpp0074720,FlyBase_Annotation_IDs:CG8743-PA,GB_protein:AAF49118.1,REFSEQ:NP_649145,GB_protein:AAF49118,FlyMine:FBpp0074720,modMine:FBpp0074720; MD5=7cc9399738e46bec7b049f6eca98bbf0; length=652; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=3L:complement(join(19749116..19749484,19747564..19748414,19746685..19747423)); ID=FBpp0291489; name=CG42638-PA; parent=FBgn0261361,FBtr0302283; dbxref=REFSEQ:NP_001163472,GB_protein:ACZ94743,FlyBase:FBpp0291489,FlyBase_Annotation_IDs:CG42638-PA; MD5=7cc9399738e46bec7b049f6eca98bbf0; length=652; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] type=protein; loc=3L:complement(join(19717700..19718068,19716148..19716998,19715269..19716007)); ID=FBpp0074720; name=Trpml-PA; parent=FBgn0262516,FBtr0074952; dbxref=FlyBase:FBpp0074720,FlyBase_Annotation_IDs:CG8743-PA,GB_protein:AAF49118.1,REFSEQ:NP_649145,GB_protein:AAF49118,FlyMine:FBpp0074720,modMine:FBpp0074720; MD5=7cc9399738e46bec7b049f6eca98bbf0; length=652; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] SD02261p OS=Drosophila melanogaster GN=Trpml PE=1 SV=1 [DROME.fasta.20160308] FBpp0291489 type=protein; loc=3L:complement(join(19749116..19749484,19747564..19748414,19746685..19747423)); ID=FBpp0291489; name=CG42638-PA; parent=FBgn0261361,FBtr0302283; dbxref=REFSEQ:NP_001163472,GB_protein:ACZ94743,FlyBase:FBpp0291489,FlyBase_Annotation_IDs:CG42638-PA; MD5=7cc9399738e46bec7b049f6eca98bbf0; length=652; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] FBpp0074720 type=protein; loc=3L:complement(join(19717700..19718068,19716148..19716998,19715269..19716007)); ID=FBpp0074720; name=Trpml-PA; parent=FBgn0262516,FBtr0074952; dbxref=FlyBase:FBpp0074720,FlyBase_Annotation_IDs:CG8743-PA,GB_protein:AAF49118.1,REFSEQ:NP_649145,GB_protein:AAF49118,FlyMine:FBpp0074720,modMine:FBpp0074720; MD5=7cc9399738e46bec7b049f6eca98bbf0; length=652; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=3L:complement(join(19749116..19749484,19747564..19748414,19746685..19747423)); ID=FBpp0291489; name=CG42638-PA; parent=FBgn0261361,FBtr0302283; dbxref=REFSEQ:NP_001163472,GB_protein:ACZ94743,FlyBase:FBpp0291489,FlyBase_Annotation_IDs:CG42638-PA,UniProt/TrEMBL:Q9VW35; MD5=7cc9399738e46bec7b049f6eca98bbf0; length=652; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta] type=protein; loc=3L:complement(join(19717700..19718068,19716148..19716998,19715269..19716007)); ID=FBpp0074720; name=Trpml-PA; parent=FBgn0262516,FBtr0074952; dbxref=FlyBase:FBpp0074720,FlyBase_Annotation_IDs:CG8743-PA,GB_protein:AAF49118.1,REFSEQ:NP_649145,GB_protein:AAF49118,UniProt/TrEMBL:Q9VW35,FlyMine:FBpp0074720,modMine:FBpp0074720; MD5=7cc9399738e46bec7b049f6eca98bbf0; length=652; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	652 amino acids
Gene Ontology:
Cellular Component:	lysosome [IDA]
Biological Process:	autophagy [IMP] calcium ion transport [ISS] cellular calcium ion homeostasis [IMP]
Molecular Function:	calcium channel activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQSYGPGAQT APAVKRRTDS YEAAQQQQQS PESDEEYVNT RILRRQVQLQ STPVAPVVPM  60
   61 PISAGSGTAP PSVDGREEQP EFPGSSAASY QEERMRRKLQ FFFMNPIEKW QAKRKFPYKF 120
  121 VVQIVKIFLV TMQLCLFAHS RYNHINYTGD NRFAFSHLFL RGWDSSREVE SYPPAVGPFA 180
  181 LYLKSEFFDT VQYAVNGYAN VSRSIGPYDY PTPNNTMPPL KLCLQNYREG TIFGFNESYI 240
  241 FDPHIDEVCE RLPPNVTTIG VENYLRQRDV EVNFASLVSA QLTFKIKTVN FKANGGPLSA 300
  301 PDCFRFDISI TFNNRDHDGQ MLLSLDAEAT RLKCHGATDF ISDANFDSML RSVLNIFVLL 360
  361 TCALSFALCT RALWRAYLLR CTTVNFFRSQ FGKELSFDGR LEFVNFWYIM IIFNDVLLII 420
  421 GSALKEQIEG RYLVVDQWDT CSLFLGIGNL LVWFGVLRYL GFFKTYNVVI LTLKKAAPKI 480
  481 LRFLIAALLI YAGFVFCGWL ILGPYHMKFR SLATTSECLF ALINGDDMFA TFATLSSKAT 540
  541 WLWWFCQIYL YSFISLYIYV VLSLFIAVIM DAYDTIKAYY KDGFPTTDLK AFVGTRTAED 600
  601 ISSGVFMTDL DDFDQTSFLD VVKSICCCGR CGRHQEPAQP NSGYTSLSSI MK

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: trpml-PA, CG42638-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: