Protein Overview: nwk-PA

General Information:
Name(s) found:	nwk-PA / FBpp0076259 [FlyBase]
Description(s) found: SHOW ONLY BEST	gi\|24661405\|ref\|NP_648290.1\| nervous wreck [Drosophila melanogaster] [NCBI NR] gi\|23093865\|gb\|AAF50313.2\| nervous wreck [Drosophila melanogaster] [NCBI NR] The gene nervous wreck is referred to in FlyBase by the symbol Dmel\nwk (CG4684, FBgn0035966). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:9131777..9134677. It has the cytological map location 67A1. Based on sequence similarity, it is predicted to have molecular function</span>: SH3/SH2 adaptor activity. There is experimental evidence that it is involved in the biological process</span>: negative regulation of synaptic growth at neuromuscular junction; neuromuscular synaptic transmission. 7 alleles are reported. The phenotype of these alleles is annotated with: bouton. It has one annotated transcript and one annotated polypeptide. [FlyBase] >CG4684-PA translation from_gene[CG4684 CG4684 FBgn0035966] seq_release:3 mol_weight=89593 cds_boundaries:(3L:9,097,387..9,100,283[+]) aa_length:795 transcript_info:[CG4684-RA seq_release:3] gene_info:[gene symbol:CG4684 FBgn0035966 gene_boundaries:(3L [hmr_yeast5_DM3-1_pombe.fasta] (Q9VSU8) CG4684 protein [DrosMelano7227.FASTAC.txt] CG4684-PA [Drosophila melanogaster]gi\|24661405\|ref\|NP_648290.1\| CG4684-PA [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas] type=protein; loc=3L:join(9131777..9131797,9131873..9132102,9132193..9132720,9133006..9133888,9133951..9134676); ID=FBpp0076259; name=nwk-PA; parent=FBgn0035966,FBtr0076532; dbxref=FlyBase:FBpp0076259,FlyBase_Annotation_IDs:CG4684-PA,GB_protein:AAF50313.2 [fly-100309-contam.fasta] CG4684-PA [Drosophila melanogaster] [nr-271106-contam.fasta] nervous wreck CG4684-PA [Drosophila melanogaster] [nr-271106-contam.fasta] type=protein; loc=3L:join(9131777..9131797,9131873..9132102,9132193..9132720,9133006..9133888,9133951..9134676); ID=FBpp0076259; name=nwk-PA; parent=FBgn0035966,FBtr0076532; dbxref=FlyBase:FBpp0076259,FlyBase_Annotation_IDs:CG4684-PA,GB_protein:AAF50313.2,REFSEQ:NP_648290,GB_protein:AAF50313; MD5=29e095c300bcad7220c54e224ea755e7; length=795; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta] type=protein; loc=3L:join(9131777..9131797,9131873..9132102,9132193..9132720,9133006..9133888,9133951..9134676); ID=FBpp0076259; name=nwk-PA; parent=FBgn0035966,FBtr0076532; dbxref=FlyBase:FBpp0076259,FlyBase_Annotation_IDs:CG4684-PA,GB_protein:AAF50313.2,REFSEQ:NP_648290,GB_protein:AAF50313; MD5=29e095c300bcad7220c54e224ea755e7; length=795; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta] Nervous wreck OS=Drosophila melanogaster GN=nwk PE=1 SV=2 [UniProt_drosophila_07-01-2011_reversed.fasta]
Organism:	Drosophila melanogaster
Length:	795 amino acids
Gene Ontology:
Cellular Component:	NONE FOUND
Biological Process:	neuromuscular synaptic transmission [IMP] negative regulation of synaptic growth at neuromuscular junction [IMP]
Molecular Function:	SH3/SH2 adaptor activity [ISS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MQPPPRKGNY VKFLKNLHTE QVAKLQLKNQ HECDLLEDIR QFTIKRSAVE KSYSESLLKI  60
   61 SSQYLNKKIP NIPDIKMEGM EERWNMWSVW RTVLEENEKL ARARLAAIEV FQQQIADEAK 120
  121 VLRDYKLAIA KRSLAGIVNV QKELHLSVGD VDKTKKSYFD EEHCAHDVRD KARDIEEKLK 180
  181 KKKGSFFQSI TSLQKNSARV TSRKELLEEK SSGARNDYVL SLAAANAHQN RYFTVDLQTT 240
  241 MTTMENYVFE RVAEYLMLMG RTELLTCSAT QNSFGKIRDQ AQQLTREYNL QCCYLFYPVL 300
  301 KQHIQYDFEA CDNDPVRKVT AEHESAAETL TKEAKNLAGR VVKENASIRE NAKKLALCQS 360
  361 LRDSGQRTDP NDPNGPDLDT KIEEFRDQIR RSETEKTKAE ACLQCLRDGG INVDEWVQEA 420
  421 ENMGVQELTR SASSISMRTD ASGQGENPSS DSFYDSDKEE TQAAAQTKPK QEQQLSRDRT 480
  481 FSDSEDEPEV RPSAAAASSA AAASSSMMAS SAGGWDDPTE VNWGAGEEED DKDEPIVPEP 540
  541 KEAIFKCTAL YSYTAQNPDE LTIVENEQLE VVGEGDGDGW LRARNYRGEE GYVPHNYLDI 600
  601 DQETAGSAFN GTSGNQLRSQ ISFSSVDYTV DNEDQTVDSM QSPDQVSVIM APQKRVKSDV 660
  661 EWCIALYDYD ATAEDELTFE EGDKIKIITK TAHGVDDGWW EGELDGKFGN FPSLVVEECD 720
  721 EMGEPLSEGG DESPPPTAAP TFALPPAPAL PPEYAHELEL ELTEDMFGSQ DTAGKHVETL 780
  781 QIYNIYIYIY IYIYI

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

SHOWING SINGLE HITS. [ Hide Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: nwk-PA

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: