Protein Overview: pbl-PB

General Information:
Name(s) found:	pbl-PB / FBpp0076487 [FlyBase]
Description(s) found: Found 19 descriptions. SHOW ALL	The gene pebble is referred to in FlyBase by the symbol Dmel\pbl (CG8114, FBgn0003041). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:7889214..7905051. It has the cytological map location 66A18-66A19. Based on sequence similarity, it is predicted to have molecular function</span>: guanyl-nucleotide exchange factor activity. There is experimental evidence for 13 unique biological process</span> terms, many of which group under: anatomical structure development; cell cycle; cell division; cell cycle process; organ morphogenesis; cellular component movement; regulation of developmental process; regulation of cell morphogenesis; cell adhesion; regulation of neurogenesis; establishment of protein localization. 40 alleles are reported. The phenotypes of these alleles are annotated with 22 unique terms, many of which group under: primordium; peripheral nervous system; external compound sense organ; nervous system; germ layer; adult segment; cytoplasmic part; adult mesothoracic segment; embryonic nervous system; actomyosin contractile ring; spindle; rhabdomere; neuroblast NB6-4 of abdomen; cell cycle; late extended germ band embryo. It has 5 annotated transcripts and 5 annotated polypeptides. [FlyBase]
Organism:	Drosophila melanogaster
Length:	1311 amino acids
Gene Ontology:
Cellular Component:	nucleus [NAS] intracellular [IEA]
Biological Process:	regulation of cell shape [IMP] regulation of Rho protein signal transduction [IEA] cytokinesis, actomyosin contractile ring assembly [IMP][TAS] mesodermal cell migration [IMP] cytokinesis after meiosis I [IMP] Malpighian tubule morphogenesis [IMP] nervous system development [IMP] cytokinesis [IMP][NAS][TAS] peripheral nervous system development [TAS] cell adhesion [IMP] cytokinesis after meiosis II [IMP] establishment of protein localization [IMP] spindle assembly [IMP] regulation of axonogenesis [IGI] mesoderm migration [IMP]
Molecular Function:	guanyl-nucleotide exchange factor activity [ISS][NAS] Rho guanyl-nucleotide exchange factor activity [IEA][TAS]

Sequence:

Sequence:
[PDR BLAST]
[ProtParam]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEMETIEEQS KCEMSITTLP TRICLVGGVG QDADTLQAAE SFGLPIVTSD TGLDILGESS  60
   61 DWRTFYVLDD FEGASFEAIH KQKECILGPP ALKYAAEMKQ TLGQNSRPIY NYAMRGVVTC 120
  121 FTGIRKKDEL TKLVNLIHSM GGCIKKDLNT KTTHLICNHS GGEKYQYAKT FRLTVVRPAW 180
  181 VFAAWADRNS LEFDATQENF TKTHRLKAFE GQKICFFGFP VEEHQHMVDV LLENGGVCAE 240
  241 LDDPECSHVV MPNTGAVFTS TSTSTDTNPS TLINPPESQV PGSSSASQAG EEEQRKAEHL 300
  301 EQAEIKKMEY SHAETDNGMS LDIDQEQKEN QGIEDEDDIH FDERLFVEAA DIINHGEDQL 360
  361 PESDEEDLEE EQKPKVEEVL KEQEVEEDVQ ASTPKTSKIR TSLKAATPLS SPEMDGIALD 420
  421 FESTTQNISP ILKAIDECDL ETDDLPPSEN DLKRKRESFD NVSLMSVDSF ALPASTKKPK 480
  481 LIRTGSISRT LRRSVSFVAE PLMKTLRPRR SSVADASSFV GSEAADNSIC SLASSINLTL 540
  541 NDSIRKPVKE KLRSFCGRIT RSSSRRHDRG VDGTPECTTL LDSGFKTPKA PKLRSTATPK 600
  601 TAKRLFGPVS GVVSALTLTN PSTPTPNPNP NTNCTATLDV NDTSIHTFAF CAAAVTPAMP 660
  661 PSSSSSSSSP ILSTSIAVHS SVQVIKSPEE STTRRNSPAP IEEPMAMVVD EHTTLTKPEP 720
  721 KNNHTHILKS DWFWYTIQNG YANEMDYLFG DYLDSITNTP NTDRRDSLPI SFNKRKRKRF 780
  781 SQRIQLEGTP LGSGKRRSSV SDAGLLSVSN SLFDCTTSPD KLESDKLLHA EPEASDATPA 840
  841 KKSMRFNHFM DFYTTESNYV GILDTILNLF KNKLEELAET NDPLLNKSEI KTIFGNFLPI 900
  901 HEVHQSMLEH LRKLHANWRE DCLIGDIIIQ HRDELIKAYP PYVNFFEQMK EQLQYCDREY 960
  961 PRFHAFLKIN QTKPECGRQG LQDLMIRPVQ RLPSISLLLN DILKHTTSGN ADHGRLEEAL1020
 1021 KAIKQVTLHI NEDKRRTESR MAIFDIFNDI EGCPAHLVSS NRSFILKCEV NELSDSLSGR1080
 1081 GDSLVLYLFS DSIELCKRRS KGFNTAKSPS TAKTHKHLKL ISLNTIRLVI DISDSPRAFG1140
 1141 LLLRGDKEKL YTFTISDEET DKSVYVKKLC NQIAAHTCRT DADKLLICRT SQELEVDISD1200
 1201 VNVSTLSKAF KLAAKTRLKV GRAFSFNKTP NKLKRAVSTM MTSPFGSTNS LTPASQLAQM1260
 1261 RLASCTNINE VDDEDCASMR SSSPSTQSEM LVVPPLSVQP TRKNKAVVGR I

Protein Complex Data

No complex found for this protein.

Mass Spectrometry Data

No mass spectrometry results found for this protein.

Yeast Two-Hybrid Data

The following interactions contain this protein:

NOT SHOWING SINGLE HITS. [ Show Single Hits ]

[View our yeast two-hybrid interpretation guidelines.]

No yeast two-hybrid interactions found for this protein.

Protein predicted to be:	GLOBULAR (No transmembrane regions or signal peptide)
Confidence of classification:	0.99

Protein Overview: pbl-PB

Protein Complex Data

Mass Spectrometry Data

Yeast Two-Hybrid Data

Microscopy / Localization Data

Protein Structure Data

Philius Transmembrane Prediction: