Protein Overview: pbl-PC

General Information:
Name(s) found:	pbl-PC / FBpp0076488 [FlyBase]
Description(s) found: Found 19 descriptions. SHOW ALL	The gene pebble is referred to in FlyBase by the symbol Dmel\pbl (CG8114, FBgn0003041). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:7889214..7905051. It has the cytological map location 66A18-66A19. Based on sequence similarity, it is predicted to have molecular function</span>: guanyl-nucleotide exchange factor activity. There is experimental evidence for 13 unique biological process</span> terms, many of which group under: anatomical structure development; cell cycle; cell division; cell cycle process; organ morphogenesis; cellular component movement; regulation of developmental process; regulation of cell morphogenesis; cell adhesion; regulation of neurogenesis; establishment of protein localization. 40 alleles are reported. The phenotypes of these alleles are annotated with 22 unique terms, many of which group under: primordium; peripheral nervous system; external compound sense organ; nervous system; germ layer; adult segment; cytoplasmic part; adult mesothoracic segment; embryonic nervous system; actomyosin contractile ring; spindle; rhabdomere; neuroblast NB6-4 of abdomen; cell cycle; late extended germ band embryo. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	782 amino acids
Gene Ontology:
Cellular Component:	nucleus [NAS] intracellular [IEA]
Biological Process:	regulation of cell shape [IMP] regulation of Rho protein signal transduction [IEA] cytokinesis, actomyosin contractile ring assembly [IMP][TAS] mesodermal cell migration [IMP] cytokinesis after meiosis I [IMP] Malpighian tubule morphogenesis [IMP] nervous system development [IMP] cytokinesis [IMP][NAS][TAS] peripheral nervous system development [TAS] cell adhesion [IMP] cytokinesis after meiosis II [IMP] establishment of protein localization [IMP] spindle assembly [IMP] regulation of axonogenesis [IGI] mesoderm migration [IMP]
Molecular Function:	guanyl-nucleotide exchange factor activity [ISS][NAS] Rho guanyl-nucleotide exchange factor activity [IEA][TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MESGEKTAKG RWKLILGPPA LKYAAEMKQT LGQNSRPIYN YAMRGVVTCF TGIRKKDELT  60
   61 KLVNLIHSMG GCIKKDLNTK TTHLICNHSG GEKYQYAKTF RLTVVRPAWV FAAWADRNSL 120
  121 EFDATQENFT KTHRLKAFEG QKICFFGFPV EEHQHMVDVL LENGGVCAEL DDPECSHVVV 180
  181 DEHTTLTKPE PKNNHTHILK SDWFWYTIQN GYANEMDYLF GDYLDSITNT PNTDRRDSLP 240
  241 ISFNKRKRKR FSQRIQLEGT PLGSGKRRSS VSDAGLLSVS NSLFDCTTSP DKLESDKLLH 300
  301 AEPEASDATP AKKSMRFNHF MDFYTTESNY VGILDTILNL FKNKLEELAE TNDPLLNKSE 360
  361 IKTIFGNFLP IHEVHQSMLE HLRKLHANWR EDCLIGDIII QHRDELIKAY PPYVNFFEQM 420
  421 KEQLQYCDRE YPRFHAFLKI NQTKPECGRQ GLQDLMIRPV QRLPSISLLL NDILKHTTSG 480
  481 NADHGRLEEA LKAIKQVTLH INEDKRRTES RMAIFDIFND IEGCPAHLVS SNRSFILKCE 540
  541 VNELSDSLSG RGDSLVLYLF SDSIELCKRR SKGFNTAKSP STAKTHKHLK LISLNTIRLV 600
  601 IDISDSPRAF GLLLRGDKEK LYTFTISDEE TDKSVYVKKL CNQIAAHTCR TDADKLLICR 660
  661 TSQELEVDIS DVNVSTLSKA FKLAAKTRLK VGRAFSFNKT PNKLKRAVST MMTSPFGSTN 720
  721 SLTPASQLAQ MRLASCTNIN EVDDEDCASM RSSSPSTQSE MLVVPPLSVQ PTRKNKAVVG 780
  781 RI

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: pbl-PC

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: