Protein Overview: Dab-PA

General Information:
Name(s) found:	Dab-PA / FBpp0075077 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|66774176\|sp\|P98081.2\|DAB_DROME RecName: Full=Protein disabled [NCBI NR] gi\|24665485\|ref\|NP_524119.2\| disabled [Drosophila melanogaster] [NCBI NR] gi\|23093316\|gb\|AAF49424.2\| disabled [Drosophila melanogaster] [NCBI NR] Protein disabled OS=Drosophila melanogaster GN=Dab PE=1 SV=2 [Swiss-Prot] The gene Disabled is referred to in FlyBase by the symbol Dmel\Dab (CG9695, FBgn0000414). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:16706242..16717089. It has the cytological map location 73C1. There is experimental evidence that it has the molecular function</span>: SH2 domain binding; protein binding; SH3 domain binding. There is experimental evidence that it is involved in the biological process</span>: sevenless signaling pathway; compound eye photoreceptor development. 13 alleles are reported. No phenotypic data is available. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase] >CG9695-PA translation from_gene[CG9695 Dab FBgn0000414] seq_release:3 mol_weight=243074 cds_boundaries:(3L:16,663,092..16,672,218[+]) aa_length:2224 transcript_info:[CG9695-RA seq_release:3] gene_info:[gene symbol:Dab FBgn0000414 gene_boundaries:(3L:1 [hmr_yeast5_DM3-1_pombe.fasta] CG9695-PA [Drosophila melanogaster]gi\|24665485\|ref\|NP_524119.2\| CG9695-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas] type=protein; loc=3L:join(16707312..16707420,16708541..16708611,16708673..16709269,16709331..16709937,16710707..16710940,16711122..16714116,16714187..16714290,16714358..16715101,16715164..16715293,16715358..16716441); ID=FBpp0075077; name=Dab-PA; parent=F [fly-100309-contam.fasta] CG9695-PA [Drosophila melanogaster] [nr-271106-contam.fasta] Disabled CG9695-PA [Drosophila melanogaster] [nr-271106-contam.fasta] Protein disabled [nr-271106-contam.fasta] type=protein; loc=3L:join(16707312..16707420,16708541..16708611,16708673..16709269,16709331..16709937,16710707..16710940,16711122..16714116,16714187..16714290,16714358..16715101,16715164..16715293,16715358..16716441); ID=FBpp0075077; name=Dab-PA; parent=FBgn0000414,FBtr0075318; dbxref=FlyBase:FBpp0075077,FlyBase_Annotation_IDs:CG9695-PA,GB_protein:AAF49424.2,REFSEQ:NP_524119,GB_protein:AAF49424; MD5=90a292b6668b60240da2dfa45662ab28; length=2224; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=3L:join(16707312..16707420,16708541..16708611,16708673..16709269,16709331..16709937,16710707..16710940,16711122..16714116,16714187..16714290,16714358..16715101,16715164..16715293,16715358..16716441); ID=FBpp0075077; name=Dab-PA; parent=FBgn0000414,FBtr0075318; dbxref=FlyBase:FBpp0075077,FlyBase_Annotation_IDs:CG9695-PA,GB_protein:AAF49424.2,REFSEQ:NP_524119,GB_protein:AAF49424; MD5=90a292b6668b60240da2dfa45662ab28; length=2224; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] type=protein; loc=3L:join(16707312..16707420,16708541..16708611,16708673..16709269,16709331..16709937,16710707..16710940,16711122..16714116,16714187..16714290,16714358..16715101,16715164..16715293,16715358..16716441); ID=FBpp0075077; name=Dab-PA; parent=FBgn0000414,FBtr0075318; dbxref=FlyBase:FBpp0075077,FlyBase_Annotation_IDs:CG9695-PA,GB_protein:AAF49424.2,REFSEQ:NP_524119,GB_protein:AAF49424,FlyMine:FBpp0075077,modMine:FBpp0075077; MD5=90a292b6668b60240da2dfa45662ab28; length=2224; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta] type=protein; loc=3L:join(16714212..16714320,16715441..16715511,16715573..16716169,16716231..16716837,16717607..16717840,16718022..16721016,16721087..16721190,16721258..16722001,16722064..16722193,16722258..16723341); ID=FBpp0075077; name=Dab-PA; parent=FBgn0000414,FBtr0075318; dbxref=FlyBase:FBpp0075077,FlyBase_Annotation_IDs:CG9695-PA,GB_protein:AAF49424.2,REFSEQ:NP_524119,GB_protein:AAF49424,FlyMine:FBpp0075077,modMine:FBpp0075077; MD5=90a292b6668b60240da2dfa45662ab28; length=2224; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta] type=protein; loc=3L:join(16714212..16714320,16715441..16715511,16715573..16716169,16716231..16716837,16717607..16717840,16718022..16721016,16721087..16721190,16721258..16722001,16722064..16722193,16722258..16723341); ID=FBpp0075077; name=Dab-PA; parent=FBgn0000414,FBtr0075318; dbxref=FlyBase:FBpp0075077,FlyBase_Annotation_IDs:CG9695-PA,GB_protein:AAF49424.2,REFSEQ:NP_524119,GB_protein:AAF49424,FlyMine:FBpp0075077,modMine:FBpp0075077; MD5=90a292b6668b60240da2dfa45662ab28; length=2224; release=r6.07; species=Dmel; [fly-08202015-contam.fasta] FBpp0075077 type=protein; loc=3L:join(16714212..16714320,16715441..16715511,16715573..16716169,16716231..16716837,16717607..16717840,16718022..16721016,16721087..16721190,16721258..16722001,16722064..16722193,16722258..16723341); ID=FBpp0075077; name=Dab-PA; parent=FBgn0000414,FBtr0075318; dbxref=FlyBase:FBpp0075077,FlyBase_Annotation_IDs:CG9695-PA,GB_protein:AAF49424.2,REFSEQ:NP_524119,GB_protein:AAF49424,FlyMine:FBpp0075077,modMine:FBpp0075077; MD5=90a292b6668b60240da2dfa45662ab28; length=2224; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta] [fly-122215-dmel-6-09-contam.fasta] type=protein; loc=3L:join(16714212..16714320,16715441..16715511,16715573..16716169,16716231..16716837,16717607..16717840,16718022..16721016,16721087..16721190,16721258..16722001,16722064..16722193,16722258..16723341); ID=FBpp0075077; name=Dab-PA; parent=FBgn0000414,FBtr0075318; dbxref=FlyBase:FBpp0075077,FlyBase_Annotation_IDs:CG9695-PA,GB_protein:AAF49424.2,REFSEQ:NP_524119,GB_protein:AAF49424,UniProt/Swiss-Prot:P98081,FlyMine:FBpp0075077,modMine:FBpp0075077; MD5=90a292b6668b60240da2dfa45662ab28; length=2224; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
Organism:	Drosophila melanogaster
Length:	2224 amino acids
Gene Ontology:
Cellular Component:	cytoplasm [IDA][NAS]
Biological Process:	compound eye photoreceptor development [IMP] sevenless signaling pathway [IGI][TAS] nervous system development [NAS]
Molecular Function:	protein binding [IPI] SH3 domain binding [IPI] SH2 domain binding [IPI]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVKSLVAKLS TASSNLSLAS TFGGGSGAAE ETNYAKHRND PGRFFGDGVQ FKAKLIGILE  60
   61 VGEARGDRMC QEALQDLKMA IRAAGEHKQR ITIHVTIDGL RLRDEKTGDS LYHHPVHKIS 120
  121 FIAQDMTDSR AFGYIFGSPD SGHRFFGIKT DKAASQVVLA MRDLFQVVFE LKKKEIEMAR 180
  181 QQIQGKSLHD HSSQLASLSS LKSSGLGGMG LGHSDLASGG ISSGHALTLL GSSLSTTNGT 240
  241 SRLGVSLDVA KASGSAAKEV SPESVADLVD LEQELTSLQR GISQMERITP NEPTTSSTGG 300
  301 AGHPSLAKSA SEDDPFGDSF IYVPSYSILP PPPDSGRNRH KPPNKTPDAV TSLDAMLSPP 360
  361 PGTSSSHGSA SAGLQAADND DDNWLQELDQ QNDVFDTSKV VSSSGLGSVL AMAPLASSES 420
  421 TATPTQQLTE VAAGSGPLAD LDIGLSTALG NEEQTSTILS LDAFTDLDPL GTGRTRPYVD 480
  481 KKYFFQELKN PPKKLLKELS SGSQAGLGLG LSLGQLDGLF PEDSTTISTT TTTATNITAG 540
  541 NPQQNSANTL TSTASTAASL GQLLSTVALN PDPLPAPISI PTSISHSITP SAELKLLLGH 600
  601 VTNPPNPTGH YYTTEPPTLN SLENPHPPAD PVLLPRDTDP FSPTRKKSDP DPFQESDLFA 660
  661 KLDAFEFEAP PAVPAPSIPN LATETKANVF NGPLQVQLPP EKELQLQQPP STVRNRPTAS 720
  721 VSALPSGGAL DVISSISNKK MPHLFGQARS FGKSGSDIGS SVNMRRLQES DSLSETEAAP 780
  781 EPPPRPDSTP YSEPPPLPPK KQFSDLVIRP SPANTTQPPT SGRYEYLNSN VTARRTASSV 840
  841 DAPPIPLPSR RVGRSDGCFP GPGRPRKPGH TEDDYLAPLG APPPLLPPPS QGSSARARPQ 900
  901 RQASLGRPQD IYENKAEILQ AQAQAQAQAP EVAPSSNTLA PDITLTQLLT LGMDDLAIKL 960
  961 NVPASKLSTM TLVQLTAYLS EYLSSEKSQV HSQERRSSPA NTAPAPASTA AVFKVNFDQQ1020
 1021 TSFVAKFDDT FGEDEPVMPS GSSDSTFVAN FANFNDAPTP VPTVSPVVAT VPSADRYAVF1080
 1081 REIIDQELQQ QQQETDLMGD LTPPPVDETQ AKEISEGLEV NNVGAELPID ALDVKPAPKI1140
 1141 DTKITEVVAQ AKDRYAALRD IILVENLFDK PAIATDTQPE KEKDLLQDFP EFSDEFNEDH1200
 1201 DLRQIMDHQN VQTHARDRHG LVDSRGFPTE PSSSALTVGD YDEDEDADAG GESSLDSNEK1260
 1261 DAEPVSGQDQ YEKLSTSTQQ LDAAAPALED VQQLQQQSLP PKQDQKFLSI LTAPGGGTKD1320
 1321 DIEIDELMHR AISNLSLDSR DRVSPATSSA APSRGAPGLH TPSQFNDVST SPIPLQKPGM1380
 1381 GPSPVPSQLS AVSQLIDTAT KQMMGDKDRE KQSWATFDSP KAKGKARLTL PPPPPPASNT1440
 1441 SQPDTVESPC SSDPRDDGWS KQQRRWAKKE RQQTSSSSRD LSPWDDETPE YLKRRQLAAA1500
 1501 QMAHPHQPPM QAPPQHTDRH GYYMRHARRM NSCDEDYDYD GEFVARRDQP QHQQQQRKFK1560
 1561 HGLSRSRDNF ELESPSWYHH PAHHTWSPQE IEQVRVRSFD RTAYERSSYG PPPPIYDKRG1620
 1621 QLRGKYRGDH RDRERERDRD REYRDYARPS YDFDYENVYE ERGGRSPLAY KPGRGGGDYL1680
 1681 YDRERDRDRE RDRKSFDRES LESYESATRR RRSFGSGNDV YGSLDSRDDY RGDRERDRER1740
 1741 DREQMKTRSL RKPTTTSGKL RISGDIDYEQ DSEQDFQQRS GVRSLQRPNQ LGGDVVLPSN1800
 1801 AVVGPQRLRK SSGSSPWDGE EPALPGQKSW KRPASAAETE RRLAESRRAV ALGQTPSDGE1860
 1861 KERRFRKKTR ARSAKDLATV GAPSASTSAP SRSSYGRGIR DNYDYICPGQ RNDDDDDDDE1920
 1921 DYVDDEPPTD EDKFERLNRR RHEMHQRMLE SERRQMERHQ PPSLAKLPGQ NRTRGVVANS1980
 1981 DYGFVDSYEQ TPTPTPRSNA SSTGPGGLMM SGGESSAGVT SSKFNFDDGF ESDFNQSSPP2040
 2041 PAPAGTASSC NSTPAGPVSA NANNGGSKSL FRFSNDFSDR EKREQFEMDT PPTSTPPITQ2100
 2101 KLRFDDNVKV SQFDDAAFED DFAKASFDFE KEQAGSATAG AGGSGAMSRK QNMRTSKLQQ2160
 2161 RQELIKKSES VNIFAKKQED PFEDDEFFKS PDQEQAMDQH NDDTEGGKFQ WSEDANFAKF2220
 2221 DENM

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein Overview: Dab-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: