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Protein Overview: eIF4E-4-PA

General Information:
Name(s) found: eIF4E-4-PA / FBpp0076672 [FlyBase]
Description(s) found:
Found 22 descriptions.
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  • The gene eIF4E-4 is referred to in FlyBase by the symbol Dmel\eIF4E-4 (CG10124, FBgn0035709). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 3L:6657323..6658741. It has the cytological map location 65C1. Based on sequence similarity, it is predicted to have molecular function</span>: RNA cap binding; translation initiation factor activity. Based on sequence similarity, it is predicted to be involved in the biological process</span>: translational initiation. 2 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 229 amino acids

    Gene Ontology:
    Cellular Component: eukaryotic translation initiation factor 4F complex [ISS]
    Biological Process: translational initiation [ISS]
    Molecular Function: translation initiation factor activity [ISS]
    RNA binding [IEA]
    RNA cap binding [ISS]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLTTQQTEFK MMDNGTETLA DSPSSSSEDL KTLSDMDIRK PVTEIVDLRL KHPLENTWTL  60
   61 WYLENDRSKN WEDMQNEITS FDMVEDFWSL YNHIKQPSEI RVGSDYSLFK KGIQPMWEDD 120
  121 ANKFGGRWVI NMGRGSKAEL DKLWLDVLLI LIGEAFENTE EVCGAVINLR GKSNKISIWT 180
  181 ANGHNELAVM EIGLKLRDLL VLPPHQLQYQ LHKDTMCKQG SVIKAVYCV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..229] PSI-BLAST 75.0 Translation initiation factor eIF4e

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • translation initiation factor activity
    		•  12.6022960879923 bayes_pls_golite062009
  • RNA cap binding
    		•  8.70938037002519 bayes_pls_golite062009
  • translation factor activity, nucleic acid binding
    		•  7.91586572659635 bayes_pls_golite062009
  • translation regulator activity
    		•  7.87578736455963 bayes_pls_golite062009
  • RNA binding
    		•  4.73187299490341 bayes_pls_golite062009
  • nucleic acid binding
    		•  3.46353214508261 bayes_pls_golite062009
  • binding
    		•  2.88787215275737 bayes_pls_golite062009
  • RNA 7-methylguanosine cap binding
    		•  0.544036568660606 bayes_pls_golite062009
  • protein binding
    		•  0.153677987194444 bayes_pls_golite062009


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.99

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle