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Protein Overview: Eps-15-PB

General Information:
Name(s) found: Eps-15-PB / FBpp0072339 [FlyBase]
Description(s) found:
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  • gi|24762736|ref|NP_726482.1| Eps-15, isoform B [Drosophila melanogaster] [NCBI NR]
  • gi|21645078|gb|AAM70793.1| Eps-15, isoform B [Drosophila melanogaster] [NCBI NR]
  • The gene Epidermal growth factor receptor pathway substrate clone 15 is referred to in FlyBase by the symbol Dmel\Eps-15 (CG16932, FBgn0035060). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:20655837..20662788. It has the cytological map location 60E1. An electronic pipeline based on InterPro domains suggests that it has the molecular function</span>: calcium ion binding. There is experimental evidence that it is involved in the biological process</span>: synaptic vesicle endocytosis; vesicle-mediated transport; regulation of synaptic growth at neuromuscular junction. 15 alleles are reported. The phenotypes of these alleles are annotated with: bouton; larval neuromuscular junction. It has 3 annotated transcripts and 3 annotated polypeptides. [FlyBase]
  • >CG16932-PB translation from_gene[CG16932 Eps-15 FBgn0035060] seq_release:3 mol_weight=132112 cds_boundaries:(2R:19,812,254..19,818,543[-]) aa_length:1232 transcript_info:[CG16932-RB seq_release:3] gene_info:[gene symbol:Eps-15 FBgn0035060 gene_boundar [hmr_yeast5_DM3-1_pombe.fasta]
  • (Q8MMD2) CG16932-PB [DrosMelano7227.FASTAC.txt]
  • CG16932-PB, isoform B [Drosophila melanogaster]gi|24762736|ref|NP_726482.1| CG16932-PB [Drosophila melanogaster] [nrdb_11152004_Chlamydomonas]
  • type=protein; loc=2R:complement(20656204..20656883,20656942..20657584,20659248..20659313,20659372..20659560,20659621..20660064,20660121..20660318,20660735..20660824,20660885..20661206,20661265..20662028,20662100..20662336,20662431..20662496); ID=FBpp00723 [fly-100309-contam.fasta]
  • Eps-15 CG16932-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • CG16932-PB, isoform B [Drosophila melanogaster] [nr-271106-contam.fasta]
  • type=protein; loc=2R:complement(20656204..20656883,20656942..20657584,20659248..20659313,20659372..20659560,20659621..20660064,20660121..20660318,20660735..20660824,20660885..20661206,20661265..20662028,20662100..20662336,20662431..20662496); ID=FBpp0072339; name=Eps-15-PB; parent=FBgn0035060,FBtr0072434; dbxref=FlyBase:FBpp0072339,FlyBase_Annotation_IDs:CG16932-PB,GB_protein:AAM70793.1,REFSEQ:NP_726482,GB_protein:AAM70793; MD5=ac07fc515632433f8c0e68cf4de5cf2c; length=1232; release=r5.16; species=Dmel; [fly-contam-His-TEV-Tub4complex.fasta]
  • type=protein; loc=2R:complement(20656204..20656883,20656942..20657584,20659248..20659313,20659372..20659560,20659621..20660064,20660121..20660318,20660735..20660824,20660885..20661206,20661265..20662028,20662100..20662336,20662431..20662496); ID=FBpp0072339; name=Eps-15-PB; parent=FBgn0035060,FBtr0072434; dbxref=FlyBase:FBpp0072339,FlyBase_Annotation_IDs:CG16932-PB,GB_protein:AAM70793.1,REFSEQ:NP_726482,GB_protein:AAM70793; MD5=ac07fc515632433f8c0e68cf4de5cf2c; length=1232; release=r5.21; species=Dmel; [Other_drosophila_na_09-09-2009_reversed.fasta]
  • Epidermal growth factor receptor pathway substrate clone 15, isoform B OS=Drosophila melanogaster GN=Eps-15 PE=1 SV=1 [UniProt_drosophila_07-01-2011_reversed.fasta]
  • type=protein; loc=2R:complement(20656204..20656883,20656942..20657584,20659248..20659313,20659372..20659560,20659621..20660064,20660121..20660318,20660735..20660824,20660885..20661206,20661265..20662028,20662100..20662336,20662431..20662496); ID=FBpp0072339; name=Eps-15-PB; parent=FBgn0035060,FBtr0072434; dbxref=FlyBase:FBpp0072339,FlyBase_Annotation_IDs:CG16932-PB,GB_protein:AAM70793.1,REFSEQ:NP_726482,GB_protein:AAM70793,FlyMine:FBpp0072339,modMine:FBpp0072339; MD5=ac07fc515632433f8c0e68cf4de5cf2c; length=1232; release=r5.46; species=Dmel; [fly-062812-sfps-sandra-contam.fasta]
  • Epidermal growth factor receptor pathway substrate clone 15, isoform B OS=Drosophila melanogaster GN=Eps-15 PE=2 SV=1 [UniProt_D_Melanogaster_07132012_07-13-2012_reversed.fasta]
  • type=protein; loc=2R:complement(join(24774908..24774973,24774577..24774813,24773742..24774505,24773362..24773683,24773212..24773301,24772598..24772795,24772098..24772541,24771849..24772037,24771725..24771790,24769419..24770061,24768681..24769360)); ID=FBpp0072339; name=Eps-15-PB; parent=FBgn0035060,FBtr0072434; dbxref=FlyBase:FBpp0072339,FlyBase_Annotation_IDs:CG16932-PB,GB_protein:AAM70793.1,REFSEQ:NP_726482,GB_protein:AAM70793,FlyMine:FBpp0072339,modMine:FBpp0072339; MD5=ac07fc515632433f8c0e68cf4de5cf2c; length=1232; release=r6.02; species=Dmel; [fly-2014-05-contam.fasta]
  • type=protein; loc=2R:complement(join(24774908..24774973,24774577..24774813,24773742..24774505,24773362..24773683,24773212..24773301,24772598..24772795,24772098..24772541,24771849..24772037,24771725..24771790,24769419..24770061,24768681..24769360)); ID=FBpp0072339; name=Eps-15-PB; parent=FBgn0035060,FBtr0072434; dbxref=FlyBase:FBpp0072339,FlyBase_Annotation_IDs:CG16932-PB,GB_protein:AAM70793.1,REFSEQ:NP_726482,GB_protein:AAM70793,FlyMine:FBpp0072339,modMine:FBpp0072339; MD5=ac07fc515632433f8c0e68cf4de5cf2c; length=1232; release=r6.07; species=Dmel; [fly-08202015-contam.fasta]
  • Isoform of Q9W111, Epidermal growth factor receptor pathway substrate clone 15, isoform B OS=Drosophila melanogaster GN=Eps-15 PE=1 SV=1 [DROME.fasta.20160308]
  • FBpp0072339 type=protein; loc=2R:complement(join(24774908..24774973,24774577..24774813,24773742..24774505,24773362..24773683,24773212..24773301,24772598..24772795,24772098..24772541,24771849..24772037,24771725..24771790,24769419..24770061,24768681..24769360)); ID=FBpp0072339; name=Eps-15-PB; parent=FBgn0035060,FBtr0072434; dbxref=FlyBase:FBpp0072339,FlyBase_Annotation_IDs:CG16932-PB,GB_protein:AAM70793.1,REFSEQ:NP_726482,GB_protein:AAM70793,FlyMine:FBpp0072339,modMine:FBpp0072339; MD5=ac07fc515632433f8c0e68cf4de5cf2c; length=1232; release=r6.09; species=Dmel; [dmel-all-translation-r6.09.fasta]
  • [fly-122215-dmel-6-09-contam.fasta]
  • type=protein; loc=2R:complement(join(24774908..24774973,24774577..24774813,24773742..24774505,24773362..24773683,24773212..24773301,24772598..24772795,24772098..24772541,24771849..24772037,24771725..24771790,24769419..24770061,24768681..24769360)); ID=FBpp0072339; name=Eps-15-PB; parent=FBgn0035060,FBtr0072434; dbxref=FlyBase:FBpp0072339,FlyBase_Annotation_IDs:CG16932-PB,GB_protein:AAM70793.1,REFSEQ:NP_726482,GB_protein:AAM70793,UniProt/TrEMBL:Q8MMD2,FlyMine:FBpp0072339,modMine:FBpp0072339; MD5=ac07fc515632433f8c0e68cf4de5cf2c; length=1232; release=r6.14; species=Dmel; [fly-dmel-jan2017-sandracontam.fasta]
    • Organism: Drosophila melanogaster
    Length: 1232 amino acids

    Gene Ontology:
    Cellular Component: synaptic vesicle [IDA]
    Biological Process: vesicle-mediated transport [IMP]
    synaptic vesicle endocytosis [IMP][TAS]
    regulation of synaptic growth at neuromuscular junction [IMP]
    receptor-mediated endocytosis [NAS]
    neurotransmitter secretion [NAS]
    Molecular Function: calcium ion binding [IEA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNVDFARVCG KHIGVYEAYY KLIDPKGTGA IEAMTAAKFL KKSGLSDVVL SRIWDLSDPS  60
   61 GKGFLDKPGF FVALKLVSLS QAGQVASMAN IYLDIANPPK LGELPKTMPS RIQTVPVASG 120
  121 GVANGDWSIG VIDRLKYEQL FESLHPSNGM LPGNKVKGVL MDSKLPMSIL GTIWDLADQD 180
  181 KDGNLDMHEF VVAMHLVYQT LQKRTIPSVL PPELRKPGGA GPPPKPAMPP PPAGAAMPRA 240
  241 PSGEGFGDGG FVANFPKDIA PPAAIPPLPV AVPPMTRIPP VGAVSSQPLI QTDPLIPIGA 300
  301 PVMANADWVV TPADLKRFEE IFRQSDLDKD GLVSGLEVKD IFIKSGIPQR SLADIWALCD 360
  361 TNQSGKLTVE QFALAMWFVE RKQRGVDPPH VLNANMVPPS MRATVAGVDL QPQEVKPTYS 420
  421 NPELEMISKE IEELARERRV LETEIAQKEA DVRIKNGEVR SLQSELDTLT ATLKQLENQR 480
  481 GEAQKRLDDL QAQVTKIRDQ CHMQEVTINE QEGELNAKRS ELQKLKDEEA SLQKEYDSNN 540
  541 RELSKLTNHL QATQLQISSV RSMVTQLLET QRQMTDALLI CRAAMENQNA ELVSEYQLKI 600
  601 EPDFDEARKT LTKEVQLPKD DPFEENNSGA ANQATNGFGS DPFSGQPVNK PAISTGFDDS 660
  661 FNMSSGFDSG FDAFGQSGAG SAFGQTQRDP FGSDAFAANK SNAITPEPGK DDFGSDPFAA 720
  721 LHAPTGQGQV LSPNAQKSGP PPRPESPSPA LPPKKSKVPP PRPAPPRAAQ PTGGFGSGGG 780
  781 GGFADFDDFD NKLHHIPSAP SPSATALSPL PPTLPAPIPV VSGSSLLDSF TLFDDPGQIH 840
  841 KQAASTPNPT PITVPTVHTL LQTSLSTPAA PSPALASLST SGSGSVAGAG ADLPSSVTIT 900
  901 TAPSLNNQHL SRSNTPLQNQ RTADVKLETK AVVSVFDAFG EIGTRKAPTP SLITGPTDFK 960
  961 DDPFKDYRYE DPFSIKDPFA EEGEEELSEG KGADHKRNFA EDFSSGDEIG SAAKTLSNIV1020
 1021 NNNSIKPKAA TPLNNDLLQQ FDAFNLNSSP APSHHSGTSY HSNSKPSHDS QTALDAFADF1080
 1081 DDFAATLATT GGSGAATTAT TTGNTKLNNS FFDAFNDNFS VIQSSSVPTG VVRPNDQRAK1140
 1141 AFDAFNDNFE DQFKTSPNAN FAKFDGFEAH NFSSDFGNAS FGTTGKEKQN GQVDKKFQSK1200
 1201 EPVKDKFAAD YSKPESFDAD LEEALKRSVL DN

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..229] PSI-BLAST 37.69897 No description for 2qptA was found.
    2 View Details [230..600] PSI-BLAST 33.30103 Heavy meromyosin subfragment
    3 View Details [601..673] PSI-BLAST 13.69897 Tropomyosin
    4 View Details [674..834] deduced N/A No confident structure predictions are available.
    5 View Details [835..1119] deduced N/A No confident structure predictions are available.
    6 View Details [1120..1232] MSA 4.219997 View MSA. No confident structure predictions are available.


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle