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Protein Overview: Eps-15-PA

General Information:
Name(s) found: Eps-15-PA / FBpp0072340 [FlyBase]
Description(s) found:
Found 19 descriptions.
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  • The gene Epidermal growth factor receptor pathway substrate clone 15 is referred to in FlyBase by the symbol Dmel\Eps-15 (CG16932, FBgn0035060). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:20655837..20662788. It has the cytological map location 60E1. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: calcium ion binding. There is experimental evidence that it is involved in the biological process</span>: synaptic vesicle endocytosis; vesicle-mediated transport; regulation of synaptic growth at neuromuscular junction. 15 alleles are reported. The phenotypes of these alleles are annotated with: bouton; larval neuromuscular junction. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 1253 amino acids

    Gene Ontology:
    Cellular Component: synaptic vesicle [IDA]
    Biological Process: vesicle-mediated transport [IMP]
    synaptic vesicle endocytosis [IMP][TAS]
    regulation of synaptic growth at neuromuscular junction [IMP]
    receptor-mediated endocytosis [NAS]
    neurotransmitter secretion [NAS]
    Molecular Function: calcium ion binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNVDFARVCG KHIGVYEAYY KLIDPKGTGA IEAMTAAKFL KKSGLSDVVL SRIWDLSDPS  60
   61 GKGFLDKPGF FVALKLVSLS QAGQVASMAN IYLDIANPPK LGELPKTMPS RIQTVPVASG 120
  121 GVANGDWSIG VIDRLKYEQL FESLHPSNGM LPGNKVKGVL MDSKLPMSIL GTIWDLADQD 180
  181 KDGNLDMHEF VVAMHLVYQT LQKRTIPSVL PPELRKPGGA GPPPKPAMPP PPAGAAMPRA 240
  241 PSGEGFGDGG FVANFPKDIA PPAAIPPLPV AVPPMTRIPP VGAVSSQPLI QTDPLIPIGA 300
  301 PVMANADWVV TPADLKRFEE IFRQSDLDKD GLVSGLEVKD IFIKSGIPQR SLADIWALCD 360
  361 TNQSGKLTVE QFALAMWFVE RKQRGVDPPH VLNANMVPPS MRATVAGVDL QPQEVKPTYS 420
  421 NPELEMISKE IEELARERRV LETEIAQKEA DVRIKNGEVR SLQSELDTLT ATLKQLENQR 480
  481 GEAQKRLDDL QAQVSHNTAV LANVSLDISR TNEQVTKIRD QCHMQEVTIN EQEGELNAKR 540
  541 SELQKLKDEE ASLQKEYDSN NRELSKLTNH LQATQLQISS VRSMVTQLLE TQRQMTDALL 600
  601 ICRAAMENQN AELVSEYQLK IEPDFDEARK TLTKEVQLPK DDPFEENNSG AANQATNGFG 660
  661 SDPFSGQPVN KPAISTGFDD SFNMSSGFDS GFDAFGQSGA GSAFGQTQRD PFGSDAFAAN 720
  721 KSNAITPEPG KDDFGSDPFA ALHAPTGQGQ VLSPNAQKSG PPPRPESPSP ALPPKKSKVP 780
  781 PPRPAPPRAA QPTGGFGSGG GGGFADFDDF DNKLHHIPSA PSPSATALSP LPPTLPAPIP 840
  841 VVSGSSLLDS FTLFDDPGQI HKQAASTPNP TPITVPTVHT LLQTSLSTPA APSPALASLS 900
  901 TSGSGSVAGA GADLPSSVTI TTAPSLNNQH LSRSNTPLQN QRTADVKLET KAVVSVFDAF 960
  961 GEIGTRKAPT PSLITGPTDF KDDPFKDYRY EDPFSIKDPF AEEGEEELSE GKGADHKRNF1020
 1021 AEDFSSGDEI GSAAKTLSNI VNNNSIKPKA ATPLNNDLLQ QFDAFNLNSS PAPSHHSGTS1080
 1081 YHSNSKPSHD SQTALDAFAD FDDFAATLAT TGGSGAATTA TTTGNTKLNN SFFDAFNDNF1140
 1141 SVIQSSSVPT GVVRPNDQRA KAFDAFNDNF EDQFKTSPNA NFAKFDGFEA HNFSSDFGNA1200
 1201 SFGTTGKEKQ NGQVDKKFQS KEPVKDKFAA DYSKPESFDA DLEEALKRSV LDN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    SHOWING SINGLE HITS. [ Hide Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..229] PSI-BLAST 25.69897 No description for 2qptA was found.
    2 View Details [230..689] PSI-BLAST 39.154902 Heavy meromyosin subfragment
    3 View Details [690..765] deduced N/A No confident structure predictions are available.
    4 View Details [766..819] deduced N/A No confident structure predictions are available.
    5 View Details [820..922] deduced N/A No confident structure predictions are available.
    6 View Details [923..1034] deduced N/A No confident structure predictions are available.
    7 View Details [1035..1253] MSA 3.237994 View MSA. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle