Protein Overview: Gap1-PA, Gap1-PB

General Information:
Name(s) found:	Gap1-PB / FBpp0076097 [FlyBase] Gap1-PA / FBpp0076096 [FlyBase]
Description(s) found: Found 36 descriptions. SHOW ALL	The gene GTPase-activating protein 1 is referred to in FlyBase by the symbol Dmel\Gap1 (CG6721, FBgn0004390). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:9832195..9848379. It has the cytological map location 67C10-67C11. There is experimental evidence that it has the molecular function</span>: Ras GTPase activator activity. There is experimental evidence that it is involved in the biological process</span>: Ras protein signal transduction; female meiosis chromosome segregation; positive regulation of R7 cell differentiation; tracheal outgrowth, open tracheal system; mitosis; imaginal disc-derived wing morphogenesis; sister chromatid cohesion. 60 alleles are reported. The phenotypes of these alleles are annotated with 22 unique terms, many of which group under: peripheral nervous system; external compound sense organ; adult segment; nervous system; adult mesothoracic segment; compound cell cluster organ; nuclear part; blastoderm embryo; rhabdomere; egg; embryonic heart; gastrula embryo. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase] The gene GTPase-activating protein 1 is referred to in FlyBase by the symbol Dmel\Gap1 (CG6721, FBgn0004390). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:9832195..9848379. It has the cytological map location 67C10-67C11. There is experimental evidence that it has the molecular function</span>: Ras GTPase activator activity. There is experimental evidence that it is involved in the biological process</span>: Ras protein signal transduction; female meiosis chromosome segregation; positive regulation of R7 cell differentiation; tracheal outgrowth, open tracheal system; mitosis; imaginal disc-derived wing morphogenesis; sister chromatid cohesion. 60 alleles are reported. The phenotypes of these alleles are annotated with 22 unique terms, many of which group under: peripheral nervous system; external compound sense organ; adult segment; nervous system; adult mesothoracic segment; compound cell cluster organ; nuclear part; blastoderm embryo; rhabdomere; egg; embryonic heart; gastrula embryo. It has 2 annotated transcripts and 2 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	1163 amino acids
Gene Ontology:
Cellular Component:	plasma membrane [IDA] intracellular [IEA]
Biological Process:	torso signaling pathway [NAS] sister chromatid cohesion [IMP] negative regulation of Ras protein signal transduction [NAS] anterior/posterior axis specification, embryo [TAS] regulation of small GTPase mediated signal transduction [IEA] imaginal disc-derived wing morphogenesis [IMP] Ras protein signal transduction [IMP][NAS] mitosis [IMP] female meiosis chromosome segregation [IMP] tracheal outgrowth, open tracheal system [IMP] positive regulation of R7 cell differentiation [IGI]
Molecular Function:	Ras GTPase activator activity [IMP][ISS][NAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLLKKKRYMF DERDDNNINS PVAVEPSSNN NKMADTREVR IEEQLKVKIG EAKNLSSRNA  60
   61 ANTSCSTQGT RDVYCTIALD QEEICRTPTI ERTLTPFFGE EHQFKIPRRF RYLTIYLWDR 120
  121 DMKQDKPIGK IAIKREELHM YNHKDHWFSL RPVDQDSEVQ GMVNVEVAFT EAQQTQSLSE 180
  181 GIDLGQHTLR HHQNLPHHSH QQRAHLNDYK ENSELSNIQR ASAAAASSSS AAMTLKTRAA 240
  241 GLFGHVHHPP SQTQHFPIIN TTSTSSDQLS NWKSHGRFVG VTIKVPACVD LAKKQGTCDP 300
  301 FVVCTAHYSN KHQVTRRTKQ RKKTVDPEFD EAMYFDLHID ADAGSTNTTG SNKSAGSLES 360
  361 SANKGYSIYP VGGADLVEIV VSVWHDAHGA MSDKVFLGEV RLPMLNKQEQ QAVNPSAWYY 420
  421 LQPRSMTHSS RSLNATPRSC ATPPGTRLSV DSTIGSLRLN LNYTADHVFP LATYDDLMNL 480
  481 LLESVDQRPI TVSAVSILGE LVSGKTEVAQ PLVRLFTHTE RIAPIIKALA DHEISHLTDP 540
  541 TTIFRGNTLV SKMMDEAMRL SGLHYLHQTL RPVLSQIVAE KKPCEIDPSK IKDRSAVDTN 600
  601 LHNLQDYVER VFEAITKSAD RCPKVLCQIF HDLRECAGEH FPSNREVRYS VVSGFIFLRF 660
  661 FAPAILGPKL FDLTTERLDA QTSRTLTLIS KTIQSLGNLV SSRSSQQTCK EEFTVELYKK 720
  721 FCTEQHVDAV KHFLEVISTP SHASSSVHPA AAAATPLEPV LLKEGLMTKY PTSRKRFGRQ 780
  781 FKQRHFRLTT HSLSYAKSKG KQPICDIPLQ EIASVEQLKD KSFKMQNCFK IVHNDRSLIV 840
  841 QTTNCVEERE WFDLLHKICL MNSIRMQYFH PSAFVSGFYS CCGRSDENSP GCKKVLDKTM 900
  901 DYFQMDLVTA LDPALDLQRI HTLIMSNMSV LESLLDPLTY HQSLSQTQHQ QHNPLVPLAT 960
  961 DLQKHSPQAF AEFKRTIEKL REKAYAIDRD HRDYKQGITR QLKYGSRQAP IGDDNYWHMM1020
 1021 RAAGQLNQQH HQQQQHQQQQ QQQQQQQLQQ FQPQPVLPQM QNVRAYPYQP ATSNMNAYCL1080
 1081 HNMQYQQQRL PFHQQQQQHH QQLQQQQSQF QPLRSHQLQR HNNNLNNNNC GNGSSSSPSS1140
 1141 TTSSVVAAPP STTSSSQPAP PIY

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: Gap1-PA, Gap1-PB

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: