Protein Overview: AGO2-PB

General Information:
Name(s) found:	AGO2-PB / FBpp0075312 [FlyBase]
Description(s) found: Found 20 descriptions. SHOW ALL	The gene Argonaute 2 is referred to in FlyBase by the symbol Dmel\AGO2 (CG7439, FBgn0087035). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:15547217..15554146. It has the cytological map location 71C3-71E5. There is experimental evidence that it has the molecular function</span>: protein binding; endoribonuclease activity; siRNA binding. There is experimental evidence for 14 unique biological process</span> terms, many of which group under: regulation of metabolic process; anatomical structure development; gene silencing by RNA; regulation of biological process; transport; programmed cell death; cellular localization; production of small RNA involved in gene silencing by RNA; cellular macromolecular complex subunit organization; gene silencing by miRNA; embryonic pattern specification; gland morphogenesis; syncytial nuclear migration; response to virus; microtubule-based movement. 32 alleles are reported. The phenotypes of these alleles are annotated with: embryonic/first instar larval cuticle; pole cell; condensed chromosome; pole bud. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	1214 amino acids
Gene Ontology:
Cellular Component:	RISC-loading complex [IDA] RNA-induced silencing complex [IDA][TAS]
Biological Process:	[NOT]gene silencing by miRNA [IMP] siRNA loading onto RISC involved in RNA interference [IDA][IMP] syncytial nuclear migration [IMP] pole cell formation [IMP] segment polarity determination [IGI] salivary gland cell autophagic cell death [IEP] translational initiation [ISS] cellularization [IMP] autophagic cell death [IEP] defense response to virus [IMP] production of siRNA involved in RNA interference [IDA] RNA interference [IDA][IMP][NAS][TAS] lipid particle transport along microtubule [IMP] negative regulation of viral genome replication [IMP] dsRNA transport [IMP] targeting of mRNA for destruction involved in RNA interference [TAS]
Molecular Function:	translation initiation factor activity [ISS] protein binding [IPI] siRNA binding [IDA] endoribonuclease activity [IDA]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGKKDKNKKG GQDSAAAPQP QQQQKQQQQR QQQPQQLQQP QQLQQPQQLQ QPQQQQQQQP  60
   61 HQQQQQSSRQ QPSTSSGGSR ASGFQQGGQQ QKSQDAEGWT AQKKQGKQQV QGWTKQGQQG 120
  121 GHQQGRQGQD GGYQQRPPGQ QQGGHQQGRQ GQEGGYQQRP PGQQQGGHQQ GRQGQEGGYQ 180
  181 QRPSGQQQGG HQQGRQGQEG GYQQRPPGQQ QGGHQQGRQG QEGGYQQRPS GQQQGGHQQG 240
  241 RQGQEGGYQQ RPPGQQQGGH QQGRQGQEGG YQQRPPGQQQ GGHEQGRQGQ EGGYQQRPSG 300
  301 QQQGGHQQGR QGQEGGYQQR PSGQQQGGHQ QGRQGQEGGY QQRPSGQQQG GHQQGRQGQE 360
  361 GGYQQRPPGQ QPNQTQSQGQ YQSRGPPQQQ QAAPLPLPPQ PAGSIKRGTI GKPGQVGINY 420
  421 LDLDLSKMPS VAYHYDVKIM PERPKKFYRQ AFEQFRVDQL GGAVLAYDGK ASCYSVDKLP 480
  481 LNSQNPEVTV TDRNGRTLRY TIEIKETGDS TIDLKSLTTY MNDRIFDKPM RAMQCVEVVL 540
  541 ASPCHNKAIR VGRSFFKMSD PNNRHELDDG YEALVGLYQA FMLGDRPFLN VDISHKSFPI 600
  601 SMPMIEYLER FSLKAKINNT TNLDYSRRFL EPFLRGINVV YTPPQSFQSA PRVYRVNGLS 660
  661 RAPASSETFE HDGKKVTIAS YFHSRNYPLK FPQLHCLNVG SSIKSILLPI ELCSIEEGQA 720
  721 LNRKDGATQV ANMIKYAATS TNVRKRKIMN LLQYFQHNLD PTISRFGIRI ANDFIVVSTR 780
  781 VLSPPQVEYH SKRFTMVKNG SWRMDGMKFL EPKPKAHKCA VLYCDPRSGR KMNYTQLNDF 840
  841 GNLIISQGKA VNISLDSDVT YRPFTDDERS LDTIFADLKR SQHDLAIVII PQFRISYDTI 900
  901 KQKAELQHGI LTQCIKQFTV ERKCNNQTIG NILLKINSKL NGINHKIKDD PRLPMMKNTM 960
  961 YIGADVTHPS PDQREIPSVV GVAASHDPYG ASYNMQYRLQ RGALEEIEDM FSITLEHLRV1020
 1021 YKEYRNAYPD HIIYYRDGVS DGQFPKIKNE ELRCIKQACD KVGCKPKICC VIVVKRHHTR1080
 1081 FFPSGDVTTS NKFNNVDPGT VVDRTIVHPN EMQFFMVSHQ AIQGTAKPTR YNVIENTGNL1140
 1141 DIDLLQQLTY NLCHMFPRCN RSVSYPAPAY LAHLVAARGR VYLTGTNRFL DLKKEYAKRT1200
 1201 IVPEFMKKNP MYFV

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: AGO2-PB

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: