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Protein Overview: SerT-PA, FBpp0309974

General Information:
Name(s) found: FBpp0309974 [FlyBase]
SerT-PA / FBpp0072269 [FlyBase]
Description(s) found:
Found 31 descriptions.
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  • type=protein; loc=2R:complement(20292975..20293220,20293280..20293480,20294048..20294342,20294456..20294908,20294965..20295175,20296486..20296762,20296910..20297095); ID=FBpp0309974; name=SerT-PB; parent=FBgn0010414,FBtr0343316; dbxref=FlyBase:FBpp0309974,FlyBase_Annotation_IDs:CG4545-PB; MD5=e3bd73ca2a2cbb520663a034cff11aa2; length=622; release=r5.56; species=Dmel; [FlyBase]
  • The gene Serotonin transporter is referred to in FlyBase by the symbol Dmel\SerT (CG4545, FBgn0010414). It is a protein_coding_gene from Drosophila melanogaster. Its sequence location is 2R:20292118..20298070. It has the cytological map location 60C8. There is experimental evidence that it has the molecular function</span>: serotonin transmembrane transporter activity; monoamine transmembrane transporter activity; cation channel activity. There is experimental evidence that it is involved in the biological process</span>: serotonin uptake; monoamine transport; serotonin transport; phagocytosis, engulfment. 4 alleles are reported. No phenotypic data is available. It has one annotated transcript and one annotated polypeptide. [FlyBase]
    • Organism: Drosophila melanogaster
    Length: 622 amino acids

    Gene Ontology:
    Cellular Component: integral to plasma membrane [IEA][NAS]
    plasma membrane [ISS]
    axon [IDA]
    axon terminus [IDA]
    Biological Process: serotonin uptake [IDA]
    phagocytosis, engulfment [IMP]
    serotonin transport [IDA]
    monoamine transport [IDA]
    Molecular Function: serotonin transmembrane transporter activity [IDA][NAS]
    neurotransmitter:sodium symporter activity [IEA]
    cation channel activity [IDA]
    monoamine transmembrane transporter activity [IDA]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDRSGSSDFA GAAATTGRSN PAPWSDDKES PNNEDDSNED DGDHTTPAKV TDPLAPKLAN  60
   61 NERILVVSVT ERTRETWGQK AEFLLAVIGF AVDLGNVWRF PYICYQNGGG AFLVPYCLFL 120
  121 IFGGLPLFYM ELALGQFHRC GCLSIWKRIC PALKGVGYAI CLIDIYMGMY YNTIIGWAVY 180
  181 YLFASFTSKL PWTSCDNPWN TENCMQVTSE NFTELATSPA KEFFERKVLE SYKGNGLDFM 240
  241 GPVKPTLALC VFGVFVLVYF SLWKGVRSAG KVVWVTALAP YVVLIILLVR GVSLPGADEG 300
  301 IKYYLTPEWH KLKNSKVWID AASQIFFSLG PGFGTLLALS SYNKFNNNCY RDALITSSIN 360
  361 CLTSFLAGFV IFSVLGYMAY VQKTSIDKVG LEGPGLVFIV YPEAIATMSG SVFWSIIFFL 420
  421 MLITLGLDST FGGLEAMITA LCDEYPRVIG RRRELFVLLL LAFIFLCALP TMTYGGVVLV 480
  481 NFLNVYGPGL AILFVVFVEA AGVFWFYGVD RFSSDVEQML GSKPGLFWRI CWTYISPVFL 540
  541 LTIFIFSIMG YKEMLGEEYY YPDWSYQVGW AVTCSSVLCI PMYIIYKFFF ASKGGCRQRL 600
  601 QESFQPEDNC GSVVPGQQGT SV

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    No mass spectrometry results found for this protein.

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


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    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..622] PSI-BLAST 54.69897 Crystal structure of LEUTAA, a bacterial homolog of Na+/Cl--dependent neurotransmitter transporters


    Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
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